LOCUS NM_001428684 3302 bp mRNA linear ROD 20-MAR-2024
DEFINITION Rattus norvegicus DSN1 component of MIS12 kinetochore complex
(Dsn1), transcript variant 3, mRNA.
ACCESSION NM_001428684
VERSION NM_001428684.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3302)
AUTHORS Sun,C., Huang,S., Ju,W., Hou,Y., Wang,Z., Liu,Y., Wu,L. and He,X.
TITLE Elevated DSN1 expression is associated with poor survival in
patients with hepatocellular carcinoma
JOURNAL Hum Pathol 81, 113-120 (2018)
PUBMED 30136646
REFERENCE 2 (bases 1 to 3302)
AUTHORS Chuang,T.P., Wang,J.Y., Jao,S.W., Wu,C.C., Chen,J.H., Hsiao,K.H.,
Lin,C.Y., Chen,S.H., Su,S.Y., Chen,Y.J., Chen,Y.T., Wu,D.C. and
Li,L.H.
TITLE Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal
adenoma to carcinoma progression
JOURNAL Oncotarget 7 (29), 45803-45818 (2016)
PUBMED 27329586
REFERENCE 3 (bases 1 to 3302)
AUTHORS Kline,S.L., Cheeseman,I.M., Hori,T., Fukagawa,T. and Desai,A.
TITLE The human Mis12 complex is required for kinetochore assembly and
proper chromosome segregation
JOURNAL J Cell Biol 173 (1), 9-17 (2006)
PUBMED 16585270
REFERENCE 4 (bases 1 to 3302)
AUTHORS Cheeseman,I.M., Niessen,S., Anderson,S., Hyndman,F., Yates,J.R.
3rd, Oegema,K. and Desai,A.
TITLE A conserved protein network controls assembly of the outer
kinetochore and its ability to sustain tension
JOURNAL Genes Dev 18 (18), 2255-2268 (2004)
PUBMED 15371340
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000003.1.
##Evidence-Data-START##
Transcript exon combination :: SRR26360186.1786144.1,
SRR26360172.1027099.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760389 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-97 JAXUCZ010000003.1 166085824-166085920 c
98-123 JAXUCZ010000003.1 166084679-166084704 c
124-487 JAXUCZ010000003.1 166084041-166084404 c
488-561 JAXUCZ010000003.1 166081950-166082023 c
562-634 JAXUCZ010000003.1 166080949-166081021 c
635-725 JAXUCZ010000003.1 166079777-166079867 c
726-785 JAXUCZ010000003.1 166077939-166077998 c
786-863 JAXUCZ010000003.1 166077479-166077556 c
864-1011 JAXUCZ010000003.1 166076275-166076422 c
1012-1099 JAXUCZ010000003.1 166075407-166075494 c
1100-3302 JAXUCZ010000003.1 166072775-166074977 c
FEATURES Location/Qualifiers
source 1..3302
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="3"
/map="3q42"
gene 1..3302
/gene="Dsn1"
/note="DSN1 component of MIS12 kinetochore complex"
/db_xref="GeneID:499933"
/db_xref="RGD:1565179"
exon 1..97
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 98..123
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 124..487
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
misc_feature 151..153
/gene="Dsn1"
/note="upstream in-frame stop codon"
CDS 157..1185
/gene="Dsn1"
/note="isoform 2 is encoded by transcript variant 3;
kinetochore-associated protein DSN1 homolog; DSN1, MIND
kinetochore complex component, homolog; DSN1, MIS12
kinetochore complex component; DSN1 homolog, MIS12
kinetochore complex component"
/codon_start=1
/product="kinetochore-associated protein DSN1 homolog
isoform 2"
/protein_id="NP_001415613.1"
/db_xref="GeneID:499933"
/db_xref="RGD:1565179"
/translation="MLDQGPTMSETQDRPLQPSLEPLEALPRSSAYQEMMAQGTSEEQ
NHLGRSPREGEGCGADPQEGPQLRSFHLSPQEQSARHRDRRQSWRRASMKEINRRKSL
APFHPGITELSRSISMKLAQSQRLGALLLSSFQFSVEKLEPFLKNTKDFSLECFRAKA
SSLSEELKHFTDRLGNDGTLQKCFVEDSKEKAPDFSLEASVAEVKEYITKFSLERQAW
DRLLLQYQNEVPPEEMPRGSTETKINEVNVDPAAYLRSSQKEVLNTKPDYQRIVQSQN
EVFAYMELVMDELQGAVKQLQAFMDESTQYLQKVSVQLKKRSMEQLDSSPARKLLKLH
LQSSSTTQ"
exon 488..561
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 562..634
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 635..725
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 726..785
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 786..863
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 864..1011
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 1012..1099
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
exon 1100..3302
/gene="Dsn1"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 attcggcggg agtttcggaa gtagctgcgg cagcgcggaa cctggaacta gactaacggg
61 gaagaccacc ctctgtggtg acgcccagtc tgcagaggat gacttcggtg accaaatcag
121 aaggctcgat tttatatttt gacttttctg tgacaaatgc tagaccaggg accaacgatg
181 tcggagactc aggatcgtcc attgcaacca agtctcgagc ctttggaagc attgcctcga
241 tcctctgcct accaggaaat gatggcacaa ggcacttcag aggaacaaaa ccaccttggc
301 cggagcccca gagaggggga aggttgtggt gctgaccccc aggagggacc tcagttgagg
361 tcctttcatt tgtctcctca agaacagtct gcccgtcaca gagacagaag gcagtcctgg
421 aggcgagcaa gcatgaaaga gataaaccgg cggaagtcgt tggctccttt tcacccgggc
481 atcacagagc tcagcaggtc aatcagtatg aagttagcac agagccaacg gcttggcgcc
541 ctcctgctct ccagcttcca gttctctgtt gaaaaacttg aacctttctt aaagaacact
601 aaggacttca gccttgaatg ttttagagcc aaagcatctt ctctctctga agaattgaaa
661 cattttacag acaggctggg aaatgatgga actctacaaa aatgttttgt tgaagattca
721 aaagaaaaag caccagattt ctcactggaa gcatcagtag ctgaggtgaa agaatatata
781 acaaagtttt ctttagagcg tcaggcctgg gatcggctct tactgcagta ccagaacgag
841 gttccacctg aagagatgcc cagaggatca actgaaacca aaatcaatga agtgaatgtg
901 gacccggcag cctacctcag gtcttcccag aaggaagttc tgaacacgaa acccgactat
961 cagagaatag tgcagagtca gaatgaagtc tttgcctata tggaattagt gatggatgag
1021 ctacaaggag cagtgaagca gctgcaagcc ttcatggatg aaagtactca gtacctccag
1081 aaggtgtcag tacagctcaa gaagagaagt atggagcagt tagattcttc acctgctcga
1141 aaactgctca agctccatct acagagctca tctaccaccc agtgatcagg atcctgtcag
1201 ggatcttacc tcacagcact cagctgggaa gtcctggccc tgcagcactt tcactgttcc
1261 tgagtgactg catatctgta tccagaagag agtgttaagg acacttttgt aatagtgtgc
1321 aagatgctta aaatgacctt cagaaccatt gctctaaata tcttcatggt cagcgctttt
1381 catcccataa aacgatccaa agacatctag aactaacctt aaggcaatgt tttaggggcc
1441 acggtagatt gtcggcataa aagactgatg ctaaagtttg agtgtgggac taaaggcaga
1501 ttataggagg ttgtcacata acgggtgtgc gtggacactt ttaaaatgtc cattttctga
1561 agtgtcctaa tgtctgtaga gtgctttagt ttttaatatt gaattgaatt cctttgggaa
1621 ttcccctgcc tccctaagaa ttgagcccag ggctttgtga gtactaggga aacactctca
1681 tgaagctgca tcttcagtcc ccatggtttt tgtcttttta agttctagtt cctgagtggc
1741 acctggacca taatagccct gtgagctgta ttttaaaaac catgtgttgt catttcctgt
1801 gactgagata tagtcacttg acctcttatc tagaacatta gaagggtgtt agaagctatg
1861 ctgtaaggac actgtaagga ttcgtttaaa gagtaaaagc ctagaacaat gttgttgaag
1921 atttaaaaat gagtagacag tagttaatga ggtgaaaaag ctaatatcta atttggaata
1981 ccacatggag agctcaagca gatacatata aagtctggat tagaaataaa tttaagttat
2041 gtctagctgt tggagtgatg tttttgtaca ttatgtgaca gtgtgtctct gcctttccct
2101 gccttcctaa agcaccttct gattggttaa aataaaaagc ctctggccta cagcaaaagg
2161 caggatagta aagtagaaca tccagaaaga ggaactggga agaagtcagg cgcatgagat
2221 ttgccaccca aagtgggatg tatgaaactg aggcaaggta accagccgtt cagcagacat
2281 ggaatagtat aagtgggcta atataagtta agagccagtt ggtgaactag agccagttgg
2341 ggaactagcc taagccaagg ccaaaagcat tataagtata gcttctttgg gaaagcatca
2401 aatgctagat gtcgccagtg cagatggagg accaagggct caggattagg aatctgcagc
2461 agcttctgtg gaggatacag cagtggttgt ggtcgaggcc ttgaggacca tggaggtaaa
2521 gttgaagaca aggagtagat ccccatcacc aagctgggcc gccttgaaga tcaagtcctt
2581 gaaagagatc tacctgttct ccctgcccat taaggaatct gattattgac tttcctgggc
2641 acatccctaa aggatgaggt ctgaagatcc tgccgggaca gaagcagcat ccactggtca
2701 gcagaccgac ttaaggcttt tgtggctact ggggactaca gtggtcacat tggttttggt
2761 gttaagtgct ctccaaggag gtacccactg ccatctgagg ggccatcatt ttgtccaaga
2821 tcccatcatc atccctgtgc agagagggta cgggggaaca agattgacaa gccccacact
2881 gttccatgca aggtgacagg ctgctgtgac tctgtacatc tcatccctgc ccccagaggc
2941 actggcattg cctgttcagt gctgaaaagg ctactgatga tggccggtat agatgactgc
3001 tacacatcag ccaggggctg cactgccacc ctggacaact ttgccaaggc cacctttgat
3061 gccacctcca agacctacag ctacctgacc cccaacctct ggaaagagac tgatccttat
3121 ctggaaagaa caagtttcct tatcagggat ttcactgatc atcttgtgaa aactcacacc
3181 agagtctttg ttcagagaac ccaggctcca gttgtggcta caacctaagg ctttttatac
3241 aagaaaaata aagtgaatta agtctgataa taaataaata aataaataaa taaataaata
3301 aa
//