U.S. flag

An official website of the United States government

Rattus norvegicus RAS protein-specific guanine nucleotide-releasing factor 2 (Rasgrf2), mRNA

NCBI Reference Sequence: NM_053721.1

FASTA Graphics 

LOCUS       NM_053721               3573 bp    mRNA    linear   ROD 01-FEB-2021
DEFINITION  Rattus norvegicus RAS protein-specific guanine nucleotide-releasing
            factor 2 (Rasgrf2), mRNA.
ACCESSION   NM_053721
VERSION     NM_053721.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Wu RF, Liao C, Hatoum H, Fu G, Ochoa CD and Terada LS.
  TITLE     RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to
            Ras
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (1), 98-107 (2017)
   PUBMED   27856453
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Jin SX and Feig LA.
  TITLE     Long-term potentiation in the CA1 hippocampus induced by NR2A
            subunit-containing NMDA glutamate receptors is mediated by
            Ras-GRF2/Erk map kinase signaling
  JOURNAL   PLoS One 5 (7), e11732 (2010)
   PUBMED   20661302
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Zhang GC, Hoffmann J, Parelkar NK, Liu XY, Mao LM, Fibuch EE and
            Wang JQ.
  TITLE     Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein
            expression in the rat striatum in vivo
  JOURNAL   Neurosci Lett 427 (2), 117-121 (2007)
   PUBMED   17931779
  REMARK    GeneRIF: data identify the Ras activator, Ras-GRF1, although not
            Ras-GRF2, as a susceptible target to cocaine stimulation in
            striatal neurons
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Tian X, Gotoh T, Tsuji K, Lo EH, Huang S and Feig LA.
  TITLE     Developmentally regulated role for Ras-GRFs in coupling NMDA
            glutamate receptors to Ras, Erk and CREB
  JOURNAL   EMBO J 23 (7), 1567-1575 (2004)
   PUBMED   15029245
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F,
            Munoz MT, Egea G, Lafarga M and Crespo P.
  TITLE     Activation of H-Ras in the endoplasmic reticulum by the RasGRF
            family guanine nucleotide exchange factors
  JOURNAL   Mol Cell Biol 24 (4), 1516-1530 (2004)
   PUBMED   14749369
  REMARK    GeneRIF: RasGRF family exchange factors, both endogenous and
            ectopically expressed, are present in the endoplasmic reticulum but
            not in the Golgi complex
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Laes JF, Quan X, Ravoet M, Stieber D, Van Vooren P, Van Reeth T,
            Szpirer J and Szpirer C.
  TITLE     Analysis of candidate genes included in the mammary cancer
            susceptibility 1 (Mcs1) region
  JOURNAL   Mamm Genome 12 (3), 199-206 (2001)
   PUBMED   11252168
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE and Lowy DR.
  TITLE     Ras-specific exchange factor GRF: oligomerization through its Dbl
            homology domain and calcium-dependent activation of Raf
  JOURNAL   Mol Cell Biol 19 (7), 4611-4622 (1999)
   PUBMED   10373510
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   Fan WT, Koch CA, de Hoog CL, Fam NP and Moran MF.
  TITLE     The exchange factor Ras-GRF2 activates Ras-dependent and
            Rac-dependent mitogen-activated protein kinase pathways
  JOURNAL   Curr Biol 8 (16), 935-938 (1998)
   PUBMED   9707409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ276774.1.
            
            [WARNING] On Mar 10, 2021 this sequence was replaced by
            NM_053721.2.
            
            Summary: human homolog is involved in stimulating the conversion of
            the GDP-bound form of Ras into the active form [RGD, Feb 2006].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ276774.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3573
                     /gene="Rasgrf2"
                     /note="RAS protein-specific guanine nucleotide-releasing
                     factor 2"
                     /db_xref="GeneID:114513"
                     /db_xref="RGD:69413"
     CDS             1..3573
                     /gene="Rasgrf2"
                     /note="ras-GRF2; guanine nucleotide-releasing factor 2;
                     ras guanine nucleotide exchange factor 2"
                     /codon_start=1
                     /product="ras-specific guanine nucleotide-releasing factor
                     2"
                     /protein_id="NP_446173.1"
                     /db_xref="GeneID:114513"
                     /db_xref="RGD:69413"
                     /translation="MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWF
                     ALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVL
                     FGHEGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIA
                     ANQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHTHQEEEDPDIKKIKKVQSFMRG
                     WLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMA
                     ASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLN
                     IYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYPMFQIPRYI
                     ITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGC
                     DILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRS
                     SGGKLHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTV
                     VLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTD
                     ICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKL
                     SDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVR
                     ARKLSLTSSLNSRIGALDLTTSSSSSSPTTTVHSPAASPPPHTAVPESAPADRAGDST
                     DMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNNERT
                     CDKEFIIRRTATNRVLNVLRHWVSKHSQDFELNNELKMNVLNLLEEVLRDPDLLPQER
                     KATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFR
                     SIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKW
                     VAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGR
                     FKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIR
                     QFQQTAYRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA"
     misc_feature    2173..2175
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70392; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2176..2178
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70392; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2206..2208
                     /gene="Rasgrf2"
                     /note="Phosphoserine, by CDK5.
                     /evidence=ECO:0000250|UniProtKB:O14827; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2227..2253
                     /gene="Rasgrf2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JE4.1);
                     Region: Regulates proteasomal degradation.
                     /evidence=ECO:0000250"
     misc_feature    2233..2235
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O14827; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2245..2247
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70392; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2401..2403
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70392; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2413..2415
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70392; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    2773..2775
                     /gene="Rasgrf2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70392; propagated from
                     UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site"
     misc_feature    3154..3243
                     /gene="Rasgrf2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99JE4.1);
                     Region: Responsible of the affinity for farnesylated
                     versus geranylgeranylated Ras. /evidence=ECO:0000250"
ORIGIN      
        1 atgcagaaga gcgtgcgcta caacgagggg cacgccctgt acctggcctt cctggcgcgc
       61 aaggagggca ccaagcgcgg tttcctgagc aaaaaggctg ccgaggcgag ccgctggcac
      121 gagaagtggt tcgctctcta tcagaatgtg ctcttttact tcgaaggcga acagagcggc
      181 cgcccagcgg gcatgtacct cctagagggc tgcagctgtg agcggacgcc cgccccacca
      241 aggaccaacg caggacccgc aggcgcccgg gacgcgctgg acaaacagta ttacttcact
      301 gtcctttttg gtcacgaagg tcagaaacca ctggagctgc gctgtgagga ggagcaagca
      361 gggaaagagt ggatggaggc cattcaccaa gccagttacg cagacatttt gattgagagg
      421 gaagtgttaa tgcaaaagta cattcatcta gttcagattg tggagacaga aaaaattgct
      481 gctaaccaac tccgacatca actcgaagat caagataccg aaattgaaag acttaaatca
      541 gagattgttg ctcttaataa gaccaaggaa cggatgcgcc cgtatcatac ccatcaagag
      601 gaggaggatc cagacatcaa gaagatcaag aaggttcaga gcttcatgag agggtggctg
      661 tgcaggagga agtggaagac catcgttcag gactacattt gttcccccca tgctgagagc
      721 atgaggaaga ggaaccagat tgtcttcacg atggtggagg ccgagtcaga atatgtgcac
      781 cagctctaca tcctggtgaa cggtttcctc aggcctctgc gcatggcagc cagctccaag
      841 aagcccccca ttagccatga tgatgtcagc agcattttcc tcaacagtga aacaatcatg
      901 tttcttcatg aaatattcca tcaaggtcta aaggcaaggc tggcaaattg gcccactttg
      961 gttttagctg atctctttga tattttgctg cctatgctca acatttatca agaatttgtg
     1021 cgtaatcatc agtacagcct ccaagtactt gccaactgta agcaaaatag agattttgac
     1081 aagctcttaa agcagtatga aggcaaccct gcctgtgagg gaaggatgct ggagacattc
     1141 ttgacttacc caatgtttca gatccccagg tatatcatca cgctgcacga actcctggct
     1201 cacacccccc atgaacacgt ggagaggaaa agtctggagt tcgctaagtc aaagctggag
     1261 gaactgtcca gagtgatgca cgacgaagtc agtgacaccg aaaacatacg gaaaaatctt
     1321 gccattgaga ggatgatcgt ggagggctgc gacattttgc tagacaccag tcaaactttc
     1381 atccgacaag gttctcttat ccaagtacct tctgtggaga gggggaaact cagtaaagtc
     1441 cgcctgggct ccctgtcttt gaaaaaggaa ggcgagagac aatgtttctt attcacgaag
     1501 cactttctga tctgtacccg aagttcagga ggaaagcttc atttgctcaa gacaggtggg
     1561 gttctctccc tcattcagtg tacgttgatt gaggagccgg acacaagtga tgatgacacc
     1621 aaaggtcctg gtcacatgtt cggacatctg gattttaaaa tcgtcgtgga gcctcctgat
     1681 gctgccccgt tcactgtggt cttgctagca ccttcgcgcc aggagaaggc tgcctggatg
     1741 agcgacatca gccagtgcgt ggacaatatc cgatgcaatg gattgatgac tatagtcttc
     1801 gaagagaatt ctaaagttac tgtgccccat atgataaagt ctgatgcccg tcttcataaa
     1861 gacgacactg acatctgttt cagtaaaaca ctcaattcct gcaaagtgcc ccagatccgc
     1921 tacgccagcg tggagcgcct cttggagcgg ttgacggatt tgcggtttct gagcatcgat
     1981 ttcctcaaca ccttcctgca cacctaccgc attttcacca cggctgccgt agtgctgggg
     2041 aagctctccg acatctacaa gaggcctttc acctccattc ctgtcagatc actagagtta
     2101 ttttttgcca cgagccagaa caacagagaa catttggtcg atggaaaatc cccacgtctt
     2161 tgtcgcaagt tctcttcccc acctcccctg gctgtatcca gaacgtcctc cccagtgagg
     2221 gccagaaagc tgtctttgac atcttccttg aactcaagga tcggagcctt ggacctgact
     2281 acatcctcat cttccagtag tcccaccacc actgtccaca gtcctgctgc gtccccacca
     2341 cctcacactg ctgtcccaga gtctgcacca gccgaccgag caggagactc cacagacatg
     2401 tcaccttgta gatctccctc aaccactccc cggcacctcc gatatcgcca gcctggagga
     2461 caggtagctg acagcaccca ctgtgctgtt tcacctgctt ctgcttttgc gatcgccaca
     2521 gcagcagcag gacatgggag tccgccagga tttaacaacg agaggacatg tgacaaggag
     2581 ttcatcatac ggagaacagc caccaatcga gtcctgaatg tcctccgcca ctgggtttca
     2641 aagcactcac aggattttga actcaataat gaactcaaaa tgaatgttct gaacttgcta
     2701 gaagaagttc tacgagaccc ggaccttctt cctcaagaaa ggaaagccac ggcgaacatc
     2761 ctgagggctc tttcacaaga tgatcaagat gacatccacc taaaattaga ggatataatt
     2821 caaatgacag actgtccaaa ggccgagtgc tttgagacat tgtcagccat ggagctggct
     2881 gagcagatca ctctcctgga ccacattgtt ttcagaagca tcccctatga agagtttctt
     2941 gggcagggct ggatgaagct ggataaaaac gaaaggactc cttatatcat gaaaaccagc
     3001 cagcacttca atgagatgag taacctggtg gcctcccaga taatgaatta tgctgacatc
     3061 agttcccgtg ccaatgccat tgagaagtgg gtagcagtgg cggacatctg ccgatgtcta
     3121 cacaactaca atggtgtgct ggagatcacc tcggccttaa acagaagtgc catctacagg
     3181 ctgaagaaaa cctggaccaa ggtgtccaag cagacaaaag ctctgatgga caaacttcag
     3241 aagactgtct cgtctgaagg aagatttaaa aacctcagag aaactctcaa aaactgtaac
     3301 cccccagctg tcccttacct tgggatgtac ttgacagacc tggcattcat tgaagaaggg
     3361 acaccgaact ttaccgaaga aggccttgtc aatttctcca aaatgcgaat gatatcacac
     3421 atcattcgtg agatacgcca gttccagcag accgcttacc gcatagacca gcagccaaag
     3481 gtcatacaat acctgcttga caaagccctt gtcatagatg aagatacact ctatgagctg
     3541 tcactcaaaa ttgaacctcg actccctgct tga
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.