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Rattus norvegicus HtrA serine peptidase 4 (Htra4), mRNA

NCBI Reference Sequence: NM_001107321.3

FASTA Graphics 

LOCUS       NM_001107321            2256 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus HtrA serine peptidase 4 (Htra4), mRNA.
ACCESSION   NM_001107321 XM_001071971 XM_224963
VERSION     NM_001107321.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2256)
  AUTHORS   Ketteler,R., Sun,Z., Kovacs,K.F., He,W.W. and Seed,B.
  TITLE     A pathway sensor for genome-wide screens of intracellular
            proteolytic cleavage
  JOURNAL   Genome Biol 9 (4), R64 (2008)
   PUBMED   18387192
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Mar 31, 2024 this sequence version replaced NM_001107321.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.59325.1,
                                           SRR26643288.56100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               JAXUCZ010000016.1  73704255-73704870
            617-716             JAXUCZ010000016.1  73705251-73705350
            717-921             JAXUCZ010000016.1  73706084-73706288
            922-1116            JAXUCZ010000016.1  73709154-73709348
            1117-1149           JAXUCZ010000016.1  73709755-73709787
            1150-1264           JAXUCZ010000016.1  73711910-73712024
            1265-1322           JAXUCZ010000016.1  73712367-73712424
            1323-1418           JAXUCZ010000016.1  73712767-73712862
            1419-2256           JAXUCZ010000016.1  73716885-73717722
FEATURES             Location/Qualifiers
     source          1..2256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..2256
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /note="HtrA serine peptidase 4"
                     /db_xref="GeneID:306564"
                     /db_xref="RGD:1306242"
     exon            1..616
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /note="upstream in-frame stop codon"
     CDS             118..1584
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /note="probable serine protease HTRA4; high-temperature
                     requirement factor A4; serine protease HTR4"
                     /codon_start=1
                     /product="serine protease HTR4 precursor"
                     /protein_id="NP_001100791.1"
                     /db_xref="GeneID:306564"
                     /db_xref="RGD:1306242"
                     /translation="MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPC
                     PDACDPTRCPPLPSCSAGSALVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPF
                     SREPSGRAWLGTCGCAEGAEGAAVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQK
                     GACGDSGTTRAGRLRTKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIV
                     SEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDHKLDLALIKIEPDTDLPVLLL
                     GRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDIDYIQTDAIINH
                     GNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGKAPLQKKYL
                     GLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQP
                     VTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN"
     sig_peptide     118..222
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     223..1581
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /product="Serine protease HTR4. /id=PRO_0000417601"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZKF5.1)"
     misc_feature    754..1236
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /note="propagated from UniProtKB/Swiss-Prot (D3ZKF5.1);
                     Region: Serine protease. /evidence=ECO:0000250"
     exon            617..716
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            717..921
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1116
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1149
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1264
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1322
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1418
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..2256
                     /gene="Htra4"
                     /gene_synonym="RGD1306242"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgtccttt ataaagtctg gaggccggca gaggcagcat ccaggccagg aaaagaacgt
       61 gttgctcatt tcggcccagt tgtgagccca gagtgaactg gaaaagtaga atcaacgatg
      121 tcaaggagca agatgagctc ccagcggttg tgggctgtgc gagcacagtt tctcttgctg
      181 tggctgctgc tctgggccgc gcctgttccg tgggctgagg ccaggaggtc tagagtctcc
      241 ttgccctgcc cggacgcctg cgatcccacg cgctgcccgc ctctgcctag ctgctcggcc
      301 ggctcggcgc tagtgccaga tcgctgcggc tgctgccaag tgtgcgccgc ggtcgagggc
      361 caggagtgtg gcggggcgcg gggccggccg tgcgtcccgg ggctgcgctg cggcgccccg
      421 ttctcccggg agccctcagg gcgcgcgtgg ctgggcacct gcggttgcgc ggagggtgca
      481 gagggcgcgg cggtgtgcgg cagcgacggg cgcacttacc ccagcctgtg cgcgctccgc
      541 aaggagaacc gagcggctcg ccagcggggt gcgctcccgg ctgtgccagt gcagaaaggt
      601 gcctgcggcg actcagggac cacaagagca gggcggctcc ggacaaagta caacttcatc
      661 gctgccgtgg tggagaaggt ggcaccgtct gtggttcact tgcagctgtt ccgcagatca
      721 cctctcacca accaggaaat cccttcatcc agcggttccg ggttcatagt gtctgaggat
      781 ggcctcattg tcaccaatgc ccatgtcctc accaaccagc agaagatcca ggtagagctc
      841 cagaacgggg ctcagtatga agccactgtc aaagacatcg accataaact ggaccttgca
      901 ctgattaaga tcgagccaga tactgacctt ccagtactgt tgctgggaag atcctctgac
      961 ctccgggccg gagagtttgt ggtggctttg ggtagcccat tttccctgca gaacactgtg
     1021 actgccggga ttgtcagcac cacacagaga ggcggcaaag agttgggact gaaggactca
     1081 gacatagact atatccagac ggacgccatc attaaccacg gaaattctgg gggtccactg
     1141 gtgaacttgg atggcgatgt gatcggtata aacaccctga aggtgaccgc agggatctct
     1201 tttgcaatcc cctcagatag gatcagacag ttcctggcag actatcatga gcgccagttg
     1261 aaaggaaagg ctcccttgca gaagaaatac ctgggtctta gaatgttgcc cctcactctg
     1321 aacctccttc aggaaatgaa gaggcaagat cccgatttcc ctgatgtgag ctctggagtt
     1381 tttgtatatg aagtgattca aggatcggcc gctgcaagct cggggttgag agaccatgat
     1441 gtaattgtca gcataaacgg gcagcctgtc acgaccacaa ccgatgtcat tgaagctgtt
     1501 aaggacaatg cctttctctc catcattgtt cttcgaggaa gccaaacctt gtttctgaca
     1561 gtcacacctg aaataatcaa ttaagcacct tactttgaga aactgcctag caaaaccagt
     1621 tatattacct ggtttctatc gaagacgaac cagagatggc aggttcttct gggtatcaag
     1681 aaaagtggat gctttaaatg tataagtaca tgtgtgtgtg atacacacac tcgtgcacat
     1741 gtgtacacac gtgtatacac acacacacac acacacacac acacacacac acacacacat
     1801 tctcatggat cctgagggat taagcatgct cttctactac aaaaactttc gtgactcaag
     1861 tggccgcagc tatggtgatc agagaaaaag taaagacagt aagaatggga aaacaggaga
     1921 ctcctaacta aatcttcaca gggtgcttta cttaccgtct atatagccac taactgatat
     1981 gtcacacaca tgtacaaaca atctacctac tagatctgaa tctggagtaa agaggcaatc
     2041 atgttttaaa taacacccct ctgtatgctg aatttcccgg ggtatatcca ctttgggcca
     2101 gggtttgtgg atagaaaggt cgtcaactct aagatagatt acaactgatg acgtcagacc
     2161 accacacagg aatatgacca ttttagcggt agaaactatc ctggacctct ggtgtttctg
     2221 agaatgtctt ctattaaaac aattttttga accatt
//
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Reference sequence information

  • RefSeq protein product
    See the reference protein sequence for serine protease HTR4 precursor (NP_001100791.1).

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