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    Eral1 Era-like 12S mitochondrial rRNA chaperone 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eral1provided by RGD
    Official Full Name
    Era-like 12S mitochondrial rRNA chaperone 1provided by RGD
    Primary source
    RGD:1304714
    See related
    EnsemblRapid:ENSRNOG00000010673 AllianceGenome:RGD:1304714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable rRNA binding activity and ribosomal small subunit binding activity. Predicted to be involved in ribosomal small subunit assembly. Predicted to be located in cytosol and mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in Perrault syndrome 6. Orthologous to human ERAL1 (Era like 12S mitochondrial rRNA chaperone 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 139.3), Muscle (RPKM 117.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eral1 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63459774..63466829, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62961725..62968747, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65272849..65291070)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 451a Neighboring gene microRNA 144 Neighboring gene uncharacterized LOC134480829 Neighboring gene family with sequence similarity 222, member B Neighboring gene Tnf receptor associated factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Potentiation of excitatory transmission in substantia gelatinosa neurons of rat spinal cord by inhibition of estrogen receptor alpha. Zhong YQ, et al. Mol Pain, 2010 Dec 11. PMID 21143988, Free PMC Article
    2. Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. Dennerlein S, et al. Biochem J, 2010 Sep 15. PMID 20604745, Free PMC Article
    3. A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome. Chatzispyrou IA, et al. Hum Mol Genet, 2017 Jul 1. PMID 28449065, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC109051

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTPase Era, mitochondrial
    Names
    ERA-like protein 1
    Era (G-protein)-like 1
    Era-like 1
    GTP-binding protein era homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013229.2 → NP_001013247.1  GTPase Era, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001013247.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y1U7
      Conserved Domains (3) summary
      cd04163
      Location:111 → 320
      Era; E. coli Ras-like protein (Era) is a multifunctional GTPase
      COG1159
      Location:108 → 431
      Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]
      pfam07650
      Location:357 → 425
      KH_2; KH domain

    2. NM_001399476.1 → NP_001386405.1  GTPase Era, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D4A9P4, D4ADH1, Q5EBA0
      UniProtKB/TrEMBL
      A0A8I5Y1U7
      Related
      ENSRNOP00000078025.1, ENSRNOT00000098969.2
      Conserved Domains (1) summary
      COG1159
      Location:108 → 437
      Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]

    3. NM_001399477.1 → NP_001386406.1  GTPase Era, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y1U7, A0A8L2Q6T2
      Related
      ENSRNOP00000107836.1, ENSRNOT00000134296.1
      Conserved Domains (1) summary
      COG1159
      Location:108 → 410
      Era; GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63459774..63466829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EBA0.2 GenPept UniProtKB/Swiss-Prot:Q5EBA0

    Gene LinkOut

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