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    Tmem184a transmembrane protein 184A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304325, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem184aprovided by RGD
    Official Full Name
    transmembrane protein 184Aprovided by RGD
    Primary source
    RGD:1306702
    See related
    EnsemblRapid:ENSRNOG00000001275 AllianceGenome:RGD:1306702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306702
    Summary
    Predicted to enable heparin binding activity and transmembrane transporter activity. Predicted to act upstream of or within germ-line sex determination; regulation of protein localization; and regulation of secretion. Located in plasma membrane. Orthologous to human TMEM184A (transmembrane protein 184A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 229.2), Lung (RPKM 24.1) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem184a in Genome Data Viewer
    Location:
    12q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19931360..19945913)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (14817508..14833109)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16906863..16924143)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC134481158 Neighboring gene proteasome assembly chaperone 3 Neighboring gene uncharacterized LOC102546414 Neighboring gene MAF bZIP transcription factor K Neighboring gene integrator complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin. Pugh RJ, et al. J Biol Chem, 2016 Mar 4. PMID 26769966, Free PMC Article
    2. Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues. Best D, et al. Dev Dyn, 2009 Jan. PMID 19097053
    3. Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice. Best D, et al. Development, 2008 Apr. PMID 18321981, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM184A is a heparin receptor in vascular cells.
      Title: Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within germ-line sex determination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 184A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025413.1 → NP_001020584.1  transmembrane protein 184A

      See identical proteins and their annotated locations for NP_001020584.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098056
      UniProtKB/Swiss-Prot
      Q4QQS1, Q5XHY9
      UniProtKB/TrEMBL
      A0A0G2K4I7
      Conserved Domains (1) summary
      pfam03619
      Location:61 → 330
      Solute_trans_a; Organic solute transporter Ostalpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19931360..19945913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248939.5 → XP_006249001.1  transmembrane protein 184A isoform X2

      See identical proteins and their annotated locations for XP_006249001.1

      UniProtKB/Swiss-Prot
      Q4QQS1, Q5XHY9
      UniProtKB/TrEMBL
      A0A0G2K4I7
      Conserved Domains (1) summary
      pfam03619
      Location:61 → 330
      Solute_trans_a; Organic solute transporter Ostalpha

    2. XM_006248938.5 → XP_006249000.1  transmembrane protein 184A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4I7, A0A8L2UH93
      Related
      ENSRNOP00000001718.5, ENSRNOT00000001718.7
      Conserved Domains (1) summary
      pfam03619
      Location:82 → 352
      Solute_trans_a; Organic solute transporter Ostalpha

    3. XM_063271273.1 → XP_063127343.1  transmembrane protein 184A isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4I7

    4. XM_039089390.2 → XP_038945318.2  transmembrane protein 184A isoform X4

      UniProtKB/TrEMBL
      A0A0G2K4I7

    5. XM_063271274.1 → XP_063127344.1  transmembrane protein 184A isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQS1.1 GenPept UniProtKB/Swiss-Prot:Q4QQS1

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