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    Zbtb43 zinc finger and BTB domain containing 43 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb43provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 43provided by RGD
    Primary source
    RGD:1310287
    See related
    EnsemblRapid:ENSRNOG00000017017 AllianceGenome:RGD:1310287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp297b
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase III general transcription initiation factor binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Orthologous to human ZBTB43 (zinc finger and BTB domain containing 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 84.7), Liver (RPKM 78.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb43 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (37142210..37161524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16744535..16763854, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (12489774..12509372, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene uncharacterized LOC102550017 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 43
    Names
    zinc finger protein 297B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012094.1 → NP_001012094.1  zinc finger and BTB domain-containing protein 43

      See identical proteins and their annotated locations for NP_001012094.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087042
      UniProtKB/TrEMBL
      A0A8I5ZT40, A0A8I6AJA1, Q5PQT4
      Related
      ENSRNOP00000022814.4, ENSRNOT00000022814.4
      Conserved Domains (3) summary
      sd00017
      Location:412 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:44 → 164
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:450 → 473
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      37142210..37161524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233973.4 → XP_006234035.1  zinc finger and BTB domain-containing protein 43 isoform X1

      See identical proteins and their annotated locations for XP_006234035.1

      UniProtKB/TrEMBL
      A0A8I5ZT40, A0A8I6AFN4, A6JUA9
      Related
      ENSRNOP00000086987.1, ENSRNOT00000108027.2
      Conserved Domains (3) summary
      sd00017
      Location:376 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8 → 128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414 → 437
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006233974.4 → XP_006234036.1  zinc finger and BTB domain-containing protein 43 isoform X1

      See identical proteins and their annotated locations for XP_006234036.1

      UniProtKB/TrEMBL
      A0A8I5ZT40, A0A8I6AFN4, A6JUA9
      Related
      ENSRNOP00000096140.1, ENSRNOT00000117382.2
      Conserved Domains (3) summary
      sd00017
      Location:376 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18227
      Location:8 → 128
      BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
      pfam13465
      Location:414 → 437
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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