LOCUS NM_017009 2714 bp mRNA linear ROD 03-APR-2024
DEFINITION Rattus norvegicus glial fibrillary acidic protein (Gfap), mRNA.
ACCESSION NM_017009 XM_346410
VERSION NM_017009.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2714)
AUTHORS Dandi,Epsilon., Theotokis,P., Petri,M.C., Sideropoulou,V.,
Spandou,E. and Tata,D.A.
TITLE Environmental enrichment initiated in adolescence restores the
reduced expression of synaptophysin and GFAP in the hippocampus of
chronically stressed rats in a sex-specific manner
JOURNAL Dev Psychobiol 65 (7), e22422 (2023)
PUBMED 37796476
REMARK GeneRIF: Environmental enrichment initiated in adolescence restores
the reduced expression of synaptophysin and GFAP in the hippocampus
of chronically stressed rats in a sex-specific manner.
REFERENCE 2 (bases 1 to 2714)
AUTHORS Gok,E. and Deveci,E.
TITLE Histopathological evaluation of IBA-1, GFAP activity in the brain
cortex of rats administered cadmium chloride
JOURNAL Arch Ital Biol 160 (1-2), 20-27 (2022)
PUBMED 35913387
REMARK GeneRIF: Histopathological evaluation of IBA-1, GFAP activity in
the brain cortex of rats administered cadmium chloride.
REFERENCE 3 (bases 1 to 2714)
AUTHORS Aamodt,A.H., Hogestol,E.A., Popperud,T.H., Holter,J.C.,
Dyrhol-Riise,A.M., Tonby,K., Stiksrud,B., Quist-Paulsen,E.,
Berge,T., Barratt-Due,A., Aukrust,P., Heggelund,L., Blennow,K.,
Zetterberg,H. and Harbo,H.F.
TITLE Blood neurofilament light concentration at admittance: a potential
prognostic marker in COVID-19
JOURNAL J Neurol 268 (10), 3574-3583 (2021)
PUBMED 33743046
REFERENCE 4 (bases 1 to 2714)
AUTHORS Othman,H., Lopez-Furelos,A., Leiro-Vidal,J.M., Ammari,M., Sakly,M.,
Abdelmelek,H., Salas-Sanchez,A.A., Ares-Pena,F. and Lopez-Martin,E.
TITLE Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70,
Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain
JOURNAL Int J Mol Sci 22 (10), 5103 (2021)
PUBMED 34065959
REMARK GeneRIF: Exposure to 2.45 GHz Radiation Triggers Changes in HSP-70,
Glucocorticoid Receptors and GFAP Biomarkers in Rat Brain.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2714)
AUTHORS Tsyba,D.L., Kirik,O.V., Kolpakova,M.E., Yakovleva,A.A. and
Korzhevskii,D.E.
TITLE Expression of Nestin and Glial Fibrillary Acidic Protein in the
Marginal Ischemic Zone of the Brain in SHR Rats
JOURNAL Bull Exp Biol Med 169 (4), 576-581 (2020)
PUBMED 32910393
REMARK GeneRIF: Expression of Nestin and Glial Fibrillary Acidic Protein
in the Marginal Ischemic Zone of the Brain in SHR Rats.
REFERENCE 6 (bases 1 to 2714)
AUTHORS McCall,M.A., Gregg,R.G., Behringer,R.R., Brenner,M., Delaney,C.L.,
Galbreath,E.J., Zhang,C.L., Pearce,R.A., Chiu,S.Y. and Messing,A.
TITLE Targeted deletion in astrocyte intermediate filament (Gfap) alters
neuronal physiology
JOURNAL Proc Natl Acad Sci U S A 93 (13), 6361-6366 (1996)
PUBMED 8692820
REFERENCE 7 (bases 1 to 2714)
AUTHORS Molthagen,M., Schachner,M. and Bartsch,U.
TITLE Apoptotic cell death of photoreceptor cells in mice deficient for
the adhesion molecule on glia (AMOG, the beta 2- subunit of the Na,
K-ATPase)
JOURNAL J Neurocytol 25 (4), 243-255 (1996)
PUBMED 8793730
REFERENCE 8 (bases 1 to 2714)
AUTHORS Condorelli,D.F., Nicoletti,V.G., Barresi,V., Caruso,A.,
Conticello,S., de Vellis,J. and Giuffrida Stella,A.M.
TITLE Tissue-specific DNA methylation patterns of the rat glial
fibrillary acidic protein gene
JOURNAL J Neurosci Res 39 (6), 694-707 (1994)
PUBMED 7897704
REFERENCE 9 (bases 1 to 2714)
AUTHORS Feinstein,D.L., Weinmaster,G.A. and Milner,R.J.
TITLE Isolation of cDNA clones encoding rat glial fibrillary acidic
protein: expression in astrocytes and in Schwann cells
JOURNAL J Neurosci Res 32 (1), 1-14 (1992)
PUBMED 1629938
REFERENCE 10 (bases 1 to 2714)
AUTHORS Nichols,N.R., Osterburg,H.H., Masters,J.N., Millar,S.L. and
Finch,C.E.
TITLE Messenger RNA for glial fibrillary acidic protein is decreased in
rat brain following acute and chronic corticosterone treatment
JOURNAL Brain Res Mol Brain Res 7 (1), 1-7 (1990)
PUBMED 2153890
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC088851.1.
On Oct 12, 2007 this sequence version replaced NM_017009.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC088851.1, U03700.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760393, SAMEA5760433
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..2714
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="10"
/map="10q32.1"
gene 1..2714
/gene="Gfap"
/note="glial fibrillary acidic protein"
/db_xref="GeneID:24387"
/db_xref="RGD:2679"
exon 1..456
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
CDS 2..1294
/gene="Gfap"
/note="intermediate filament; glial fibrillary acidic
protein alpha; glial fibrillary acidic protein delta"
/codon_start=1
/product="glial fibrillary acidic protein"
/protein_id="NP_058705.2"
/db_xref="GeneID:24387"
/db_xref="RGD:2679"
/translation="MERRRITSARRSYASSETMVRGHGPTRHLGTIPRLSLSRMTPPL
PARVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQL
RAKEPTKLADVYQAELRELRLRLDQLTTNSARLEVERDNLTQDLGTLRQKLQDETNLR
LEAENNLAVYRQEADEATLARVDLERKVESLEEEIQFLRKIHEEEVRELQEQLAQQQV
HVEMDVAKPDLTAALREIRTQYEAVATSNMQETEEWYRSKFADLTDVASRNAELLRQA
KHEANDYRRQLQALTCDLESLRGTNESLERQMREQEERHARESASYQEALARLEEEGQ
SLKEEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSL
DTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM"
misc_feature 2..211
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Head"
misc_feature 2..94
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 20..22
/gene="Gfap"
/note="Phosphothreonine, by AURKB and ROCK1.
/evidence=ECO:0000250|UniProtKB:P14136; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 32..34
/gene="Gfap"
/note="Omega-N-methylarginine.
/evidence=ECO:0000250|UniProtKB:P03995; propagated from
UniProtKB/Swiss-Prot (P47819.2); methylation site"
misc_feature 35..37
/gene="Gfap"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 62..64
/gene="Gfap"
/note="Omega-N-methylarginine.
/evidence=ECO:0000250|UniProtKB:P03995; propagated from
UniProtKB/Swiss-Prot (P47819.2); methylation site"
misc_feature 107..109
/gene="Gfap"
/note="Phosphoserine, by AURKB and ROCK1.
/evidence=ECO:0000250|UniProtKB:P14136; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 122..124
/gene="Gfap"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P03995; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 212..307
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Coil 1A"
misc_feature 239..241
/gene="Gfap"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 308..340
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Linker 1"
misc_feature 323..325
/gene="Gfap"
/note="Phosphothreonine. /evidence=ECO:0000269|Ref.9;
propagated from UniProtKB/Swiss-Prot (P47819.2);
phosphorylation site"
misc_feature 341..637
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Coil 1B"
misc_feature 443..445
/gene="Gfap"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 638..685
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Linker 12"
misc_feature 686..751
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Coil 2A"
misc_feature 752..763
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Linker 2"
misc_feature 764..1126
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Coil 2B"
misc_feature 800..802
/gene="Gfap"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 962..964
/gene="Gfap"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
misc_feature 1127..1291
/gene="Gfap"
/note="propagated from UniProtKB/Swiss-Prot (P47819.2);
Region: Tail"
misc_feature 1142..1144
/gene="Gfap"
/note="Phosphothreonine. /evidence=ECO:0000269|Ref.9;
propagated from UniProtKB/Swiss-Prot (P47819.2);
phosphorylation site"
misc_feature 1148..1150
/gene="Gfap"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P47819.2); phosphorylation site"
exon 457..517
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 518..613
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 614..775
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 776..901
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 902..1122
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 1123..1166
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 1167..1252
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
exon 1253..2688
/gene="Gfap"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 gatggagcgg agacgtatca cctctgcacg ccgctcctat gcctcctccg agacgatggt
61 caggggccat ggtcctacca gacacctggg taccattccg cgcctctccc tgtctcgaat
121 gacgcctcca ctccctgcca gggtagactt ctccctggcc ggggcgctca atgccggctt
181 caaagagact cgggccagcg agcgtgcgga gatgatggag ctcaatgacc gctttgctag
241 ctacatcgag aaggtccgct tcctggaaca gcaaaacaag gcgctggcag ctgagctgaa
301 ccagcttcga gccaaggagc ccaccaaact ggctgacgtt taccaggcag aacttcggga
361 gctgcggctg cgtctggacc agcttactac caacagtgcc cggctggagg tggagaggga
421 caatctcaca caggacctcg gcaccctgag gcagaagctc caagatgaaa ccaacctgag
481 gctggaggcg gagaacaacc tggctgtgta cagacaggag gcggatgaag ccaccttggc
541 tcgtgtggat ctggagagga aggttgagtc gctggaggag gagatccagt tcttgaggaa
601 gatccatgag gaggaagttc gagaactcca ggagcagctg gcccagcagc aggtccacgt
661 ggagatggat gtggccaagc cagacctcac agcggctctg agagagattc gcactcagta
721 cgaggcagtg gccaccagta acatgcaaga aacagaagag tggtatcggt ccaagtttgc
781 agacctcaca gacgttgctt cccgcaacgc agagctgctc cgccaggcca agcacgaggc
841 taatgactat cgccgccaac tgcaggcctt gacctgcgac cttgagtcct tgcgcggcac
901 gaacgagtcc ttggagaggc aaatgcgcga acaggaggag cgccacgcgc gggagtcggc
961 gagttaccag gaggcactcg ctcggctgga ggaggagggc caaagcctca aggaggagat
1021 ggcccgccac ctgcaggagt accaggatct actcaacgtt aagctagccc tggacatcga
1081 gatcgccacc tacaggaaat tgctggaggg cgaagaaaac cgcatcacca ttcctgtaca
1141 gactttctcc aacctccaga tccgagaaac cagcctggac accaaatctg tgtcagaagg
1201 ccacctcaag aggaacatcg tggtaaagac ggtggagatg cgggatggcg aggtcattaa
1261 ggagtcgaag caggagcaca aggatgtgat gtgaggtgtg cccagctggc agcccttgcc
1321 atacagtgtg agggcctaaa gctccctcct cagatagtct tgtttgctag gcccaattcc
1381 catccacacc agtgctcccc ttccttctgt ttttatgccc acggctcggt cagtgcggag
1441 tctcatggac ggcacagacc accctgcatc tccaactaac aggatactca ccccaaaggg
1501 gcaatcagga ggggaggacc cccctccccc cagctgggtt agaactggaa gaaagaggaa
1561 agacaggggc agggagactt aacaaatccc ttccttcatc cttgttgtta tggaaaccgt
1621 tgccagagct ggaggtctct gggaactgga ctttgagttt tcataggctg ctggagcaag
1681 acaaacattc agacagaaag gaaaagatcc cgaggcaaag aatctctagc cagaggccta
1741 ggcatctgga agaaccctga cgatgtagga gtgggtaggg cagacttgct acctggaatg
1801 gccactaagg cagtcctgaa gggcccccct ccggagggat gaccctcgtg tatcggcccc
1861 actgagcagc cctgcaggtt gatgccccac gagcgtgtga aaacttggtt cttggcatgt
1921 ggcaggctct atagcataag tggagaggga aggtgtactg gagggtatag aggagggctc
1981 tctggcccct aagtatggat gcggagaggg gggagcccag gaaggctacc ccgctcaggc
2041 tgcaggggtg ccatggcgga ggaaccggtg gagataactt ggacaatgga gttggaagtt
2101 gtaggcaact agttacactt ggctctgaat ccttggaatc aaggaaatga cctgttctct
2161 caaagacact gaaacaggag agagggactt ccatccactg ggcagggtac aggcgcgtct
2221 cagttgtgaa ggtctattcc tggttgctca gtccccaact gcgcatcacc ctgggcttct
2281 caacctggaa gagtccacaa ccatccttct gaggccctcc atccccacaa ccactagctg
2341 ttgttctcca agccaagggc cccattccct ttcttatgca tgtacggagt atcgcctaga
2401 ctttaagcgt ccatcctgtt tgaaagtttg ggaaactgac acacgttgtg ttcaagcagc
2461 ctggtgtgga gtgccttcgt attagtgtac cctctcggaa gctggttggt gggcaggtga
2521 ggaagaaatg gagctgaaag tgtcccctca gttgtccttt cctccccctc taaggtccct
2581 cccttttccc aggacatcgt acactccccc ccttgtcacc tctgctaacc ttcagagcag
2641 tactgtcacc tttactcact gggcagaaat aaagacagtg tcagaggcaa aaaaaaaaaa
2701 aaaaaaaaaa aaaa
//