LOCUS NM_080910 1971 bp mRNA linear ROD 24-OCT-2024
DEFINITION Rattus norvegicus phosphoribosylaminoimidazole carboxylase and
phosphoribosylaminoimidazolesuccinocarboxamide synthase (Paics),
transcript variant 1, mRNA.
ACCESSION NM_080910
VERSION NM_080910.4
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1971)
AUTHORS Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
Zaidel-Bar,R.
TITLE E-cadherin interactome complexity and robustness resolved by
quantitative proteomics
JOURNAL Sci Signal 7 (354), rs7 (2014)
PUBMED 25468996
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1971)
AUTHORS Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
TITLE Toward an understanding of the protein interaction network of the
human liver
JOURNAL Mol Syst Biol 7, 536 (2011)
PUBMED 21988832
REMARK Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
10.15252/msb.20178107. PMID: 29254952]
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 1971)
AUTHORS Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
and Stoorvogel,W.
TITLE MHC class II-associated proteins in B-cell exosomes and potential
functional implications for exosome biogenesis
JOURNAL Immunol Cell Biol 88 (8), 851-856 (2010)
PUBMED 20458337
REFERENCE 4 (bases 1 to 1971)
AUTHORS Ikeda,M., Tomita,Y., Mouri,A., Koga,M., Okochi,T., Yoshimura,R.,
Yamanouchi,Y., Kinoshita,Y., Hashimoto,R., Williams,H.J.,
Takeda,M., Nakamura,J., Nabeshima,T., Owen,M.J., O'Donovan,M.C.,
Honda,H., Arinami,T., Ozaki,N. and Iwata,N.
TITLE Identification of novel candidate genes for treatment response to
risperidone and susceptibility for schizophrenia: integrated
analysis among pharmacogenomics, mouse expression, and genetic
case-control association approaches
JOURNAL Biol Psychiatry 67 (3), 263-269 (2010)
PUBMED 19850283
REFERENCE 5 (bases 1 to 1971)
AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 6 (bases 1 to 1971)
AUTHORS Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
Birchmeier,W., Lehrach,H. and Wanker,E.E.
TITLE A human protein-protein interaction network: a resource for
annotating the proteome
JOURNAL Cell 122 (6), 957-968 (2005)
PUBMED 16169070
REFERENCE 7 (bases 1 to 1971)
AUTHORS Iwahana,H., Honda,S., Tsujisawa,T., Takahashi,Y., Adzuma,K.,
Katashima,R., Yamaoka,T., Moritani,M., Yoshimoto,K. and Itakura,M.
TITLE Rat genomic structure of amidophosphoribosyltransferase, cDNA
sequence of aminoimidazole ribonucleotide carboxylase, and cell
cycle-dependent expression of these two physically linked genes
JOURNAL Biochim Biophys Acta 1261 (3), 369-380 (1995)
PUBMED 7742366
REFERENCE 8 (bases 1 to 1971)
AUTHORS Ichihara,Y., Sogawa,K., Morohashi,K., Fujii-Kuriyama,Y. and
Takahashi,K.
TITLE Nucleotide sequence of a nearly full-length cDNA coding for
pepsinogen of rat gastric mucosa
JOURNAL Eur J Biochem 161 (1), 7-12 (1986)
PUBMED 3780741
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000014.1.
On Oct 16, 2024 this sequence version replaced NM_080910.3.
##Evidence-Data-START##
Transcript exon combination :: BC085711.1, SRR26643286.38550.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on manual assertion, conservation,
expression, longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-42 JAXUCZ010000014.1 31569992-31570033 c
43-109 JAXUCZ010000014.1 31569819-31569885 c
110-307 JAXUCZ010000014.1 31565795-31565992 c
308-486 JAXUCZ010000014.1 31561385-31561563 c
487-666 JAXUCZ010000014.1 31559493-31559672 c
667-780 JAXUCZ010000014.1 31559154-31559267 c
781-864 JAXUCZ010000014.1 31558751-31558834 c
865-1045 JAXUCZ010000014.1 31556806-31556986 c
1046-1204 JAXUCZ010000014.1 31554353-31554511 c
1205-1971 JAXUCZ010000014.1 31553348-31554114 c
FEATURES Location/Qualifiers
source 1..1971
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="14"
/map="14p11"
gene 1..1971
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="phosphoribosylaminoimidazole carboxylase and
phosphoribosylaminoimidazolesuccinocarboxamide synthase"
/db_xref="GeneID:140946"
/db_xref="RGD:620066"
exon 1..42
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 43..109
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
CDS 94..1371
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/EC_number="6.3.2.6"
/EC_number="4.1.1.21"
/note="multifunctional protein ADE2;
phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoribosylaminoimidazole
succinocarboxamide synthetase; multifunctional protein
ADE2-like; phosphoribosylaminoimidazole carboxylase,
phosphoribosylaminoimidazole succinocarboxamide
synthetase; AIR carboxylase-SAICAR synthetase;
phosphoribosylaminoimidazole carboxylase;
phosphoribosylaminoimidazolesuccinocarboxamide synthase"
/codon_start=1
/product="bifunctional phosphoribosylaminoimidazole
carboxylase/phosphoribosylaminoimidazole
succinocarboxamide synthetase"
/protein_id="NP_543186.1"
/db_xref="GeneID:140946"
/db_xref="RGD:620066"
/translation="MATAEVLNIGRKLYEGKTKEVYELLDSPGRVLLQSKDQITAGNA
ARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTKKCGETAFIAPQCEMIPIEWVCRR
IATGSFLKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQT
EVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWP
SGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVADRVELLLKSNSQCRVVVLMGSTS
DLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNG
LGPVMSGNTAYPVISCPPITADWGAQDVWSSLRLPSGIGCSTILSPEGSAQFAAQIFG
LNNHLVWAKLRASKLNTWISLKQADKKIRECNL"
misc_feature 97..873
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="propagated from UniProtKB/Swiss-Prot (P51583.3);
Region: SAICAR synthetase domain.
/evidence=ECO:0000250|UniProtKB:P22234"
misc_feature 97..99
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="N-acetylalanine.
/evidence=ECO:0000250|UniProtKB:P22234; propagated from
UniProtKB/Swiss-Prot (P51583.3); acetylation site"
misc_feature 157..159
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:Q9DCL9; propagated from
UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
misc_feature 172..174
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
misc_feature 199..201
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q9DCL9; propagated from
UniProtKB/Swiss-Prot (P51583.3); acetylation site"
misc_feature 412..414
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P22234; propagated from
UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
misc_feature 805..807
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P22234; propagated from
UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
misc_feature 832..834
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:P22234; propagated from
UniProtKB/Swiss-Prot (P51583.3); acetylation site"
misc_feature 874..891
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="propagated from UniProtKB/Swiss-Prot (P51583.3);
Region: Linker. /evidence=ECO:0000250|UniProtKB:P22234"
misc_feature 892..1368
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="propagated from UniProtKB/Swiss-Prot (P51583.3);
Region: AIR carboxylase domain.
/evidence=ECO:0000250|UniProtKB:P22234"
misc_feature 913..915
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P22234; propagated from
UniProtKB/Swiss-Prot (P51583.3); phosphorylation site"
exon 110..307
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 308..486
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 487..666
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 667..780
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 781..864
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 865..1045
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 1046..1204
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
exon 1205..1971
/gene="Paics"
/gene_synonym="Ade2h1; Airc"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 gttcctgccc tgagcagcca gccgagtgct ttgggttcgc tgatcgctgc ttctttttcc
61 cgcgcggtct gctcctctag ttcacctagg ataatggcga cagctgaagt actgaacatc
121 gggagaaagc tgtatgaggg taaaacaaag gaagtctatg aattgttaga cagtccagga
181 agagtcctcc tgcagtccaa ggaccagatt acagcaggaa atgcagctag aaagaaccac
241 ctggaaggca aagccgccat ctccaataag atcaccagct gcatatttca gttgttacag
301 gaagctggta taaaaactgc tttcaccaag aaatgtgggg agactgcttt cattgcaccc
361 cagtgtgaaa tgattccaat tgagtgggta tgccgaagaa tcgccactgg atcttttctc
421 aaaaggaacc ctggtgtgaa ggaggggtat aggttttatc caccaaaagt agagatgttc
481 ttcaaggatg atgccaataa cgacccacaa tggtctgagg agcaactcat cgctgcaaaa
541 ttttgttttg ctggactcgt tatagggcaa actgaagtgg atatcatgag tcatgccaca
601 caagctattt ttgaaattct ggagaaatcc tggctgcccc aaaactgtac gctggttgat
661 atgaagattg agtttggcgt tgatgtaacc accaaagaga ttgttcttgc tgatgtcata
721 gataatgatt cctggagact atggccatca ggagatcgga gccagcagaa agacaaacag
781 tcttatcggg atctcaaaga agtaactccg gaaggactcc agatggtaaa gaagaacttt
841 gagtgggttg cagaccgagt ggagttgctt ctcaagtcaa acagtcagtg cagggtggta
901 gtgctgatgg ggtcgacctc tgaccttggt cactgtgaaa aaattaagaa ggcttgtgga
961 aactttggga ttccatgtga acttagagta acatctgcac ataaaggacc agatgaaact
1021 ttgaggatta aagcagaata tgaaggggat ggcataccta ctgtatttgt cgcagtggcg
1081 ggcaggagca atggactggg cccagtgatg tctggtaata ctgcataccc ggttatcagc
1141 tgtcccccaa tcacagcaga ctggggtgct caggatgtgt ggtcatctct gcgactgccc
1201 agtggtattg gctgttcaac tatactttct ccagaaggat cagcccagtt tgctgctcag
1261 atatttgggt taaacaacca tttggtgtgg gccaaacttc gagcgagcaa actgaacacg
1321 tggatatcct taaagcaggc tgataagaaa atcagagagt gcaatttgta ataaagcaat
1381 ttaatttgta ggagaaaagt tacatattcc tagtttggat ttaaaaaaaa aatcaagcaa
1441 aatgatttca catcagagaa aacaattcag tttattttct ggctctatgt agtgatatgt
1501 ccctgtagcc tgagcactct agaggatcac taaattcaag gccagcctga attgtgtatt
1561 gagaccctgt atttgctggg gaggggatct tggcacaacg ctgctaaatt acatctcgct
1621 ttctatatag tcattgttgg gtaaatatgt aattatggaa ctggagcaat gtgtctgtgg
1681 ttcaagaacc agtatggctc tcctgcagat gccctgagtt tggctcccag catccatgta
1741 gactgcctca caataaataa cctttaaccc gggatctgac cccgtggctt ccttatgcac
1801 ctgctctcag attctgttac attcctccac ccaacacaca caattttaaa aaataaacgt
1861 tttcaaagag tattatttct aagtggtaat aacatttata aatcaatagt attgcttgac
1921 atttggagtt gacactttaa aaattaaaat attgtgcgtg ttaataacgt g
//