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    Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25255, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dyrk1aprovided by RGD
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 1Aprovided by RGD
    Primary source
    RGD:2528
    See related
    EnsemblRapid:ENSRNOG00000001662 AllianceGenome:RGD:2528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dyrk; PSK47
    Summary
    Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including protein phosphorylation; regulation of RNA splicing; and regulation of cardiac muscle tissue growth. Located in nuclear speck. Used to study congestive heart failure and dilated cardiomyopathy. Biomarker of hyperhomocysteinemia; myocardial infarction; and renovascular hypertension. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 179.0), Muscle (RPKM 155.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dyrk1a in Genome Data Viewer
    Location:
    11q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (47360824..47479033)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33890706..34009420)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34858339..34958733)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene VPS26 endosomal protein sorting factor C Neighboring gene uncharacterized LOC120095638 Neighboring gene uncharacterized LOC102550239 Neighboring gene uncharacterized LOC134481061 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tau protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle hypertrophy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell growth involved in cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neurofilament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1A
    Names
    Dual Specificity Yak1-related kinase
    MNBH
    RP86
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
    protein kinase minibrain homolog
    NP_036923.1
    XP_038943954.1
    XP_038943955.1
    XP_038943956.1
    XP_038943959.1
    XP_038943960.1
    XP_063126374.1
    XP_063126375.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012791.3NP_036923.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A

      See identical proteins and their annotated locations for NP_036923.1

      Status: REVIEWED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q63470
      UniProtKB/TrEMBL
      A0A8I5ZY45, A6KPV9
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      47360824..47479033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088026.2XP_038943954.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      UniProtKB/Swiss-Prot
      Q63470
      UniProtKB/TrEMBL
      A0A8I5ZY45, A6KPV9
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. XM_039088031.2XP_038943959.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZY45, A0A8I6GL29
      Related
      ENSRNOP00000096172.1, ENSRNOT00000114109.2
      Conserved Domains (1) summary
      cd14226
      Location:139475
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. XM_063270304.1XP_063126374.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      UniProtKB/Swiss-Prot
      Q63470
      UniProtKB/TrEMBL
      A0A8I5ZY45, A6KPV9
    4. XM_039088027.2XP_038943955.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      UniProtKB/Swiss-Prot
      Q63470
      UniProtKB/TrEMBL
      A0A8I5ZY45, A6KPV9
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    5. XM_039088028.2XP_038943956.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

      UniProtKB/Swiss-Prot
      Q63470
      UniProtKB/TrEMBL
      A0A8I5ZY45, A6KPV9
      Conserved Domains (1) summary
      cd14226
      Location:148484
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    6. XM_063270305.1XP_063126375.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZY45, A0A8I6GL29
    7. XM_039088032.2XP_038943960.1  dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZY45
      Related
      ENSRNOP00000042446.6, ENSRNOT00000050342.7
      Conserved Domains (1) summary
      cd14226
      Location:119455
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1