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    Zmynd19 zinc finger, MYND domain containing 19 [ Mus musculus (house mouse) ]

    Gene ID: 67187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zmynd19provided by MGI
    Official Full Name
    zinc finger, MYND domain containing 19provided by MGI
    Primary source
    MGI:MGI:1914437
    See related
    Ensembl:ENSMUSG00000026974 AllianceGenome:MGI:1914437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mizip; 2700064H14Rik
    Summary
    Predicted to enable metal ion binding activity. Located in cytoplasm; membrane; and synapse. Is expressed in central nervous system; male reproductive system; and urinary system. Orthologous to human ZMYND19 (zinc finger MYND-type containing 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.2), CNS E11.5 (RPKM 8.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zmynd19 in Genome Data Viewer
    Location:
    2 A3; 2 16.86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24839789..24850882)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24949777..24960870)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5898 Neighboring gene STARR-positive B cell enhancer ABC_E1001 Neighboring gene diphthamine biosynethesis 7 Neighboring gene mitochondrial ribosomal protein L41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating hormone receptor 1 in the adult rodent brain. Francke F, et al. Brain Res Mol Brain Res, 2005 Sep 13. PMID 15950311
    2. MIZIP, a highly conserved, vertebrate specific melanin-concentrating hormone receptor 1 interacting zinc-finger protein. Bächner D, et al. FEBS Lett, 2002 Aug 28. PMID 12208518
    3. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. Saita S, et al. J Biol Chem, 2014 Sep 12. PMID 25077969, Free PMC Article
    4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
    5. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger MYND domain-containing protein 19
    Names
    MCH-R1-interacting zinc finger protein
    melanin concentrating hormone receptor interacting zinc finger protein
    melanin-concentrating hormone receptor 1-interacting zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026021.4 → NP_080297.1  zinc finger MYND domain-containing protein 19 isoform 1

      See identical proteins and their annotated locations for NP_080297.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes encodes the longer isoform (1).
      Source sequence(s)
      AK012484, AL732585, AL935039, CJ154709
      Consensus CDS
      CCDS15742.1
      UniProtKB/Swiss-Prot
      Q8K1T3, Q9CQG3
      Related
      ENSMUSP00000028350.4, ENSMUST00000028350.9
      Conserved Domains (2) summary
      pfam01753
      Location:174 → 212
      zf-MYND; MYND finger
      cl00083
      Location:66 → 105
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

    2. NM_147179.1 → NP_671708.1  zinc finger MYND domain-containing protein 19 isoform 2

      See identical proteins and their annotated locations for NP_671708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' most exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL732525, AL732585, AL935039
      Consensus CDS
      CCDS79745.1
      UniProtKB/Swiss-Prot
      Q9CQG3
      Related
      ENSMUSP00000141788.2, ENSMUST00000148042.3
      Conserved Domains (2) summary
      pfam01753
      Location:135 → 173
      zf-MYND; MYND finger
      cl00083
      Location:27 → 66
      HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24839789..24850882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQG3.1 GenPept UniProtKB/Swiss-Prot:Q9CQG3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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