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Spermatogenic failure 76

Summary

Spermatogenic failure-76 (SPGF76) is characterized by male infertility due to oligoasthenoteratozoospermia. Multiple morphologic abnormalities of the flagella (MMAF) have been observed, including short, absent, and irregular caliber flagella. Ultrastructural anomalies include disordered outer dense fibers and abnormal 9+2 microtubular structures (Cong et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150). [from OMIM]

Genes See tests for all associated and related genes

  • Also known as: L15, NY-REN-41, RAMA3, SPGF76, CCDC34
    Summary: coiled-coil domain containing 34

Clinical features

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Imported from Human Phenotype Ontology (HPO)

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