atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: atp6ap2provided by Xenbase
Official Full Name: ATPase, H+ transporting, lysosomal accessory protein 2provided by Xenbase
Primary source: Xenbase:XB-GENE-964301
See related: Ensembl:ENSXETG00000015523 AllianceGenome:Xenbase:XB-GENE-964301
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to act upstream of or within apical protein localization and intrahepatic bile duct development. Predicted to be located in bounding membrane of organelle; dendritic spine membrane; and endoplasmic reticulum membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (56947110..56962003, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	2	NC_030678.1 (70202245..70217141, complement)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

prorenin receptor(PRR)& V-ATPase were required to mediate Wnt signaling during antero-posterior patterning of early central nervous system development; results reveal an unsuspected role for PRR, V-ATPase activity & acidification during Wnt signaling
Title: Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrahepatic bile duct development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendritic spine membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: renin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.