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Rattus norvegicus DSN1 component of MIS12 kinetochore complex (Dsn1), transcript variant 3, mRNA

NCBI Reference Sequence: NM_001428684.1

FASTA Graphics 

LOCUS       NM_001428684            3302 bp    mRNA    linear   ROD 20-MAR-2024
DEFINITION  Rattus norvegicus DSN1 component of MIS12 kinetochore complex
            (Dsn1), transcript variant 3, mRNA.
ACCESSION   NM_001428684
VERSION     NM_001428684.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Sun,C., Huang,S., Ju,W., Hou,Y., Wang,Z., Liu,Y., Wu,L. and He,X.
  TITLE     Elevated DSN1 expression is associated with poor survival in
            patients with hepatocellular carcinoma
  JOURNAL   Hum Pathol 81, 113-120 (2018)
   PUBMED   30136646
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Chuang,T.P., Wang,J.Y., Jao,S.W., Wu,C.C., Chen,J.H., Hsiao,K.H.,
            Lin,C.Y., Chen,S.H., Su,S.Y., Chen,Y.J., Chen,Y.T., Wu,D.C. and
            Li,L.H.
  TITLE     Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal
            adenoma to carcinoma progression
  JOURNAL   Oncotarget 7 (29), 45803-45818 (2016)
   PUBMED   27329586
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Kline,S.L., Cheeseman,I.M., Hori,T., Fukagawa,T. and Desai,A.
  TITLE     The human Mis12 complex is required for kinetochore assembly and
            proper chromosome segregation
  JOURNAL   J Cell Biol 173 (1), 9-17 (2006)
   PUBMED   16585270
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Cheeseman,I.M., Niessen,S., Anderson,S., Hyndman,F., Yates,J.R.
            3rd, Oegema,K. and Desai,A.
  TITLE     A conserved protein network controls assembly of the outer
            kinetochore and its ability to sustain tension
  JOURNAL   Genes Dev 18 (18), 2255-2268 (2004)
   PUBMED   15371340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1786144.1,
                                           SRR26360172.1027099.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000003.1  166085824-166085920 c
            98-123              JAXUCZ010000003.1  166084679-166084704 c
            124-487             JAXUCZ010000003.1  166084041-166084404 c
            488-561             JAXUCZ010000003.1  166081950-166082023 c
            562-634             JAXUCZ010000003.1  166080949-166081021 c
            635-725             JAXUCZ010000003.1  166079777-166079867 c
            726-785             JAXUCZ010000003.1  166077939-166077998 c
            786-863             JAXUCZ010000003.1  166077479-166077556 c
            864-1011            JAXUCZ010000003.1  166076275-166076422 c
            1012-1099           JAXUCZ010000003.1  166075407-166075494 c
            1100-3302           JAXUCZ010000003.1  166072775-166074977 c
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..3302
                     /gene="Dsn1"
                     /note="DSN1 component of MIS12 kinetochore complex"
                     /db_xref="GeneID:499933"
                     /db_xref="RGD:1565179"
     exon            1..97
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..123
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            124..487
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    151..153
                     /gene="Dsn1"
                     /note="upstream in-frame stop codon"
     CDS             157..1185
                     /gene="Dsn1"
                     /note="isoform 2 is encoded by transcript variant 3;
                     kinetochore-associated protein DSN1 homolog; DSN1, MIND
                     kinetochore complex component, homolog; DSN1, MIS12
                     kinetochore complex component; DSN1 homolog, MIS12
                     kinetochore complex component"
                     /codon_start=1
                     /product="kinetochore-associated protein DSN1 homolog
                     isoform 2"
                     /protein_id="NP_001415613.1"
                     /db_xref="GeneID:499933"
                     /db_xref="RGD:1565179"
                     /translation="MLDQGPTMSETQDRPLQPSLEPLEALPRSSAYQEMMAQGTSEEQ
                     NHLGRSPREGEGCGADPQEGPQLRSFHLSPQEQSARHRDRRQSWRRASMKEINRRKSL
                     APFHPGITELSRSISMKLAQSQRLGALLLSSFQFSVEKLEPFLKNTKDFSLECFRAKA
                     SSLSEELKHFTDRLGNDGTLQKCFVEDSKEKAPDFSLEASVAEVKEYITKFSLERQAW
                     DRLLLQYQNEVPPEEMPRGSTETKINEVNVDPAAYLRSSQKEVLNTKPDYQRIVQSQN
                     EVFAYMELVMDELQGAVKQLQAFMDESTQYLQKVSVQLKKRSMEQLDSSPARKLLKLH
                     LQSSSTTQ"
     exon            488..561
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..634
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..725
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..785
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..863
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1011
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1099
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..3302
                     /gene="Dsn1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcggcggg agtttcggaa gtagctgcgg cagcgcggaa cctggaacta gactaacggg
       61 gaagaccacc ctctgtggtg acgcccagtc tgcagaggat gacttcggtg accaaatcag
      121 aaggctcgat tttatatttt gacttttctg tgacaaatgc tagaccaggg accaacgatg
      181 tcggagactc aggatcgtcc attgcaacca agtctcgagc ctttggaagc attgcctcga
      241 tcctctgcct accaggaaat gatggcacaa ggcacttcag aggaacaaaa ccaccttggc
      301 cggagcccca gagaggggga aggttgtggt gctgaccccc aggagggacc tcagttgagg
      361 tcctttcatt tgtctcctca agaacagtct gcccgtcaca gagacagaag gcagtcctgg
      421 aggcgagcaa gcatgaaaga gataaaccgg cggaagtcgt tggctccttt tcacccgggc
      481 atcacagagc tcagcaggtc aatcagtatg aagttagcac agagccaacg gcttggcgcc
      541 ctcctgctct ccagcttcca gttctctgtt gaaaaacttg aacctttctt aaagaacact
      601 aaggacttca gccttgaatg ttttagagcc aaagcatctt ctctctctga agaattgaaa
      661 cattttacag acaggctggg aaatgatgga actctacaaa aatgttttgt tgaagattca
      721 aaagaaaaag caccagattt ctcactggaa gcatcagtag ctgaggtgaa agaatatata
      781 acaaagtttt ctttagagcg tcaggcctgg gatcggctct tactgcagta ccagaacgag
      841 gttccacctg aagagatgcc cagaggatca actgaaacca aaatcaatga agtgaatgtg
      901 gacccggcag cctacctcag gtcttcccag aaggaagttc tgaacacgaa acccgactat
      961 cagagaatag tgcagagtca gaatgaagtc tttgcctata tggaattagt gatggatgag
     1021 ctacaaggag cagtgaagca gctgcaagcc ttcatggatg aaagtactca gtacctccag
     1081 aaggtgtcag tacagctcaa gaagagaagt atggagcagt tagattcttc acctgctcga
     1141 aaactgctca agctccatct acagagctca tctaccaccc agtgatcagg atcctgtcag
     1201 ggatcttacc tcacagcact cagctgggaa gtcctggccc tgcagcactt tcactgttcc
     1261 tgagtgactg catatctgta tccagaagag agtgttaagg acacttttgt aatagtgtgc
     1321 aagatgctta aaatgacctt cagaaccatt gctctaaata tcttcatggt cagcgctttt
     1381 catcccataa aacgatccaa agacatctag aactaacctt aaggcaatgt tttaggggcc
     1441 acggtagatt gtcggcataa aagactgatg ctaaagtttg agtgtgggac taaaggcaga
     1501 ttataggagg ttgtcacata acgggtgtgc gtggacactt ttaaaatgtc cattttctga
     1561 agtgtcctaa tgtctgtaga gtgctttagt ttttaatatt gaattgaatt cctttgggaa
     1621 ttcccctgcc tccctaagaa ttgagcccag ggctttgtga gtactaggga aacactctca
     1681 tgaagctgca tcttcagtcc ccatggtttt tgtcttttta agttctagtt cctgagtggc
     1741 acctggacca taatagccct gtgagctgta ttttaaaaac catgtgttgt catttcctgt
     1801 gactgagata tagtcacttg acctcttatc tagaacatta gaagggtgtt agaagctatg
     1861 ctgtaaggac actgtaagga ttcgtttaaa gagtaaaagc ctagaacaat gttgttgaag
     1921 atttaaaaat gagtagacag tagttaatga ggtgaaaaag ctaatatcta atttggaata
     1981 ccacatggag agctcaagca gatacatata aagtctggat tagaaataaa tttaagttat
     2041 gtctagctgt tggagtgatg tttttgtaca ttatgtgaca gtgtgtctct gcctttccct
     2101 gccttcctaa agcaccttct gattggttaa aataaaaagc ctctggccta cagcaaaagg
     2161 caggatagta aagtagaaca tccagaaaga ggaactggga agaagtcagg cgcatgagat
     2221 ttgccaccca aagtgggatg tatgaaactg aggcaaggta accagccgtt cagcagacat
     2281 ggaatagtat aagtgggcta atataagtta agagccagtt ggtgaactag agccagttgg
     2341 ggaactagcc taagccaagg ccaaaagcat tataagtata gcttctttgg gaaagcatca
     2401 aatgctagat gtcgccagtg cagatggagg accaagggct caggattagg aatctgcagc
     2461 agcttctgtg gaggatacag cagtggttgt ggtcgaggcc ttgaggacca tggaggtaaa
     2521 gttgaagaca aggagtagat ccccatcacc aagctgggcc gccttgaaga tcaagtcctt
     2581 gaaagagatc tacctgttct ccctgcccat taaggaatct gattattgac tttcctgggc
     2641 acatccctaa aggatgaggt ctgaagatcc tgccgggaca gaagcagcat ccactggtca
     2701 gcagaccgac ttaaggcttt tgtggctact ggggactaca gtggtcacat tggttttggt
     2761 gttaagtgct ctccaaggag gtacccactg ccatctgagg ggccatcatt ttgtccaaga
     2821 tcccatcatc atccctgtgc agagagggta cgggggaaca agattgacaa gccccacact
     2881 gttccatgca aggtgacagg ctgctgtgac tctgtacatc tcatccctgc ccccagaggc
     2941 actggcattg cctgttcagt gctgaaaagg ctactgatga tggccggtat agatgactgc
     3001 tacacatcag ccaggggctg cactgccacc ctggacaact ttgccaaggc cacctttgat
     3061 gccacctcca agacctacag ctacctgacc cccaacctct ggaaagagac tgatccttat
     3121 ctggaaagaa caagtttcct tatcagggat ttcactgatc atcttgtgaa aactcacacc
     3181 agagtctttg ttcagagaac ccaggctcca gttgtggcta caacctaagg ctttttatac
     3241 aagaaaaata aagtgaatta agtctgataa taaataaata aataaataaa taaataaata
     3301 aa
//
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