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NCBI Reference Sequence: NM_053721.1
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LOCUS NM_053721 3573 bp mRNA linear ROD 01-FEB-2021 DEFINITION Rattus norvegicus RAS protein-specific guanine nucleotide-releasing factor 2 (Rasgrf2), mRNA. ACCESSION NM_053721 VERSION NM_053721.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3573) AUTHORS Wu RF, Liao C, Hatoum H, Fu G, Ochoa CD and Terada LS. TITLE RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras JOURNAL Arterioscler Thromb Vasc Biol 37 (1), 98-107 (2017) PUBMED 27856453 REFERENCE 2 (bases 1 to 3573) AUTHORS Jin SX and Feig LA. TITLE Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling JOURNAL PLoS One 5 (7), e11732 (2010) PUBMED 20661302 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3573) AUTHORS Zhang GC, Hoffmann J, Parelkar NK, Liu XY, Mao LM, Fibuch EE and Wang JQ. TITLE Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo JOURNAL Neurosci Lett 427 (2), 117-121 (2007) PUBMED 17931779 REMARK GeneRIF: data identify the Ras activator, Ras-GRF1, although not Ras-GRF2, as a susceptible target to cocaine stimulation in striatal neurons REFERENCE 4 (bases 1 to 3573) AUTHORS Tian X, Gotoh T, Tsuji K, Lo EH, Huang S and Feig LA. TITLE Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB JOURNAL EMBO J 23 (7), 1567-1575 (2004) PUBMED 15029245 REFERENCE 5 (bases 1 to 3573) AUTHORS Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Munoz MT, Egea G, Lafarga M and Crespo P. TITLE Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors JOURNAL Mol Cell Biol 24 (4), 1516-1530 (2004) PUBMED 14749369 REMARK GeneRIF: RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex REFERENCE 6 (bases 1 to 3573) AUTHORS Laes JF, Quan X, Ravoet M, Stieber D, Van Vooren P, Van Reeth T, Szpirer J and Szpirer C. TITLE Analysis of candidate genes included in the mammary cancer susceptibility 1 (Mcs1) region JOURNAL Mamm Genome 12 (3), 199-206 (2001) PUBMED 11252168 REFERENCE 7 (bases 1 to 3573) AUTHORS Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE and Lowy DR. TITLE Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf JOURNAL Mol Cell Biol 19 (7), 4611-4622 (1999) PUBMED 10373510 REFERENCE 8 (bases 1 to 3573) AUTHORS Fan WT, Koch CA, de Hoog CL, Fam NP and Moran MF. TITLE The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways JOURNAL Curr Biol 8 (16), 935-938 (1998) PUBMED 9707409 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ276774.1. [WARNING] On Mar 10, 2021 this sequence was replaced by NM_053721.2. Summary: human homolog is involved in stimulating the conversion of the GDP-bound form of Ras into the active form [RGD, Feb 2006]. ##Evidence-Data-START## Transcript exon combination :: AJ276774.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA5756307, SAMEA5760383 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..3573 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="2" /map="2q12" gene 1..3573 /gene="Rasgrf2" /note="RAS protein-specific guanine nucleotide-releasing factor 2" /db_xref="GeneID:114513" /db_xref="RGD:69413" CDS 1..3573 /gene="Rasgrf2" /note="ras-GRF2; guanine nucleotide-releasing factor 2; ras guanine nucleotide exchange factor 2" /codon_start=1 /product="ras-specific guanine nucleotide-releasing factor 2" /protein_id="NP_446173.1" /db_xref="GeneID:114513" /db_xref="RGD:69413" /translation="MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWF ALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVL FGHEGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIA ANQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHTHQEEEDPDIKKIKKVQSFMRG WLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMA ASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLN IYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYPMFQIPRYI ITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGC DILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRS SGGKLHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTV VLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTD ICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKL SDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVR ARKLSLTSSLNSRIGALDLTTSSSSSSPTTTVHSPAASPPPHTAVPESAPADRAGDST DMSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNNERT CDKEFIIRRTATNRVLNVLRHWVSKHSQDFELNNELKMNVLNLLEEVLRDPDLLPQER KATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFR SIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKW VAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGR FKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIR QFQQTAYRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA" misc_feature 2173..2175 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P70392; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2176..2178 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P70392; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2206..2208 /gene="Rasgrf2" /note="Phosphoserine, by CDK5. /evidence=ECO:0000250|UniProtKB:O14827; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2227..2253 /gene="Rasgrf2" /note="propagated from UniProtKB/Swiss-Prot (Q99JE4.1); Region: Regulates proteasomal degradation. /evidence=ECO:0000250" misc_feature 2233..2235 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:O14827; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2245..2247 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P70392; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2401..2403 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P70392; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2413..2415 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P70392; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 2773..2775 /gene="Rasgrf2" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:P70392; propagated from UniProtKB/Swiss-Prot (Q99JE4.1); phosphorylation site" misc_feature 3154..3243 /gene="Rasgrf2" /note="propagated from UniProtKB/Swiss-Prot (Q99JE4.1); Region: Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250" ORIGIN 1 atgcagaaga gcgtgcgcta caacgagggg cacgccctgt acctggcctt cctggcgcgc 61 aaggagggca ccaagcgcgg tttcctgagc aaaaaggctg ccgaggcgag ccgctggcac 121 gagaagtggt tcgctctcta tcagaatgtg ctcttttact tcgaaggcga acagagcggc 181 cgcccagcgg gcatgtacct cctagagggc tgcagctgtg agcggacgcc cgccccacca 241 aggaccaacg caggacccgc aggcgcccgg gacgcgctgg acaaacagta ttacttcact 301 gtcctttttg gtcacgaagg tcagaaacca ctggagctgc gctgtgagga ggagcaagca 361 gggaaagagt ggatggaggc cattcaccaa gccagttacg cagacatttt gattgagagg 421 gaagtgttaa tgcaaaagta cattcatcta gttcagattg tggagacaga aaaaattgct 481 gctaaccaac tccgacatca actcgaagat caagataccg aaattgaaag acttaaatca 541 gagattgttg ctcttaataa gaccaaggaa cggatgcgcc cgtatcatac ccatcaagag 601 gaggaggatc cagacatcaa gaagatcaag aaggttcaga gcttcatgag agggtggctg 661 tgcaggagga agtggaagac catcgttcag gactacattt gttcccccca tgctgagagc 721 atgaggaaga ggaaccagat tgtcttcacg atggtggagg ccgagtcaga atatgtgcac 781 cagctctaca tcctggtgaa cggtttcctc aggcctctgc gcatggcagc cagctccaag 841 aagcccccca ttagccatga tgatgtcagc agcattttcc tcaacagtga aacaatcatg 901 tttcttcatg aaatattcca tcaaggtcta aaggcaaggc tggcaaattg gcccactttg 961 gttttagctg atctctttga tattttgctg cctatgctca acatttatca agaatttgtg 1021 cgtaatcatc agtacagcct ccaagtactt gccaactgta agcaaaatag agattttgac 1081 aagctcttaa agcagtatga aggcaaccct gcctgtgagg gaaggatgct ggagacattc 1141 ttgacttacc caatgtttca gatccccagg tatatcatca cgctgcacga actcctggct 1201 cacacccccc atgaacacgt ggagaggaaa agtctggagt tcgctaagtc aaagctggag 1261 gaactgtcca gagtgatgca cgacgaagtc agtgacaccg aaaacatacg gaaaaatctt 1321 gccattgaga ggatgatcgt ggagggctgc gacattttgc tagacaccag tcaaactttc 1381 atccgacaag gttctcttat ccaagtacct tctgtggaga gggggaaact cagtaaagtc 1441 cgcctgggct ccctgtcttt gaaaaaggaa ggcgagagac aatgtttctt attcacgaag 1501 cactttctga tctgtacccg aagttcagga ggaaagcttc atttgctcaa gacaggtggg 1561 gttctctccc tcattcagtg tacgttgatt gaggagccgg acacaagtga tgatgacacc 1621 aaaggtcctg gtcacatgtt cggacatctg gattttaaaa tcgtcgtgga gcctcctgat 1681 gctgccccgt tcactgtggt cttgctagca ccttcgcgcc aggagaaggc tgcctggatg 1741 agcgacatca gccagtgcgt ggacaatatc cgatgcaatg gattgatgac tatagtcttc 1801 gaagagaatt ctaaagttac tgtgccccat atgataaagt ctgatgcccg tcttcataaa 1861 gacgacactg acatctgttt cagtaaaaca ctcaattcct gcaaagtgcc ccagatccgc 1921 tacgccagcg tggagcgcct cttggagcgg ttgacggatt tgcggtttct gagcatcgat 1981 ttcctcaaca ccttcctgca cacctaccgc attttcacca cggctgccgt agtgctgggg 2041 aagctctccg acatctacaa gaggcctttc acctccattc ctgtcagatc actagagtta 2101 ttttttgcca cgagccagaa caacagagaa catttggtcg atggaaaatc cccacgtctt 2161 tgtcgcaagt tctcttcccc acctcccctg gctgtatcca gaacgtcctc cccagtgagg 2221 gccagaaagc tgtctttgac atcttccttg aactcaagga tcggagcctt ggacctgact 2281 acatcctcat cttccagtag tcccaccacc actgtccaca gtcctgctgc gtccccacca 2341 cctcacactg ctgtcccaga gtctgcacca gccgaccgag caggagactc cacagacatg 2401 tcaccttgta gatctccctc aaccactccc cggcacctcc gatatcgcca gcctggagga 2461 caggtagctg acagcaccca ctgtgctgtt tcacctgctt ctgcttttgc gatcgccaca 2521 gcagcagcag gacatgggag tccgccagga tttaacaacg agaggacatg tgacaaggag 2581 ttcatcatac ggagaacagc caccaatcga gtcctgaatg tcctccgcca ctgggtttca 2641 aagcactcac aggattttga actcaataat gaactcaaaa tgaatgttct gaacttgcta 2701 gaagaagttc tacgagaccc ggaccttctt cctcaagaaa ggaaagccac ggcgaacatc 2761 ctgagggctc tttcacaaga tgatcaagat gacatccacc taaaattaga ggatataatt 2821 caaatgacag actgtccaaa ggccgagtgc tttgagacat tgtcagccat ggagctggct 2881 gagcagatca ctctcctgga ccacattgtt ttcagaagca tcccctatga agagtttctt 2941 gggcagggct ggatgaagct ggataaaaac gaaaggactc cttatatcat gaaaaccagc 3001 cagcacttca atgagatgag taacctggtg gcctcccaga taatgaatta tgctgacatc 3061 agttcccgtg ccaatgccat tgagaagtgg gtagcagtgg cggacatctg ccgatgtcta 3121 cacaactaca atggtgtgct ggagatcacc tcggccttaa acagaagtgc catctacagg 3181 ctgaagaaaa cctggaccaa ggtgtccaag cagacaaaag ctctgatgga caaacttcag 3241 aagactgtct cgtctgaagg aagatttaaa aacctcagag aaactctcaa aaactgtaac 3301 cccccagctg tcccttacct tgggatgtac ttgacagacc tggcattcat tgaagaaggg 3361 acaccgaact ttaccgaaga aggccttgtc aatttctcca aaatgcgaat gatatcacac 3421 atcattcgtg agatacgcca gttccagcag accgcttacc gcatagacca gcagccaaag 3481 gtcatacaat acctgcttga caaagccctt gtcatagatg aagatacact ctatgagctg 3541 tcactcaaaa ttgaacctcg actccctgct tga //
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