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Rattus norvegicus phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase (Paics), transcript variant 1, mRNA

NCBI Reference Sequence: NM_080910.4

FASTA Graphics 

LOCUS       NM_080910               1971 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus phosphoribosylaminoimidazole carboxylase and
            phosphoribosylaminoimidazolesuccinocarboxamide synthase (Paics),
            transcript variant 1, mRNA.
ACCESSION   NM_080910
VERSION     NM_080910.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Ikeda,M., Tomita,Y., Mouri,A., Koga,M., Okochi,T., Yoshimura,R.,
            Yamanouchi,Y., Kinoshita,Y., Hashimoto,R., Williams,H.J.,
            Takeda,M., Nakamura,J., Nabeshima,T., Owen,M.J., O'Donovan,M.C.,
            Honda,H., Arinami,T., Ozaki,N. and Iwata,N.
  TITLE     Identification of novel candidate genes for treatment response to
            risperidone and susceptibility for schizophrenia: integrated
            analysis among pharmacogenomics, mouse expression, and genetic
            case-control association approaches
  JOURNAL   Biol Psychiatry 67 (3), 263-269 (2010)
   PUBMED   19850283
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 1971)
  AUTHORS   Iwahana,H., Honda,S., Tsujisawa,T., Takahashi,Y., Adzuma,K.,
            Katashima,R., Yamaoka,T., Moritani,M., Yoshimoto,K. and Itakura,M.
  TITLE     Rat genomic structure of amidophosphoribosyltransferase, cDNA
            sequence of aminoimidazole ribonucleotide carboxylase, and cell
            cycle-dependent expression of these two physically linked genes
  JOURNAL   Biochim Biophys Acta 1261 (3), 369-380 (1995)
   PUBMED   7742366
REFERENCE   8  (bases 1 to 1971)
  AUTHORS   Ichihara,Y., Sogawa,K., Morohashi,K., Fujii-Kuriyama,Y. and
            Takahashi,K.
  TITLE     Nucleotide sequence of a nearly full-length cDNA coding for
            pepsinogen of rat gastric mucosa
  JOURNAL   Eur J Biochem 161 (1), 7-12 (1986)
   PUBMED   3780741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Oct 16, 2024 this sequence version replaced NM_080910.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085711.1, SRR26643286.38550.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000014.1  31569992-31570033   c
            43-109              JAXUCZ010000014.1  31569819-31569885   c
            110-307             JAXUCZ010000014.1  31565795-31565992   c
            308-486             JAXUCZ010000014.1  31561385-31561563   c
            487-666             JAXUCZ010000014.1  31559493-31559672   c
            667-780             JAXUCZ010000014.1  31559154-31559267   c
            781-864             JAXUCZ010000014.1  31558751-31558834   c
            865-1045            JAXUCZ010000014.1  31556806-31556986   c
            1046-1204           JAXUCZ010000014.1  31554353-31554511   c
            1205-1971           JAXUCZ010000014.1  31553348-31554114   c
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p11"
     gene            1..1971
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="phosphoribosylaminoimidazole carboxylase and
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /db_xref="GeneID:140946"
                     /db_xref="RGD:620066"
     exon            1..42
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            43..109
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1371
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /EC_number="6.3.2.6"
                     /EC_number="4.1.1.21"
                     /note="multifunctional protein ADE2;
                     phosphoribosylaminoimidazole carboxylase,
                     phosphoribosylaminoribosylaminoimidazole
                     succinocarboxamide synthetase; multifunctional protein
                     ADE2-like; phosphoribosylaminoimidazole carboxylase,
                     phosphoribosylaminoimidazole succinocarboxamide
                     synthetase; AIR carboxylase-SAICAR synthetase;
                     phosphoribosylaminoimidazole carboxylase;
                     phosphoribosylaminoimidazolesuccinocarboxamide synthase"
                     /codon_start=1
                     /product="bifunctional phosphoribosylaminoimidazole
                     carboxylase/phosphoribosylaminoimidazole
                     succinocarboxamide synthetase"
                     /protein_id="NP_543186.1"
                     /db_xref="GeneID:140946"
                     /db_xref="RGD:620066"
                     /translation="MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNA
                     ARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRR
                     IATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQT
                     EVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWP
                     SGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTS
                     DLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNG
                     LGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFG
                     LNNHLVWAKLRASKLNTWISLKQADKKIRECNL"
     misc_feature    97..873
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="propagated from UniProtKB/Swiss-Prot (P51583.3);
                     Region: SAICAR synthetase domain.
                     /evidence=ECO:0000250|UniProtKB:P22234"
     misc_feature    97..99
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P22234; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); acetylation site"
     misc_feature    157..159
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9DCL9; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
     misc_feature    172..174
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
     misc_feature    199..201
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9DCL9; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); acetylation site"
     misc_feature    412..414
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22234; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
     misc_feature    805..807
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P22234; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
     misc_feature    832..834
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P22234; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); acetylation site"
     misc_feature    874..891
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="propagated from UniProtKB/Swiss-Prot (P51583.3);
                     Region: Linker. /evidence=ECO:0000250|UniProtKB:P22234"
     misc_feature    892..1368
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="propagated from UniProtKB/Swiss-Prot (P51583.3);
                     Region: AIR carboxylase domain.
                     /evidence=ECO:0000250|UniProtKB:P22234"
     misc_feature    913..915
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P22234; propagated from
                     UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
     exon            110..307
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            308..486
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            487..666
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            667..780
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            781..864
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1045
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1204
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1971
                     /gene="Paics"
                     /gene_synonym="Ade2h1; Airc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcctgccc tgagcagcca gccgagtgct ttgggttcgc tgatcgctgc ttctttttcc
       61 cgcgcggtct gctcctctag ttcacctagg ataatggcga cagctgaagt actgaacatc
      121 gggagaaagc tgtatgaggg taaaacaaag gaagtctatg aattgttaga cagtccagga
      181 agagtcctcc tgcagtccaa ggaccagatt acagcaggaa atgcagctag aaagaaccac
      241 ctggaaggca aagccgccat ctccaataag atcaccagct gcatatttca gttgttacag
      301 gaagctggta taaaaactgc tttcaccaag aaatgtgggg agactgcttt cattgcaccc
      361 cagtgtgaaa tgattccaat tgagtgggta tgccgaagaa tcgccactgg atcttttctc
      421 aaaaggaacc ctggtgtgaa ggaggggtat aggttttatc caccaaaagt agagatgttc
      481 ttcaaggatg atgccaataa cgacccacaa tggtctgagg agcaactcat cgctgcaaaa
      541 ttttgttttg ctggactcgt tatagggcaa actgaagtgg atatcatgag tcatgccaca
      601 caagctattt ttgaaattct ggagaaatcc tggctgcccc aaaactgtac gctggttgat
      661 atgaagattg agtttggcgt tgatgtaacc accaaagaga ttgttcttgc tgatgtcata
      721 gataatgatt cctggagact atggccatca ggagatcgga gccagcagaa agacaaacag
      781 tcttatcggg atctcaaaga agtaactccg gaaggactcc agatggtaaa gaagaacttt
      841 gagtgggttg cagaccgagt ggagttgctt ctcaagtcaa acagtcagtg cagggtggta
      901 gtgctgatgg ggtcgacctc tgaccttggt cactgtgaaa aaattaagaa ggcttgtgga
      961 aactttggga ttccatgtga acttagagta acatctgcac ataaaggacc agatgaaact
     1021 ttgaggatta aagcagaata tgaaggggat ggcataccta ctgtatttgt cgcagtggcg
     1081 ggcaggagca atggactggg cccagtgatg tctggtaata ctgcataccc ggttatcagc
     1141 tgtcccccaa tcacagcaga ctggggtgct caggatgtgt ggtcatctct gcgactgccc
     1201 agtggtattg gctgttcaac tatactttct ccagaaggat cagcccagtt tgctgctcag
     1261 atatttgggt taaacaacca tttggtgtgg gccaaacttc gagcgagcaa actgaacacg
     1321 tggatatcct taaagcaggc tgataagaaa atcagagagt gcaatttgta ataaagcaat
     1381 ttaatttgta ggagaaaagt tacatattcc tagtttggat ttaaaaaaaa aatcaagcaa
     1441 aatgatttca catcagagaa aacaattcag tttattttct ggctctatgt agtgatatgt
     1501 ccctgtagcc tgagcactct agaggatcac taaattcaag gccagcctga attgtgtatt
     1561 gagaccctgt atttgctggg gaggggatct tggcacaacg ctgctaaatt acatctcgct
     1621 ttctatatag tcattgttgg gtaaatatgt aattatggaa ctggagcaat gtgtctgtgg
     1681 ttcaagaacc agtatggctc tcctgcagat gccctgagtt tggctcccag catccatgta
     1741 gactgcctca caataaataa cctttaaccc gggatctgac cccgtggctt ccttatgcac
     1801 ctgctctcag attctgttac attcctccac ccaacacaca caattttaaa aaataaacgt
     1861 tttcaaagag tattatttct aagtggtaat aacatttata aatcaatagt attgcttgac
     1921 atttggagtt gacactttaa aaattaaaat attgtgcgtg ttaataacgt g
//
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Reference sequence information

  • RefSeq alternative splicing
    See 7 reference mRNA sequence splice variants for the Paics gene.
  • RefSeq protein product
    See the reference protein sequence for bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (NP_543186.1).

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