Corin corin, serine peptidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Corinprovided by RGD
Official Full Name: corin, serine peptidaseprovided by RGD
Primary source: RGD:727887
See related: EnsemblRapid:ENSRNOG00000002302 AllianceGenome:RGD:727887
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase activity. Involved in regulation of blood pressure and regulation of renal sodium excretion. Located in cytoplasmic vesicle and plasma membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertension; and pre-eclampsia. Orthologous to human CORIN (corin, serine peptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 408.1), Testes (RPKM 23.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (36034613..36264671)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (35680601..35910703)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (38247379..38474931)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced serum corin level in humans and rodents is positively correlated with high salt diet-induced systolic blood pressure and 24-hour urinary Na+ and albumin excretion, which suggests that corin is involved in the salt-water balance in response to HS intake.
Title: Short-Term High-Salt Diet Increases Corin Level to Regulate the Salt-Water Balance in Humans and Rodents.
Corin contributes to the progression of diabetic ED and the underlying mechanism is associated with the down-regulation of ANP /NO/cGMP signal pathway.
Title: The Involvement of Corin in the Progression of Diabetic Erectile Dysfunction in a Rat Model by Down-Regulating ANP /NO/cGMP Signal Pathway.
Corin mRNA and protein are downregulated in diabetic cardiomyopathy (DCM). Corin plays an important role in cardioprotection by activating pro-atrial natriuretic peptide pathway in DCM.
Title: Corin is down-regulated and exerts cardioprotective action via activating pro-atrial natriuretic peptide pathway in diabetic cardiomyopathy.
corin might be involved in the salt retention seen in glomerular diseases.
Title: Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases.
N-linked oligosaccharides play an important role in corin activation
Title: Role of glycosylation in corin zymogen activation.
Downregulation of atrial corin mRNA expression may be a novel mechanism for the blunted ANP release in heart failure.
Title: Rat corin gene: molecular cloning and reduced expression in experimental heart failure.
corin gene is upregulated in hypertrophic cardiomyocytes and failing myocardium and may contribute to elevation of ANP in the setting of cardiac hypertrophy and heart failure.
Title: Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium.

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General gene information

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Markers

D14Rat118 (e-PCR), detects polymorphism
- UniSTS:226618

D14Wox4 (e-PCR)
- UniSTS:239224

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of renal sodium excretion	IEA Inferred from Electronic Annotation more info
involved_in regulation of renal sodium excretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of renal sodium excretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by atrial natriuretic peptide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: atrial natriuretic peptide-converting enzyme

Names: pro-ANP-converting enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182473.2 → NP_872279.2 atrial natriuretic peptide-converting enzyme

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

D3ZN44, F1LS60, Q80YN4

UniProtKB/TrEMBL

A6JD74, J3QTE2

Related

ENSRNOP00000061602.2, ENSRNOT00000064128.5

Conserved Domains (6) summary

cd07445
Location:200 → 329

CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd07888
Location:521 → 641

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd00112
Location:372 → 406

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:867 → 1098

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:646 → 680

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl02509
Location:779 → 859

SRCR_2; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

36034613..36264671

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008770139.4 → XP_008768361.1 atrial natriuretic peptide-converting enzyme isoform X1

UniProtKB/TrEMBL

A0A8I6AD87, A0A8I6AIB1

Related

ENSRNOP00000104752.1, ENSRNOT00000133364.1

Conserved Domains (7) summary

cd07445
Location:134 → 263

CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd07888
Location:455 → 575

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

smart00020
Location:800 → 1029

Tryp_SPc; Trypsin-like serine protease

cd00112
Location:306 → 340

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:801 → 1032

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:580 → 614

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl02509
Location:713 → 793

SRCR_2; Scavenger receptor cysteine-rich domain
XM_063272920.1 → XP_063128990.1 atrial natriuretic peptide-converting enzyme isoform X3
XM_039091707.2 → XP_038947635.1 atrial natriuretic peptide-converting enzyme isoform X2

Conserved Domains (5) summary

cd07888
Location:210 → 330

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd00112
Location:61 → 95

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:556 → 787

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:335 → 369

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl02509
Location:468 → 548

SRCR_2; Scavenger receptor cysteine-rich domain
XM_063272921.1 → XP_063128991.1 atrial natriuretic peptide-converting enzyme isoform X5
XM_039091709.2 → XP_038947637.1 atrial natriuretic peptide-converting enzyme isoform X4

Conserved Domains (5) summary

cd07888
Location:192 → 312

CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease

cd00112
Location:43 → 77

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

cd00190
Location:538 → 769

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00057
Location:317 → 351

Ldl_recept_a; Low-density lipoprotein receptor domain class A

cl02509
Location:450 → 530

SRCR_2; Scavenger receptor cysteine-rich domain