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Partial hyposmia

MedGen UID:
869339
•Concept ID:
C4023765
•
Finding
HPO: HP:0010635

Definition

Reduced ability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPartial hyposmia

Professional guidelines

PubMed

Screening performances of an 8-item UPSIT Italian version in the diagnosis of Parkinson's disease.
Landolfi A, Picillo M, Pellecchia MT, Troisi J, Amboni M, Barone P, Erro R
Neurol Sci 2023 Mar;44(3):889-895. Epub 2022 Nov 19 doi: 10.1007/s10072-022-06457-2. PMID: 36401656Free PMC Article
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Congenital hypogonadotropic hypogonadism in females: clinical spectrum, evaluation and genetics.
Bry-Gauillard H, Trabado S, Bouligand J, Sarfati J, Francou B, Salenave S, Chanson P, Brailly-Tabard S, Guiochon-Mantel A, Young J
Ann Endocrinol (Paris) 2010 May;71(3):158-62. Epub 2010 Apr 3 doi: 10.1016/j.ando.2010.02.024. PMID: 20363464

Recent clinical studies

Etiology

Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort study.
Amer MA, Elsherif HS, Abdel-Hamid AS, Elzayat S
Am J Otolaryngol 2020 Nov-Dec;41(6):102725. Epub 2020 Sep 14 doi: 10.1016/j.amjoto.2020.102725. PMID: 32979666Free PMC Article
The close relationship between sudden loss of smell and COVID-19.
Joffily L, Ungierowicz A, David AG, Melo B, Brito CLT, Mello L, Santos PSCD, Pezato R
Braz J Otorhinolaryngol 2020 Sep-Oct;86(5):632-638. Epub 2020 May 25 doi: 10.1016/j.bjorl.2020.05.002. PMID: 32561220Free PMC Article
Epidemiology of smell and taste dysfunction.
Doty RL
Handb Clin Neurol 2019;164:3-13. doi: 10.1016/B978-0-444-63855-7.00001-0. PMID: 31604555
Reversal of idiopathic hypogonadotropic hypogonadism.
Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF Jr, Pitteloud N
N Engl J Med 2007 Aug 30;357(9):863-73. doi: 10.1056/NEJMoa066494. PMID: 17761590
Posttraumatic olfactory loss.
Costanzo RM, Miwa T
Adv Otorhinolaryngol 2006;63:99-107. doi: 10.1159/000093753. PMID: 16733335

Diagnosis

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism.
Aung Y, Kokotsis V, Yin KN, Banerjee K, Butler G, Dattani MT, Dimitri P, Dunkel L, Hughes C, McGuigan M, Korbonits M, Paltoglou G, Sakka S, Shah P, Storr HL, Willemsen RH, Howard SR
Front Endocrinol (Lausanne) 2023;14:1226839. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1226839. PMID: 37701896Free PMC Article
COVID-19 reinfection after pregnancy.
Gobin L, Vallée A, Zucman D, Carbonnel M, Laperrelle J, Brugière O, Martin A, Ayoubi JM, Farfour E
Infect Dis Now 2022 Mar;52(2):101-103. Epub 2022 Jan 20 doi: 10.1016/j.idnow.2022.01.002. PMID: 35065269Free PMC Article
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Posttraumatic olfactory loss.
Costanzo RM, Miwa T
Adv Otorhinolaryngol 2006;63:99-107. doi: 10.1159/000093753. PMID: 16733335
Chemical senses.
Bartoshuk LM, Beauchamp GK
Annu Rev Psychol 1994;45:419-49. doi: 10.1146/annurev.ps.45.020194.002223. PMID: 8135507

Therapy

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Improvement in Olfaction in Patients With CRSwNP and Severe Asthma Taking Anti-IgE and Anti-IL-5 Biologics: A Real-Life Study.
Barroso B, Valverde-Monge M, Alobid I, Olaguibel JM, Rial MJ, Quirce S, Arismendi E, Barranco P, Betancor D, Bobolea I, Cárdaba B, Cruz Carmona MJ, Curto E, Domínguez-Ortega J, González-Barcala FJ, Martínez-Rivera C, Mahíllo-Fernández I, Muñoz X, Picado C, Plaza V, Rodrigo Muñoz JM, Soto-Retes L, Valero A, Del Pozo V, Mullol J, Sastre J
J Investig Allergol Clin Immunol 2023 Feb 17;33(1):37-44. Epub 2022 Apr 13 doi: 10.18176/jiaci.0812. PMID: 35416154
Spectrum of Neurological Manifestations in Covid-19: A Review.
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Management of chronic sinusitis in cystic fibrosis.
Davidson TM, Murphy C, Mitchell M, Smith C, Light M
Laryngoscope 1995 Apr;105(4 Pt 1):354-8. doi: 10.1288/00005537-199504000-00002. PMID: 7715376

Prognosis

COVID-19 reinfection after pregnancy.
Gobin L, Vallée A, Zucman D, Carbonnel M, Laperrelle J, Brugière O, Martin A, Ayoubi JM, Farfour E
Infect Dis Now 2022 Mar;52(2):101-103. Epub 2022 Jan 20 doi: 10.1016/j.idnow.2022.01.002. PMID: 35065269Free PMC Article
The close relationship between sudden loss of smell and COVID-19.
Joffily L, Ungierowicz A, David AG, Melo B, Brito CLT, Mello L, Santos PSCD, Pezato R
Braz J Otorhinolaryngol 2020 Sep-Oct;86(5):632-638. Epub 2020 May 25 doi: 10.1016/j.bjorl.2020.05.002. PMID: 32561220Free PMC Article
Chronic rhinosinusitis.
Ocampo CJ, Grammer LC
J Allergy Clin Immunol Pract 2013 May-Jun;1(3):205-11; quiz 212-3. Epub 2013 Feb 6 doi: 10.1016/j.jaip.2012.12.001. PMID: 24565477
Reversal of idiopathic hypogonadotropic hypogonadism.
Raivio T, Falardeau J, Dwyer A, Quinton R, Hayes FJ, Hughes VA, Cole LW, Pearce SH, Lee H, Boepple P, Crowley WF Jr, Pitteloud N
N Engl J Med 2007 Aug 30;357(9):863-73. doi: 10.1056/NEJMoa066494. PMID: 17761590
Posttraumatic olfactory loss.
Costanzo RM, Miwa T
Adv Otorhinolaryngol 2006;63:99-107. doi: 10.1159/000093753. PMID: 16733335

Clinical prediction guides

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism.
Aung Y, Kokotsis V, Yin KN, Banerjee K, Butler G, Dattani MT, Dimitri P, Dunkel L, Hughes C, McGuigan M, Korbonits M, Paltoglou G, Sakka S, Shah P, Storr HL, Willemsen RH, Howard SR
Front Endocrinol (Lausanne) 2023;14:1226839. Epub 2023 Aug 28 doi: 10.3389/fendo.2023.1226839. PMID: 37701896Free PMC Article
COVID-19 reinfection after pregnancy.
Gobin L, Vallée A, Zucman D, Carbonnel M, Laperrelle J, Brugière O, Martin A, Ayoubi JM, Farfour E
Infect Dis Now 2022 Mar;52(2):101-103. Epub 2022 Jan 20 doi: 10.1016/j.idnow.2022.01.002. PMID: 35065269Free PMC Article
Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection.
Trachootham D, Thongyen S, Lam-Ubol A, Chotechuang N, Pongpirul W, Prasithsirikul W
Int J Infect Dis 2021 May;106:329-337. Epub 2021 Apr 2 doi: 10.1016/j.ijid.2021.03.083. PMID: 33819604Free PMC Article
Spectrum of Neurological Manifestations in Covid-19: A Review.
Garg RK
Neurol India 2020 May-Jun;68(3):560-572. doi: 10.4103/0028-3886.289000. PMID: 32643664
Epidemiology of smell and taste dysfunction.
Doty RL
Handb Clin Neurol 2019;164:3-13. doi: 10.1016/B978-0-444-63855-7.00001-0. PMID: 31604555

Recent systematic reviews

Anosmia or Ageusia Following COVID-19 Vaccination: A Systematic Review.
Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.
Keshavarz P, Haseli S, Yazdanpanah F, Bagheri F, Raygani N, Karimi-Galougahi M
Acad Radiol 2021 Nov;28(11):1530-1540. Epub 2021 Aug 30 doi: 10.1016/j.acra.2021.08.010. PMID: 34548231Free PMC Article
Objective Sensory Testing Methods Reveal a Higher Prevalence of Olfactory Loss in COVID-19-Positive Patients Compared to Subjective Methods: A Systematic Review and Meta-Analysis.
Hannum ME, Ramirez VA, Lipson SJ, Herriman RD, Toskala AK, Lin C, Joseph PV, Reed DR
Chem Senses 2020 Dec 5;45(9):865-874. doi: 10.1093/chemse/bjaa064. PMID: 33245136Free PMC Article

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