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Rattus norvegicus G protein-coupled receptor 6 (Gpr6), mRNA

NCBI Reference Sequence: NM_031806.1

FASTA Graphics 

LOCUS       NM_031806               2236 bp    mRNA    linear   ROD 09-OCT-2020
DEFINITION  Rattus norvegicus G protein-coupled receptor 6 (Gpr6), mRNA.
ACCESSION   NM_031806
VERSION     NM_031806.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2236)
  AUTHORS   Breivogel CS, McPartland JM and Parekh B.
  TITLE     Investigation of non-CB1, non-CB2 WIN55212-2-sensitive
            G-protein-coupled receptors in the brains of mammals, birds, and
            amphibians
  JOURNAL   J Recept Signal Transduct Res 38 (4), 316-326 (2018)
   PUBMED   30376752
  REMARK    GeneRIF: Pharmacological evidence of this receptor was found in the
            brains of mammals and pigeon, but not frog or newt. Bioinfomatics
            results implicate GPR6 as a possible candidate for the additional
            WIN55212-2-sensitive receptor.
REFERENCE   2  (bases 1 to 2236)
  AUTHORS   Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O and Tenner
            AJ.
  TITLE     C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer
            disease mouse models, are essential for the C1q-mediated protection
            against amyloid-beta neurotoxicity
  JOURNAL   J Biol Chem 288 (1), 654-665 (2013)
   PUBMED   23150673
  REMARK    GeneRIF: C1q-induced LRP1B and GPR6 proteins expressed early in
            Alzheimer disease mouse models, are essential for the C1q-mediated
            protection against amyloid-beta neurotoxicity
REFERENCE   3  (bases 1 to 2236)
  AUTHORS   Padmanabhan S, Myers AG and Prasad BM.
  TITLE     Constitutively active GPR6 is located in the intracellular
            compartments
  JOURNAL   FEBS Lett 583 (1), 107-112 (2009)
   PUBMED   19059244
  REMARK    GeneRIF: The localization of GPR6 in HEK293 cells and striatal
            neurons was assessed.
REFERENCE   4  (bases 1 to 2236)
  AUTHORS   Ignatov A, Lintzel J, Kreienkamp HJ and Schaller HC.
  TITLE     Sphingosine-1-phosphate is a high-affinity ligand for the G
            protein-coupled receptor GPR6 from mouse and induces intracellular
            Ca2+ release by activating the sphingosine-kinase pathway
  JOURNAL   Biochem Biophys Res Commun 311 (2), 329-336 (2003)
   PUBMED   14592418
REFERENCE   5  (bases 1 to 2236)
  AUTHORS   Chenn A, Levin ME and McConnell SK.
  TITLE     Temporally and spatially regulated expression of a candidate
            G-protein-coupled receptor during cerebral cortical development
  JOURNAL   J Neurobiol 46 (3), 167-177 (2001)
   PUBMED   11169503
  REMARK    Erratum:[J Neurobiol 2001 Jun 5;47(3):244]
REFERENCE   6  (bases 1 to 2236)
  AUTHORS   Song ZH, Young WS 3rd, Brownstein MJ and Bonner TI.
  TITLE     Molecular cloning of a novel candidate G protein-coupled receptor
            from rat brain
  JOURNAL   FEBS Lett 351 (3), 375-379 (1994)
   PUBMED   8082799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF064706.1.
            
            [WARNING] On Nov 26, 2020 this sequence was replaced by
            NM_031806.2.
            
            Summary: may mediate later differentiation events within the
            superficial cortical layers during cerebral cortical development
            [RGD, Feb 2006].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF064706.1, CB611745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00052297, SAMEA2689595
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2236
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..2236
                     /gene="Gpr6"
                     /note="G protein-coupled receptor 6"
                     /db_xref="GeneID:83683"
                     /db_xref="RGD:70939"
     exon            1..130
                     /gene="Gpr6"
                     /inference="alignment:Splign:2.0.8"
     misc_feature    120..122
                     /gene="Gpr6"
                     /note="upstream in-frame stop codon"
     exon            131..2236
                     /gene="Gpr6"
                     /inference="alignment:Splign:2.0.8"
     CDS             150..1241
                     /gene="Gpr6"
                     /note="putative G protein-coupled receptor (CNL3);
                     sphingosine 1-phosphate receptor GPR6"
                     /codon_start=1
                     /product="G-protein coupled receptor 6"
                     /protein_id="NP_113994.1"
                     /db_xref="GeneID:83683"
                     /db_xref="RGD:70939"
                     /translation="MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAA
                     LGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTP
                     ALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSL
                     LAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRASCS
                     VVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATR
                     KGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRN
                     QEIQRALWLLFCGCFQSKVPFRSRSPSEV"
     misc_feature    153..155
                     /gene="Gpr6"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51651.1); glycosylation site"
     misc_feature    174..176
                     /gene="Gpr6"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51651.1); glycosylation site"
     misc_feature    303..305
                     /gene="Gpr6"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51651.1); glycosylation site"
     misc_feature    375..434
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    471..542
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    579..644
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    708..767
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    843..899
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    984..1064
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    1080..1145
                     /gene="Gpr6"
                     /note="propagated from UniProtKB/Swiss-Prot (P51651.1);
                     transmembrane region"
     misc_feature    1218..1220
                     /gene="Gpr6"
                     /note="Phosphoserine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (P51651.1); phosphorylation
                     site"
     misc_feature    1224..1226
                     /gene="Gpr6"
                     /note="Phosphoserine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (P51651.1); phosphorylation
                     site"
     misc_feature    1230..1232
                     /gene="Gpr6"
                     /note="Phosphoserine. /evidence=ECO:0000255; propagated
                     from UniProtKB/Swiss-Prot (P51651.1); phosphorylation
                     site"
ORIGIN      
        1 ctcagggaca ggagaccagt actttcctct tcgacgcggg gcagcctcct gcaggcagct
       61 gctcggaccg cgtagggcac acagccgcgg agcgcatgac cagagactcc cgggagccct
      121 gactcctcag ggagcagcat ctggcggcga tgaacgctag cgccgccgcg ctcaacgagt
      181 cccaggtggt ggcagtagcg gccgagggag cggcagctgc ggctacagca gcagggacac
      241 cggacaccag cgaatgggga cctccggcag catccgcggc gctgggaggc ggcggaggac
      301 ctaacgggtc actggagctg tcttcgcagc tgcccgcagg accctcagga cttctgcttt
      361 cggcagtgaa tccctgggat gtgctgctgt gcgtgtcggg gactgtgatc gcaggcgaaa
      421 atgcgctggt ggtggcgctc atcgcatcca ctcccgcgct gcgcacgccc atgtttgtgc
      481 tcgtgggtag tctggccact gctgacctgc tggcgggctg tggcctcatc ctacacttcg
      541 tgttccagta cgtggtgccc tcggagactg tgagcctgct catggtgggc ttcctggtgg
      601 cgtccttcgc cgcctcagtc agcagcctgc tcgctatcac agtggaccgt tacctgtccc
      661 tttacaacgc gctcacctac tactcgcgcc ggaccctgtt gggcgtgcac ctcttgctag
      721 cagccacctg gacagtgtcc ctcgggttgg ggttgctgcc cgttctaggc tggaactgct
      781 tggctgaccg cgcgtcctgc agcgtggtgc gccccctgac acgcagccat gtggcgttgc
      841 tctccacttc cttctttgtg gtctttggca tcatgctaca cttgtacgtg cgcatctgcc
      901 aggtggtctg gcgccacgcc caccagatcg ctttgcaaca gcactgccta gcaccaccac
      961 acttagcagc caccagaaag ggtgtgggaa ctttggccgt ggtgctaggc acttttgggg
     1021 ccagctggct gcccttcgcc atctattgtg tggtgggtag ccaagaggac ccggccatct
     1081 acacctatgc caccctgctg cctgccacct ataactccat gatcaatccc atcatctatg
     1141 ccttccgcaa ccaggagatc cagcgtgcct tgtggctcct gttctgtggc tgtttccaat
     1201 ccaaagtgcc cttccgctcc aggtccccca gtgaggtctg aagggctcct ccgtgtctcc
     1261 tcacccacat cacaaatcca acatgccggc ctttggtgag cttctaggtg cctgctgatg
     1321 aactcttgag gactcagtgg ttcggcgcga gtctgactgc cccgcaaagg gactggatgt
     1381 gaacgcaaca aactgactca gacaaagagg cttgttggca ttttacatat acagtgtata
     1441 cacgtgtaca tatatataca aatatttgta tcttctggag gtgttcaggg cctggagctt
     1501 cccgttctgt gaaaaaaact aacaaaatgt ggttgtatac tcaatcgtac atcacatttg
     1561 tcaagtgaag acattccaat actgcttaat aatagcactt tatttttagc tgctgaaatg
     1621 ccaagacagt gttgccatcc ccaagagcag gagaaaggga gtcagagatg tatttttgtt
     1681 gtatgtgata gaatattttg ctgcacatgc atcagtaaac tacaacatat tttgtacaca
     1741 aataaacaca ttataaaagt atgatcttgg gtatgtgata aattgtggca ttgtttggaa
     1801 tctgaattgt gagtgtgttt attttaaaag tctactgcac atctatctat catctgtccc
     1861 agggagagcc acatgaaata ccagatctaa accatgggat gaggcagtaa cattcatgag
     1921 tcatggagga agtaacattc acacgtggca tccccagaac acgagaagga aggctgttac
     1981 tggtgcaagt taatgtgctc tcttggtggc cgggttggga agacatgttt cagaggtcaa
     2041 aacaattcaa gtcacatagg cacaggtgta aactctgaag ccacaactta ccagcataac
     2101 tttacaaaca tgccaagatt tctcaacatg gcttattcag actgttgcta cccaggtctg
     2161 gtagccaggt gcagagccca ataaaaccaa taaaattctc ctaaagcagg attcccagat
     2221 cttcatgggg taactg
//
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