LOCUS NM_012950 3442 bp mRNA linear ROD 10-DEC-2024
DEFINITION Rattus norvegicus coagulation factor II (thrombin) receptor (F2r),
mRNA.
ACCESSION NM_012950
VERSION NM_012950.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3442)
AUTHORS El-Gazar,A.A., Soubh,A.A., Abdallah,D.M., Ragab,G.M. and
El-Abhar,H.S.
TITLE Elucidating PAR1 as a therapeutic target for delayed traumatic
brain injury: Unveiling the PPAR-gamma/Nrf2/HO-1/GPX4 axis to
suppress ferroptosis and alleviate NLRP3 inflammasome activation in
rats
JOURNAL Int Immunopharmacol 139, 112774 (2024)
PUBMED 39067398
REMARK GeneRIF: Elucidating PAR1 as a therapeutic target for delayed
traumatic brain injury: Unveiling the PPAR-gamma/Nrf2/HO-1/GPX4
axis to suppress ferroptosis and alleviate NLRP3 inflammasome
activation in rats.
REFERENCE 2 (bases 1 to 3442)
AUTHORS Bohovyk,R., Khedr,S., Levchenko,V., Stefanenko,M., Semenikhina,M.,
Kravtsova,O., Isaeva,E., Geurts,A.M., Klemens,C.A., Palygin,O. and
Staruschenko,A.
TITLE Protease-Activated Receptor 1-Mediated Damage of Podocytes in
Diabetic Nephropathy
JOURNAL Diabetes 72 (12), 1795-1808 (2023)
PUBMED 37722138
REMARK GeneRIF: Protease-Activated Receptor 1-Mediated Damage of Podocytes
in Diabetic Nephropathy.
REFERENCE 3 (bases 1 to 3442)
AUTHORS Onimaru,H., Fukushi,I., Ikeda,K., Yazawa,I., Takeda,K., Okada,Y.
and Izumizaki,M.
TITLE Cell Responses of the Ventrolateral Medulla to PAR1 Activation and
Changes in Respiratory Rhythm in Newborn Rat En Bloc
Brainstem-Spinal Cord Preparations
JOURNAL Neuroscience 528, 89-101 (2023)
PUBMED 37557948
REMARK GeneRIF: Cell Responses of the Ventrolateral Medulla to PAR1
Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc
Brainstem-Spinal Cord Preparations.
REFERENCE 4 (bases 1 to 3442)
AUTHORS Xu,P., Zhan,H., Zhang,R., Xu,X.J., Zhang,Y., Le,Y. and Bi,J.G.
TITLE Early growth response factor 1 upregulates pro-fibrotic genes
through activation of TGF-beta1/Smad pathway via transcriptional
regulation of PAR1 in high-glucose treated HK-2 cells
JOURNAL Mol Cell Endocrinol 572, 111953 (2023)
PUBMED 37172885
REMARK GeneRIF: Early growth response factor 1 upregulates pro-fibrotic
genes through activation of TGF-beta1/Smad pathway via
transcriptional regulation of PAR1 in high-glucose treated HK-2
cells.
REFERENCE 5 (bases 1 to 3442)
AUTHORS Wang,A., Gu,X., Wang,C., Li,Y., Deng,F., Fang,J., Chen,N., Li,Q.
and Tang,L.
TITLE TRAP-induced PAR1 expression with its mechanism during AMI in a rat
model
JOURNAL BMC Cardiovasc Disord 23 (1), 97 (2023)
PUBMED 36809978
REMARK GeneRIF: TRAP-induced PAR1 expression with its mechanism during AMI
in a rat model.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3442)
AUTHORS Capers,Q. 4th, Laursen,J.B., Fukui,T., Rajagopalan,S., Mori,I.,
Lou,P., Freeman,B.A., Berrington,W.R., Griendling,K.K.,
Harrison,D.G., Runge,M.S., Alexander,R.W. and Taylor,W.R.
TITLE Vascular thrombin receptor regulation in hypertensive rats
JOURNAL Circ Res 80 (6), 838-844 (1997)
PUBMED 9168786
REFERENCE 7 (bases 1 to 3442)
AUTHORS Molino,M., Bainton,D.F., Hoxie,J.A., Coughlin,S.R. and Brass,L.F.
TITLE Thrombin receptors on human platelets. Initial localization and
subsequent redistribution during platelet activation
JOURNAL J Biol Chem 272 (9), 6011-6017 (1997)
PUBMED 9038223
REFERENCE 8 (bases 1 to 3442)
AUTHORS Nelken,N.A., Soifer,S.J., O'Keefe,J., Vu,T.K., Charo,I.F. and
Coughlin,S.R.
TITLE Thrombin receptor expression in normal and atherosclerotic human
arteries
JOURNAL J Clin Invest 90 (4), 1614-1621 (1992)
PUBMED 1328304
REFERENCE 9 (bases 1 to 3442)
AUTHORS Zhong,C., Hayzer,D.J., Corson,M.A. and Runge,M.S.
TITLE Molecular cloning of the rat vascular smooth muscle thrombin
receptor. Evidence for in vitro regulation by basic fibroblast
growth factor
JOURNAL J Biol Chem 267 (24), 16975-16979 (1992)
PUBMED 1324917
REFERENCE 10 (bases 1 to 3442)
AUTHORS Vu,T.K., Hung,D.T., Wheaton,V.I. and Coughlin,S.R.
TITLE Molecular cloning of a functional thrombin receptor reveals a novel
proteolytic mechanism of receptor activation
JOURNAL Cell 64 (6), 1057-1068 (1991)
PUBMED 1672265
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC085759.1 and CV116337.1.
On Nov 23, 2005 this sequence version replaced NM_012950.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript is intronless :: BC085759.1 [ECO:0000345]
RNAseq introns :: single sample supports all introns
SAMN12840105, SAMN12840110
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2790 BC085759.1 1-2790
2791-2943 CV116337.1 590-742
2944-3442 BC085759.1 2943-3441
FEATURES Location/Qualifiers
source 1..3442
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="2"
/map="2q12"
gene 1..3442
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="coagulation factor II (thrombin) receptor"
/db_xref="GeneID:25439"
/db_xref="RGD:2586"
exon 1..153
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/inference="alignment:Splign:2.1.0"
misc_feature 15..17
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="upstream in-frame stop codon"
CDS 66..1364
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="proteinase-activated receptor 1; PAR-1; Thrombin
receptor; protease-activated receptor 1; coagulation
factor II receptor"
/codon_start=1
/product="proteinase-activated receptor 1 precursor"
/protein_id="NP_037082.2"
/db_xref="GeneID:25439"
/db_xref="RGD:2586"
/translation="MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNP
RSFFLRNPSEDTFEQFPLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGY
LTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVS
VLPFKISYYFSGTDWQFGSGMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPIQSL
SWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQVPGLNITTCHDVLNETLLHGFYSY
YFSAFSAIFFLVPLIISTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFG
PTNVLLIVHYLLLSDSPGTETAYFAYLLCVCVSSVSCCIDPLIYYYASSECQKHLYSI
LCCRESSDSNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA"
sig_peptide 66..128
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
misc_feature 198..203
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="Cleavage, by thrombin and CTSG.
/evidence=ECO:0000250|UniProtKB:P25116; propagated from
UniProtKB/Swiss-Prot (P26824.1); cleavage site"
mat_peptide 201..1361
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/product="Proteinase-activated receptor 1.
/id=PRO_0000012747"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1)"
misc_feature 270..272
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26824.1); glycosylation site"
misc_feature 309..311
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26824.1); glycosylation site"
misc_feature 393..470
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1);
transmembrane region"
misc_feature 498..557
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1);
transmembrane region"
misc_feature 615..680
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1);
transmembrane region"
misc_feature 741..803
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1);
transmembrane region"
misc_feature 834..836
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26824.1); glycosylation site"
misc_feature 861..863
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26824.1); glycosylation site"
misc_feature 891..950
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1);
transmembrane region"
misc_feature 1020..1088
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="propagated from UniProtKB/Swiss-Prot (P26824.1);
transmembrane region"
misc_feature 1338..1340
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P25116; propagated from
UniProtKB/Swiss-Prot (P26824.1); phosphorylation site"
exon 154..3423
/gene="F2r"
/gene_synonym="Par1; TRGPC"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 gaacgagctg ctcctaagaa agtaggcgac cgcggtcgcc gggccgcgcg ggcagcctcg
61 ggacaatggg gccccggcgc ttgctgctcg tcgcggtcgg cctcagcctg tgcggtcctt
121 tgctgtcttc ccgcgttcct atgagacagc cagaatctga gaggatgtat gctacgccgt
181 atgctacgcc aaacccccgc tcattttttc tcaggaatcc cagtgaagat acatttgaac
241 agttccccct aggggatgag gaggagaaaa atgaaagcat accgctcgag ggcagggcag
301 tctacttaaa taaaagccgt tttcctccca tgccgcctcc tcccttcatc tccgaggacg
361 cctccggata tctgaccagc ccctggctga cgctcttcat accctccgtg tacacgtttg
421 tgttcatagt cagccttccc ctgaacatcc tggccatcgc tgtgtttgtc tttcggatga
481 aggtcaagaa gccggccgtg gtgtacatgc tgcacctggc catggccgat gtcctcttcg
541 tgtccgtgct ccccttcaag atcagctact acttctccgg caccgattgg cagttcgggt
601 ccggaatgtg tcgcttcgcc accgcagcgt tttattgtaa catgtacgcc tccatcatgc
661 tcatgacagt cataagcatt gaccggttcc tggcagtggt gtaccccatc cagtccctgt
721 cctggcgcac tctgggccga gccaacttca cctgcgtggt catctgggtg atggccatca
781 tgggggtggt gcccctcctc ctcaaagagc agaccaccca ggttccgggg ctcaacatca
841 ccacctgcca cgacgtcctc aacgagaccc tgctgcatgg cttttactcg tactatttct
901 ccgccttctc cgccatcttc tttcttgtgc cgttgatcat ttccacagtc tgctacacgt
961 ccatcatccg atgcctcagc tcctccgcgg tggcgaaccg gagcaagaag tcgcgggctt
1021 tgttcctgtc cgccgccgtg ttctgcatct tcatcgtctg ctttgggccc accaacgtcc
1081 tcctgattgt gcactacctg ctcctctccg acagtcctgg cacagagacg gcctattttg
1141 cttacctcct ctgcgtctgc gtgagcagcg tgagctgctg catcgacccc ttgatttact
1201 actatgcctc ctccgagtgc cagaagcacc tttacagcat tttgtgctgc agagaaagct
1261 ctgattccaa cagttgcaac agcaccggcc agctgatgcc cagtaagatg gatacctgct
1321 ctagccacct gaataatagc atatacaaaa agctactagc ttagggaaag ggtggctgga
1381 aggttccatg aagaaaaggt tggaaagtga acagctgggg aacccccatc agtccctggc
1441 aagaactgta ttgacttcaa cgccttaaga aaaccgccaa cgtctgattt gcatgcatac
1501 ttcttacaag tgctatcaag tgtatagatt ggataatcac cagcaaggtg atgggaacgg
1561 agtcaaggtt tccagtgttg cttagtgctg ggatagtagt tgagcgtcac ctcttctata
1621 tctaggtgac tttaacatac aggtggtgtg cacacacaca gtggcagtgc agggtggatt
1681 ctgcgctttg acgctttctt gtttattccc tggcagttgc tatagaaata atctgattct
1741 ctgacttaat aaagtctggg ttggtggatg ctagccctgg gcagctgaag accccagtga
1801 tagggaagaa gcccatagtt tagacttaag acagcttttg cctatgtgtc tatatttata
1861 tattttcaaa ttatttgata gtaatgttta gtgatggaag gatgagacag tattacctgt
1921 gtaggggaag gtcttgaaca accacagttt aagaattatc aaagcagttg aaaagccccg
1981 ttttgatacg caatttactt acaaaatacg tggaccaaga ctgagcataa gactcgccag
2041 gaatgtaaga aacctttcaa agcagccaag cctgataact agacacagcc atctgcatgg
2101 aggcctctga gcatgaggta tatcataccc cttcagctat gcctcccaga gagcagagat
2161 gaggaccacc aggcccactc caccctgcta ggggtctcat ttgctgtgaa ctgattatgt
2221 caattagaaa ttggcaaggg aggggatgcc atcttgggag gcaataacac ctgcacatct
2281 gacaatcgga gaaaggtgtg tttacatcca gcagctgtcc cgcaaggctg gcccttgcac
2341 agacagacac acccatgtgc cctggtcaca ctgttggata gtgggccgta gactgactga
2401 ctgtcggaga atagctgagt cctgccctta ctcaggcagc gcagagagct ggcacacggt
2461 cagctgtgac gtatgcgctg caaaccatcg cacatagaag ttgtcattag ctggatgtca
2521 ccaagcatat gtcacacaag cacggcctat cagctaaacc gctttggata tctgagtctc
2581 tgcttccggt aactatagat tgggataaag acacaataca agatgtatat ttttaataca
2641 taagcccttc agtctacaat aattagatgc tatttattta caaatgtttt gttaaaaatt
2701 actcagatca gcctggcatt ttgtcgcatg cctttaagcc cagtaggtgg gaggcagagg
2761 cagtcagatg gtaaacaact tttttttttt tgttcttttt ttcagagctg gggaccgaac
2821 ccaggacctt gtgcttgctc ggcaagtgct ctaccactga gctaaatccc caaccccggt
2881 aaacaacttt tttaagaagc aagcaaacac actgaagtcc agttttaaga aatatatagg
2941 tcagtttggt taaaaataat aataatgaaa ggaaatttca ttgattgaaa ttgattgcaa
3001 tgtaggaaaa ttagcctgta tttctctcaa gagttactga agttgttttt aaagtctttt
3061 aatgccacag tgactaacaa gcatataaaa atcttcatgc ctttgacaaa ttaatttaga
3121 agttaattta aaacatatcc ttttcctggt taaaaaaata tgttggcatt ttaagcagat
3181 aagactagaa agtatttaag aaaacaaagt atttcccaat actgtagaat agcttccatg
3241 aaactcccct agttgtctgg ttaactctgt tcctgtgttg atttatctaa atcattgact
3301 ccctgtcctg tgctctgtga cttaacgtaa ctgttaccac tgcacttgtg aactttcgtg
3361 tcattgtttt gtgttcaccc tcttttttta aaaaatatat taataaacta aaaacctgct
3421 tggaaaaaaa aaaaaaaaaa aa
//