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NCBI Reference Sequence: NM_031806.1
FASTA Graphics
LOCUS NM_031806 2236 bp mRNA linear ROD 09-OCT-2020 DEFINITION Rattus norvegicus G protein-coupled receptor 6 (Gpr6), mRNA. ACCESSION NM_031806 VERSION NM_031806.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2236) AUTHORS Breivogel CS, McPartland JM and Parekh B. TITLE Investigation of non-CB1, non-CB2 WIN55212-2-sensitive G-protein-coupled receptors in the brains of mammals, birds, and amphibians JOURNAL J Recept Signal Transduct Res 38 (4), 316-326 (2018) PUBMED 30376752 REMARK GeneRIF: Pharmacological evidence of this receptor was found in the brains of mammals and pigeon, but not frog or newt. Bioinfomatics results implicate GPR6 as a possible candidate for the additional WIN55212-2-sensitive receptor. REFERENCE 2 (bases 1 to 2236) AUTHORS Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O and Tenner AJ. TITLE C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity JOURNAL J Biol Chem 288 (1), 654-665 (2013) PUBMED 23150673 REMARK GeneRIF: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity REFERENCE 3 (bases 1 to 2236) AUTHORS Padmanabhan S, Myers AG and Prasad BM. TITLE Constitutively active GPR6 is located in the intracellular compartments JOURNAL FEBS Lett 583 (1), 107-112 (2009) PUBMED 19059244 REMARK GeneRIF: The localization of GPR6 in HEK293 cells and striatal neurons was assessed. REFERENCE 4 (bases 1 to 2236) AUTHORS Ignatov A, Lintzel J, Kreienkamp HJ and Schaller HC. TITLE Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway JOURNAL Biochem Biophys Res Commun 311 (2), 329-336 (2003) PUBMED 14592418 REFERENCE 5 (bases 1 to 2236) AUTHORS Chenn A, Levin ME and McConnell SK. TITLE Temporally and spatially regulated expression of a candidate G-protein-coupled receptor during cerebral cortical development JOURNAL J Neurobiol 46 (3), 167-177 (2001) PUBMED 11169503 REMARK Erratum:[J Neurobiol 2001 Jun 5;47(3):244] REFERENCE 6 (bases 1 to 2236) AUTHORS Song ZH, Young WS 3rd, Brownstein MJ and Bonner TI. TITLE Molecular cloning of a novel candidate G protein-coupled receptor from rat brain JOURNAL FEBS Lett 351 (3), 375-379 (1994) PUBMED 8082799 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF064706.1. [WARNING] On Nov 26, 2020 this sequence was replaced by NM_031806.2. Summary: may mediate later differentiation events within the superficial cortical layers during cerebral cortical development [RGD, Feb 2006]. ##Evidence-Data-START## Transcript exon combination :: AF064706.1, CB611745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689595 [ECO:0000348] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..2236 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="20" /map="20q12" gene 1..2236 /gene="Gpr6" /note="G protein-coupled receptor 6" /db_xref="GeneID:83683" /db_xref="RGD:70939" exon 1..130 /gene="Gpr6" /inference="alignment:Splign:2.0.8" misc_feature 120..122 /gene="Gpr6" /note="upstream in-frame stop codon" exon 131..2236 /gene="Gpr6" /inference="alignment:Splign:2.0.8" CDS 150..1241 /gene="Gpr6" /note="putative G protein-coupled receptor (CNL3); sphingosine 1-phosphate receptor GPR6" /codon_start=1 /product="G-protein coupled receptor 6" /protein_id="NP_113994.1" /db_xref="GeneID:83683" /db_xref="RGD:70939" /translation="MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAA LGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTP ALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSL LAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRASCS VVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATR KGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRN QEIQRALWLLFCGCFQSKVPFRSRSPSEV" misc_feature 153..155 /gene="Gpr6" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P51651.1); glycosylation site" misc_feature 174..176 /gene="Gpr6" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P51651.1); glycosylation site" misc_feature 303..305 /gene="Gpr6" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P51651.1); glycosylation site" misc_feature 375..434 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 471..542 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 579..644 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 708..767 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 843..899 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 984..1064 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 1080..1145 /gene="Gpr6" /note="propagated from UniProtKB/Swiss-Prot (P51651.1); transmembrane region" misc_feature 1218..1220 /gene="Gpr6" /note="Phosphoserine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P51651.1); phosphorylation site" misc_feature 1224..1226 /gene="Gpr6" /note="Phosphoserine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P51651.1); phosphorylation site" misc_feature 1230..1232 /gene="Gpr6" /note="Phosphoserine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (P51651.1); phosphorylation site" ORIGIN 1 ctcagggaca ggagaccagt actttcctct tcgacgcggg gcagcctcct gcaggcagct 61 gctcggaccg cgtagggcac acagccgcgg agcgcatgac cagagactcc cgggagccct 121 gactcctcag ggagcagcat ctggcggcga tgaacgctag cgccgccgcg ctcaacgagt 181 cccaggtggt ggcagtagcg gccgagggag cggcagctgc ggctacagca gcagggacac 241 cggacaccag cgaatgggga cctccggcag catccgcggc gctgggaggc ggcggaggac 301 ctaacgggtc actggagctg tcttcgcagc tgcccgcagg accctcagga cttctgcttt 361 cggcagtgaa tccctgggat gtgctgctgt gcgtgtcggg gactgtgatc gcaggcgaaa 421 atgcgctggt ggtggcgctc atcgcatcca ctcccgcgct gcgcacgccc atgtttgtgc 481 tcgtgggtag tctggccact gctgacctgc tggcgggctg tggcctcatc ctacacttcg 541 tgttccagta cgtggtgccc tcggagactg tgagcctgct catggtgggc ttcctggtgg 601 cgtccttcgc cgcctcagtc agcagcctgc tcgctatcac agtggaccgt tacctgtccc 661 tttacaacgc gctcacctac tactcgcgcc ggaccctgtt gggcgtgcac ctcttgctag 721 cagccacctg gacagtgtcc ctcgggttgg ggttgctgcc cgttctaggc tggaactgct 781 tggctgaccg cgcgtcctgc agcgtggtgc gccccctgac acgcagccat gtggcgttgc 841 tctccacttc cttctttgtg gtctttggca tcatgctaca cttgtacgtg cgcatctgcc 901 aggtggtctg gcgccacgcc caccagatcg ctttgcaaca gcactgccta gcaccaccac 961 acttagcagc caccagaaag ggtgtgggaa ctttggccgt ggtgctaggc acttttgggg 1021 ccagctggct gcccttcgcc atctattgtg tggtgggtag ccaagaggac ccggccatct 1081 acacctatgc caccctgctg cctgccacct ataactccat gatcaatccc atcatctatg 1141 ccttccgcaa ccaggagatc cagcgtgcct tgtggctcct gttctgtggc tgtttccaat 1201 ccaaagtgcc cttccgctcc aggtccccca gtgaggtctg aagggctcct ccgtgtctcc 1261 tcacccacat cacaaatcca acatgccggc ctttggtgag cttctaggtg cctgctgatg 1321 aactcttgag gactcagtgg ttcggcgcga gtctgactgc cccgcaaagg gactggatgt 1381 gaacgcaaca aactgactca gacaaagagg cttgttggca ttttacatat acagtgtata 1441 cacgtgtaca tatatataca aatatttgta tcttctggag gtgttcaggg cctggagctt 1501 cccgttctgt gaaaaaaact aacaaaatgt ggttgtatac tcaatcgtac atcacatttg 1561 tcaagtgaag acattccaat actgcttaat aatagcactt tatttttagc tgctgaaatg 1621 ccaagacagt gttgccatcc ccaagagcag gagaaaggga gtcagagatg tatttttgtt 1681 gtatgtgata gaatattttg ctgcacatgc atcagtaaac tacaacatat tttgtacaca 1741 aataaacaca ttataaaagt atgatcttgg gtatgtgata aattgtggca ttgtttggaa 1801 tctgaattgt gagtgtgttt attttaaaag tctactgcac atctatctat catctgtccc 1861 agggagagcc acatgaaata ccagatctaa accatgggat gaggcagtaa cattcatgag 1921 tcatggagga agtaacattc acacgtggca tccccagaac acgagaagga aggctgttac 1981 tggtgcaagt taatgtgctc tcttggtggc cgggttggga agacatgttt cagaggtcaa 2041 aacaattcaa gtcacatagg cacaggtgta aactctgaag ccacaactta ccagcataac 2101 tttacaaaca tgccaagatt tctcaacatg gcttattcag actgttgcta cccaggtctg 2161 gtagccaggt gcagagccca ataaaaccaa taaaattctc ctaaagcagg attcccagat 2221 cttcatgggg taactg //
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