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    Polr2e RNA polymerase II, I and III subunit E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690966, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2eprovided by RGD
    Official Full Name
    RNA polymerase II, I and III subunit Eprovided by RGD
    Primary source
    RGD:1589817
    See related
    EnsemblRapid:ENSRNOG00000013545 AllianceGenome:RGD:1589817
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase II; and transcription elongation by RNA polymerase I. Predicted to be located in nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and nuclear DNA-directed RNA polymerase complex. Orthologous to human POLR2E (RNA polymerase II, I and III subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 343.5), Kidney (RPKM 301.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polr2e in Genome Data Viewer
    Location:
    7q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10317332..10321280)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9666695..9670638)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12532785..12536797)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4 Neighboring gene uncharacterized LOC134479812 Neighboring gene Rho GTPase activating protein 45 Neighboring gene ATP binding cassette subfamily A member 7 Neighboring gene uncharacterized LOC134479813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Conservation between the RNA polymerase I, II, and III transcription initiation machineries. Vannini A, et al. Mol Cell, 2012 Feb 24. PMID 22365827
    2. Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. Shilatifard A, et al. J Biol Chem, 1997 Aug 29. PMID 9268387
    3. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article
    4. Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Dumay-Odelot H, et al. Cell Cycle, 2010 Sep 15. PMID 20890107, Free PMC Article
    5. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA. Gene, 2012 Feb 10. PMID 21893173, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerases I, II, and III subunit RPABC1
    Names
    DNA-directed RNA polymerase II subunit E
    RNA polymerase II subunit E
    RNA polymerases I, II, and III subunit ABC1
    RPB5 homolog
    polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
    polymerase (RNA) II subunit E
    NP_001103084.1
    XP_006241071.1
    XP_006241072.1
    XP_006241073.1
    XP_038935858.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109614.1 → NP_001103084.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1

      See identical proteins and their annotated locations for NP_001103084.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474029
      UniProtKB/Swiss-Prot
      B0BNE2
      UniProtKB/TrEMBL
      A0A1W2Q690, A6K8S4
      Conserved Domains (1) summary
      PLN03111
      Location:1 → 209
      PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10317332..10321280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079930.2 → XP_038935858.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X3

      UniProtKB/Swiss-Prot
      B0BNE2
      UniProtKB/TrEMBL
      A0A1W2Q690, A6K8S4
      Related
      ENSRNOP00000076239.1, ENSRNOT00000093413.3
      Conserved Domains (1) summary
      PLN03111
      Location:1 → 209
      PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional

    2. XM_006241009.5 → XP_006241071.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1

      See identical proteins and their annotated locations for XP_006241071.1

      UniProtKB/TrEMBL
      A0A8L2Q9B5, A6K8S6
      Conserved Domains (3) summary
      PLN03111
      Location:1 → 190
      PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional
      pfam01191
      Location:138 → 190
      RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
      pfam03871
      Location:4 → 92
      RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain

    3. XM_006241011.3 → XP_006241073.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X4

      See identical proteins and their annotated locations for XP_006241073.1

      UniProtKB/TrEMBL
      A0A1W2Q690, A6K8S9
      Related
      ENSRNOP00000076166.3, ENSRNOT00000093599.3
      Conserved Domains (3) summary
      PLN03111
      Location:15 → 201
      PLN03111; DNA-directed RNA polymerase II subunit family protein; Provisional
      pfam01191
      Location:130 → 201
      RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
      pfam03871
      Location:11 → 84
      RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain

    4. XM_006241010.3 → XP_006241072.1  DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X2

      Conserved Domains (2) summary
      pfam01191
      Location:130 → 182
      RNA_pol_Rpb5_C; RNA polymerase Rpb5, C-terminal domain
      pfam03871
      Location:11 → 84
      RNA_pol_Rpb5_N; RNA polymerase Rpb5, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNE2.1 GenPept UniProtKB/Swiss-Prot:B0BNE2

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