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Old-aged sensorineural hearing impairment

MedGen UID:
10911
•Concept ID:
C0033074
•
Pathologic Function
Synonyms: Age-related hearing impairment; Presbycusis
SNOMED CT: Age-related hearing loss (49526009); Presbycusis (49526009); Senile deafness (49526009); Presbyacusia (49526009)
 
HPO: HP:0040113
Monarch Initiative: MONDO:0043765

Definition

Bilateral hearing loss caused by progressive degeneration of cochlear structures and central auditory pathways, typically associated with the aging process. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOld-aged sensorineural hearing impairment

Conditions with this feature

Autosomal dominant nonsyndromic hearing loss 31
MedGen UID:
325209
•Concept ID:
C1837617
•
Disease or Syndrome
An autosomal dominant nonsyndromic deafness that has material basis in variation in the chromosome region 6p21.3.
See: Condition Record
Autosomal dominant nonsyndromic hearing loss 31

Professional guidelines

PubMed

Clinical Practice Guideline: Age-Related Hearing Loss.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Keenan TA, Kim AH, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170 Suppl 2:S1-S54. doi: 10.1002/ohn.750. PMID: 38687845
Clinical Practice Guideline: Age-Related Hearing Loss Executive Summary.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Kim AH, Keenan TA, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170(5):1209-1227. doi: 10.1002/ohn.749. PMID: 38682789
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044

Recent clinical studies

Etiology

The Effects of Age-Related Hearing Loss on the Brain and Cognitive Function.
Slade K, Plack CJ, Nuttall HE
Trends Neurosci 2020 Oct;43(10):810-821. Epub 2020 Aug 19 doi: 10.1016/j.tins.2020.07.005. PMID: 32826080
Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes.
Jafari Z, Kolb BE, Mohajerani MH
Ageing Res Rev 2019 Dec;56:100963. Epub 2019 Sep 23 doi: 10.1016/j.arr.2019.100963. PMID: 31557539
Age-related Hearing Loss and Dementia.
Chern A, Golub JS
Alzheimer Dis Assoc Disord 2019 Jul-Sep;33(3):285-290. doi: 10.1097/WAD.0000000000000325. PMID: 31335455Free PMC Article
Age-Related Hearing Loss.
Bowl MR, Dawson SJ
Cold Spring Harb Perspect Med 2019 Aug 1;9(8) doi: 10.1101/cshperspect.a033217. PMID: 30291149Free PMC Article
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA
JAMA Otolaryngol Head Neck Surg 2018 Feb 1;144(2):115-126. doi: 10.1001/jamaoto.2017.2513. PMID: 29222544Free PMC Article

Diagnosis

Clinical Practice Guideline: Age-Related Hearing Loss.
Tsai Do BS, Bush ML, Weinreich HM, Schwartz SR, Anne S, Adunka OF, Bender K, Bold KM, Brenner MJ, Hashmi AZ, Keenan TA, Kim AH, Moore DJ, Nieman CL, Palmer CV, Ross EJ, Steenerson KK, Zhan KY, Reyes J, Dhepyasuwan N
Otolaryngol Head Neck Surg 2024 May;170 Suppl 2:S1-S54. doi: 10.1002/ohn.750. PMID: 38687845
Age-Related Hearing Loss.
Lin FR
N Engl J Med 2024 Apr 25;390(16):1505-1512. doi: 10.1056/NEJMcp2306778. PMID: 38657246
Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline.
Rutherford BR, Brewster K, Golub JS, Kim AH, Roose SP
Am J Psychiatry 2018 Mar 1;175(3):215-224. Epub 2017 Dec 5 doi: 10.1176/appi.ajp.2017.17040423. PMID: 29202654Free PMC Article
Presbycusis-peripheral and central.
Parham K, Kost KM
Ear Nose Throat J 2017 Dec;96(12):462-463. PMID: 29236268
Presbycusis.
Gates GA, Mills JH
Lancet 2005 Sep 24-30;366(9491):1111-20. doi: 10.1016/S0140-6736(05)67423-5. PMID: 16182900

Therapy

Geriatric sudden deafness.
Zhang BY, Young YH
Am J Otolaryngol 2021 Jul-Aug;42(4):102985. Epub 2021 Feb 16 doi: 10.1016/j.amjoto.2021.102985. PMID: 33610920
Age-related Hearing Loss and Dementia.
Chern A, Golub JS
Alzheimer Dis Assoc Disord 2019 Jul-Sep;33(3):285-290. doi: 10.1097/WAD.0000000000000325. PMID: 31335455Free PMC Article
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA
JAMA Otolaryngol Head Neck Surg 2018 Feb 1;144(2):115-126. doi: 10.1001/jamaoto.2017.2513. PMID: 29222544Free PMC Article
Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline.
Rutherford BR, Brewster K, Golub JS, Kim AH, Roose SP
Am J Psychiatry 2018 Mar 1;175(3):215-224. Epub 2017 Dec 5 doi: 10.1176/appi.ajp.2017.17040423. PMID: 29202654Free PMC Article
Presbyacusis.
Jennings CR, Jones NS
J Laryngol Otol 2001 Mar;115(3):171-8. doi: 10.1258/0022215011906984. PMID: 11244520

Prognosis

Electrocochleographic frequency-following responses as a potential marker of age-related cochlear neural degeneration.
Temboury-Gutierrez M, Märcher-Rørsted J, Bille M, Yde J, Encina-Llamas G, Hjortkjær J, Dau T
Hear Res 2024 May;446:109005. Epub 2024 Apr 4 doi: 10.1016/j.heares.2024.109005. PMID: 38598943
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Boucher S, Tai FWJ, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C
Proc Natl Acad Sci U S A 2020 Dec 8;117(49):31278-31289. Epub 2020 Nov 23 doi: 10.1073/pnas.2010782117. PMID: 33229591Free PMC Article
Cortical cognitive potentials in elderly persons.
Stenklev NC, Laukli E
J Am Acad Audiol 2004 Jun;15(6):401-13. doi: 10.3766/jaaa.15.6.2. PMID: 15341222
Sudden hearing loss in the elderly.
Zikk D, Himelfarb MZ, Shanon E
Clin Otolaryngol Allied Sci 1985 Aug;10(4):191-4. doi: 10.1111/j.1365-2273.1985.tb00239.x. PMID: 4053419
Hearing sensitivity in rural Michigan.
Townsend TH, Bess FH, Fishbeck WA
Am Ind Hyg Assoc J 1975 Jan;36(1):63-8. doi: 10.1080/0002889758507209. PMID: 1111269

Clinical prediction guides

Electrocochleographic frequency-following responses as a potential marker of age-related cochlear neural degeneration.
Temboury-Gutierrez M, Märcher-Rørsted J, Bille M, Yde J, Encina-Llamas G, Hjortkjær J, Dau T
Hear Res 2024 May;446:109005. Epub 2024 Apr 4 doi: 10.1016/j.heares.2024.109005. PMID: 38598943
Age-related hearing loss associated with differences in the neural correlates of feature binding in visual working memory.
Loughrey DG, Jordan C, Ibanez A, Parra MA, Lawlor BA, Reilly RB
Neurobiol Aging 2023 Dec;132:233-245. Epub 2023 Sep 28 doi: 10.1016/j.neurobiolaging.2023.09.016. PMID: 37866083
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Boucher S, Tai FWJ, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C
Proc Natl Acad Sci U S A 2020 Dec 8;117(49):31278-31289. Epub 2020 Nov 23 doi: 10.1073/pnas.2010782117. PMID: 33229591Free PMC Article
Hearing Loss in Adults: Differential Diagnosis and Treatment.
Michels TC, Duffy MT, Rogers DJ
Am Fam Physician 2019 Jul 15;100(2):98-108. PMID: 31305044
Non-implantable Artificial Hearing Technology.
Lu L, Zhang X, Gao X
Adv Exp Med Biol 2019;1130:145-163. doi: 10.1007/978-981-13-6123-4_9. PMID: 30915706

Recent systematic reviews

Hearing Loss in Exfoliation Syndrome: Systematic Review and Meta-Analysis.
Shih MC, Gordis TM, Lambert PR, Nguyen SA, Meyer TA
Laryngoscope 2023 May;133(5):1025-1035. Epub 2022 Sep 10 doi: 10.1002/lary.30384. PMID: 36087028
Association of Age-Related Hearing Loss With Cognitive Function, Cognitive Impairment, and Dementia: A Systematic Review and Meta-analysis.
Loughrey DG, Kelly ME, Kelley GA, Brennan S, Lawlor BA
JAMA Otolaryngol Head Neck Surg 2018 Feb 1;144(2):115-126. doi: 10.1001/jamaoto.2017.2513. PMID: 29222544Free PMC Article
Bilateral versus unilateral hearing aids for bilateral hearing impairment in adults.
Schilder AG, Chong LY, Ftouh S, Burton MJ
Cochrane Database Syst Rev 2017 Dec 19;12(12):CD012665. doi: 10.1002/14651858.CD012665.pub2. PMID: 29256573Free PMC Article
Auditory deprivation and health in the elderly.
Cherko M, Hickson L, Bhutta M
Maturitas 2016 Jun;88:52-7. Epub 2016 Mar 14 doi: 10.1016/j.maturitas.2016.03.008. PMID: 27105698
Determinants of hearing-aid adoption and use among the elderly: a systematic review.
Ng JH, Loke AY
Int J Audiol 2015 May;54(5):291-300. Epub 2015 Feb 2 doi: 10.3109/14992027.2014.966922. PMID: 25640403

Supplemental Content

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    Clinical resources

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