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    Itgb1bp1 integrin subunit beta 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298914, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgb1bp1provided by RGD
    Official Full Name
    integrin subunit beta 1 binding protein 1provided by RGD
    Primary source
    RGD:1307810
    See related
    EnsemblRapid:ENSRNOG00000059402 AllianceGenome:RGD:1307810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP-dissociation inhibitor activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including regulation of cell migration; regulation of cell-substrate adhesion; and regulation of signal transduction. Predicted to be located in several cellular components, including centriolar satellite; nuclear body; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Orthologous to human ITGB1BP1 (integrin subunit beta 1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 133.2), Muscle (RPKM 125.0) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itgb1bp1 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46549994..46564735, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40820693..40836074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43348927..43363633, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479349 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA21 Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene isoamyl acetate hydrolyzing esterase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel diameter maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion involved in substrate-bound cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    integrin beta-1-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106719.2NP_001100189.1  integrin beta-1-binding protein 1

      See identical proteins and their annotated locations for NP_001100189.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169104
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
      Related
      ENSRNOP00000071708.3, ENSRNOT00000092192.3
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    2. NM_001434252.1NP_001421181.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    3. NM_001434253.1NP_001421182.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    4. NM_001434254.1NP_001421183.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    5. NM_001434255.1NP_001421184.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    6. NM_001434256.1NP_001421185.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
    7. NM_001434257.1NP_001421186.1  integrin beta-1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      46549994..46564735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239980.5XP_006240042.1  integrin beta-1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    2. XM_039111953.2XP_038967881.1  integrin beta-1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    3. XM_039111951.2XP_038967879.1  integrin beta-1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    4. XM_006239979.5XP_006240041.1  integrin beta-1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    5. XM_006239981.5XP_006240043.1  integrin beta-1-binding protein 1 isoform X1

      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain
    6. XM_063261656.1XP_063117726.1  integrin beta-1-binding protein 1 isoform X1

    7. XM_039111952.2XP_038967880.1  integrin beta-1-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K157, A0A8I6GLU4, A6HAV6, B5DFL3
      Conserved Domains (1) summary
      cl17171
      Location:1199
      PH-like; Pleckstrin homology-like domain