Rps18 ribosomal protein S18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps18provided by RGD
Official Full Name: ribosomal protein S18provided by RGD
Primary source: RGD:3595
See related: EnsemblRapid:ENSRNOG00000000471 AllianceGenome:RGD:3595
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ke3
Summary: Enables protein kinase binding activity. Predicted to be involved in ganglioside biosynthetic process; protein glycosylation; and translation. Part of cytosolic small ribosomal subunit. Orthologous to human RPS18 (ribosomal protein S18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 7720.7), Thymus (RPKM 5730.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4933741..4937423)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4931427..4935538)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5441875..5445553)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study demonstrates that gene expression levels of reference genes commonly used in obesity-related studies, such as ACTB or RPS18, are altered by changes in acute or chronic energy status.
Title: Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity.
Data show that S18-2 can immortalize rat embryonic fibroblasts and induces them to express stem cell traits.
Title: MRPS18-2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ganglioside biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of rough endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small ribosomal subunit protein uS13

Names: 40S ribosomal protein S18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.