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    Trak2 trafficking kinesin protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trak2provided by RGD
    Official Full Name
    trafficking kinesin protein 2provided by RGD
    Primary source
    RGD:620915
    See related
    EnsemblRapid:ENSRNOG00000010881 AllianceGenome:RGD:620915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GRIF-1; Als2cr3
    Summary
    Enables several functions, including GABA receptor binding activity; TPR domain binding activity; and kinesin binding activity. Involved in several processes, including dendrite morphogenesis; dendritic transport of mitochondrion; and negative regulation of axonogenesis. Located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Orthologous to human TRAK2 (trafficking kinesin protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 565.1), Spleen (RPKM 396.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trak2 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67842680..67909786, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60348531..60414036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65698706..65763351, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene caspase 8 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene uncharacterized LOC120094796 Neighboring gene transfer RNA valine (anticodon AAC) 15 Neighboring gene STE20 related adaptor beta Neighboring gene uncharacterized LOC120094795 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GRIF1 binds Hrs and is a new regulator of endosomal trafficking. Kirk E, et al. J Cell Sci, 2006 Nov 15. PMID 17062640
    2. Delineation of the TRAK binding regions of the kinesin-1 motor proteins. Randall TS, et al. FEBS Lett, 2013 Nov 29. PMID 24161670, Free PMC Article
    3. Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. Loss O, et al. J Neurosci Res, 2015 Jul. PMID 25653102
    4. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. MacAskill AF, et al. Mol Cell Neurosci, 2009 Mar. PMID 19103291
    5. Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. Beck M, et al. J Biol Chem, 2002 Aug 16. PMID 12034717

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93214

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GABA receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables TPR domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinesin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendritic transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrion distribution IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trafficking kinesin-binding protein 2
    Names
    GABA-A receptor interacting factor-1
    O-GlcNAc transferase-interacting protein of 98 kDa
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog
    trafficking protein, kinesin binding 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133560.2 → NP_598244.2  trafficking kinesin-binding protein 2

      See identical proteins and their annotated locations for NP_598244.2

      Status: VALIDATED

      Source sequence(s)
      AJ288898, BC088393
      UniProtKB/Swiss-Prot
      Q8R2H6, Q8R2H7, Q8R4G3
      UniProtKB/TrEMBL
      A6IP85, A6IP87
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 353
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:426 → 565
      Milton; Kinesin associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67842680..67909786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266622.1 → XP_063122692.1  trafficking kinesin-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R2H6, Q8R2H7, Q8R4G3
      UniProtKB/TrEMBL
      A6IP85, A6IP87

    2. XM_063266621.1 → XP_063122691.1  trafficking kinesin-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R2H6, Q8R2H7, Q8R4G3
      UniProtKB/TrEMBL
      A6IP85, A6IP87

    3. XM_063266623.1 → XP_063122693.1  trafficking kinesin-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A6IP86

    4. XM_063266620.1 → XP_063122690.1  trafficking kinesin-binding protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q8R2H6, Q8R2H7, Q8R4G3
      UniProtKB/TrEMBL
      A6IP85, A6IP87

    5. XM_017596256.3 → XP_017451745.1  trafficking kinesin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K434, A6IP85
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:445 → 584
      Milton; Kinesin associated protein

    6. XM_008767072.3 → XP_008765294.1  trafficking kinesin-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008765294.1

      UniProtKB/TrEMBL
      A0A0G2K434, A6IP85
      Related
      ENSRNOP00000015035.5, ENSRNOT00000015034.9
      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:445 → 584
      Milton; Kinesin associated protein

    7. XM_039082996.2 → XP_038938924.1  trafficking kinesin-binding protein 2 isoform X3

      Conserved Domains (2) summary
      pfam04849
      Location:50 → 372
      HAP1_N; HAP1 N-terminal conserved region
      pfam12448
      Location:433 → 584
      Milton; Kinesin associated protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2H7.2 GenPept UniProtKB/Swiss-Prot:Q8R2H7

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