LOCUS NM_031235 5500 bp mRNA linear ROD 10-OCT-2020
DEFINITION Rattus norvegicus par-3 family cell polarity regulator (Pard3),
mRNA.
ACCESSION NM_031235
VERSION NM_031235.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 5500)
AUTHORS Jing Z, Jia-Jun W and Wei-Jie Y.
TITLE Phosphorylation of Dab2 is involved in inhibited VEGF-VEGFR-2
signaling induced by downregulation of syndecan-1 in glomerular
endothelial cell
JOURNAL Cell Biol Int 44 (3), 894-904 (2020)
PUBMED 31868265
REMARK GeneRIF: Phosphorylation of Dab2 is involved in inhibited
VEGF-VEGFR-2 signaling induced by downregulation of syndecan-1 in
glomerular endothelial cell.
REFERENCE 2 (bases 1 to 5500)
AUTHORS Sasaki K, Kakuwa T, Akimoto K, Koga H and Ohno S.
TITLE Regulation of epithelial cell polarity by PAR-3 depends on Girdin
transcription and Girdin-Galphai3 signaling
JOURNAL J Cell Sci 128 (13), 2244-2258 (2015)
PUBMED 25977476
REMARK GeneRIF: transcriptional upregulation of Girdin expression and
Girdin-Galphai3 signaling play crucial roles in regulating
epithelial apicobasal polarity through the PAR complex.
REFERENCE 3 (bases 1 to 5500)
AUTHORS Xu G, Wang R, Wang Z, Lei Q, Yu Z, Liu C, Li P, Yang Z, Cheng X, Li
G and Wu M.
TITLE NGL-2 Is a New Partner of PAR Complex in Axon Differentiation
JOURNAL J Neurosci 35 (18), 7153-7164 (2015)
PUBMED 25948265
REMARK GeneRIF: PAR3 interacts with PAR6 and NGL-2, acting together to
regulate axon differentiation.
REFERENCE 4 (bases 1 to 5500)
AUTHORS Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M,
Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I,
Darchen F, Desnos C, Pierobon P and Lennon-Dumenil AM.
TITLE Polarity protein Par3 controls B-cell receptor dynamics and antigen
extraction at the immune synapse
JOURNAL Mol Biol Cell 26 (7), 1273-1285 (2015)
PUBMED 25631815
REMARK GeneRIF: Par3 emerges as a key molecule in the coupling of the
early and late events needed for efficient extraction and
processing of immobilized antigen by B-cells.
REFERENCE 5 (bases 1 to 5500)
AUTHORS Zhang Y, Wang W, Chen J, Zhang K, Gao F, Gao B, Zhang S, Dong M,
Besenbacher F, Gong W, Zhang M, Sun F and Feng W.
TITLE Structural insights into the intrinsic self-assembly of Par-3
N-terminal domain
JOURNAL Structure 21 (6), 997-1006 (2013)
PUBMED 23643951
REFERENCE 6 (bases 1 to 5500)
AUTHORS Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y and Ohno S.
TITLE Association of ASIP/mPAR-3 with adherens junctions of mouse
neuroepithelial cells
JOURNAL Dev Dyn 225 (1), 61-69 (2002)
PUBMED 12203721
REFERENCE 7 (bases 1 to 5500)
AUTHORS Hirose T, Izumi Y, Nagashima Y, Tamai-Nagai Y, Kurihara H, Sakai T,
Suzuki Y, Yamanaka T, Suzuki A, Mizuno K and Ohno S.
TITLE Involvement of ASIP/PAR-3 in the promotion of epithelial tight
junction formation
JOURNAL J Cell Sci 115 (Pt 12), 2485-2495 (2002)
PUBMED 12045219
REFERENCE 8 (bases 1 to 5500)
AUTHORS Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK,
Ohno S and Vestweber D.
TITLE The cell polarity protein ASIP/PAR-3 directly associates with
junctional adhesion molecule (JAM)
JOURNAL EMBO J 20 (14), 3738-3748 (2001)
PUBMED 11447115
REFERENCE 9 (bases 1 to 5500)
AUTHORS Johansson A, Driessens M and Aspenstrom P.
TITLE The mammalian homologue of the Caenorhabditis elegans polarity
protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
Rac1
JOURNAL J Cell Sci 113 (Pt 18), 3267-3275 (2000)
PUBMED 10954424
REFERENCE 10 (bases 1 to 5500)
AUTHORS Izumi Y, Hirose T, Tamai Y, Hirai S, Nagashima Y, Fujimoto T,
Tabuse Y, Kemphues KJ and Ohno S.
TITLE An atypical PKC directly associates and colocalizes at the
epithelial tight junction with ASIP, a mammalian homologue of
Caenorhabditis elegans polarity protein PAR-3
JOURNAL J Cell Biol 143 (1), 95-106 (1998)
PUBMED 9763423
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AB005549.1.
[WARNING] On Nov 26, 2020 this sequence was replaced by
NM_031235.2.
Summary: may mediate the establishment and maintenance of
epithelial cell polarity [RGD, Feb 2006].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB005549.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00052296, SAMD00052297
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..5500
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="19"
/map="19q12"
gene 1..5500
/gene="Pard3"
/gene_synonym="Par3"
/note="par-3 family cell polarity regulator"
/db_xref="GeneID:81918"
/db_xref="RGD:620374"
exon 1..379
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
misc_feature 164..166
/gene="Pard3"
/gene_synonym="Par3"
/note="upstream in-frame stop codon"
CDS 260..4273
/gene="Pard3"
/gene_synonym="Par3"
/note="ASBP; ASIP; PARD-3; atypical PKC-specific binding
protein; three-PDZ containing protein similar to C.
elegans PAR3 (partitioning defect); par-3 (partitioning
defective 3) homolog; atypical PKC
isotype-specific-interacting protein"
/codon_start=1
/product="partitioning defective 3 homolog"
/protein_id="NP_112514.1"
/db_xref="GeneID:81918"
/db_xref="RGD:620374"
/translation="MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNY
WIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPE
IFGSELGTNNVSAFRPYQTTSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNF
SSEEPSRKNPTRWSTTAGFLKQNTTGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNA
RSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQ
VPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRN
RRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREMNNYSPGRFSPDSHCVANR
SVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPTAPALAPPNVLSTSVGSV
YNTKRVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAG
DRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQSP
KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSI
INGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVAR
RISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMG
ESGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKA
TISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSNASQLDFVKTRKSKSMDLG
IADETKLNTVDDQRAGSPNRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPR
IIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSY
SLERQMNGDPEKRDKAEKKKDKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHR
KDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHR
TFGCDDELLYGGMSSYDGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTP
SNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQRQ
RQEERESFQQAQRQYSSLPRQSRKNASSVSQDSWEQNYAPGEGFQSAKENPRYSSYQG
SRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGVRGPFRQDVPPSPSQV
ARLNRLQTPEKGRPFYS"
misc_feature 332..334
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 530..532
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 725..727
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q99NH2; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 779..781
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 1406..1408
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 1724..1726
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2333..2335
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2342..2344
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2393..3067
/gene="Pard3"
/gene_synonym="Par3"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z340.1);
Region: Interaction with PRKCI and PRKCZ.
/evidence=ECO:0000269|PubMed:9763423"
misc_feature 2402..2404
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2441..2443
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2684..2686
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2738..2740
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000269|PubMed:12045219,
ECO:0000269|PubMed:22579248; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2759..2761
/gene="Pard3"
/gene_synonym="Par3"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q99NH2; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); acetylation site"
misc_feature 2768..2770
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2810..2812
/gene="Pard3"
/gene_synonym="Par3"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q99NH2; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); acetylation site"
misc_feature 2813..2815
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2876..2878
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 2912..2914
/gene="Pard3"
/gene_synonym="Par3"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q99NH2; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); acetylation site"
misc_feature 3062..4270
/gene="Pard3"
/gene_synonym="Par3"
/note="propagated from UniProtKB/Swiss-Prot (Q9Z340.1);
Region: Interaction with FRMD4A.
/evidence=ECO:0000250|UniProtKB:Q99NH2"
misc_feature 3143..3145
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine, by AURKA.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 3170..3172
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 3176..3178
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 3395..3397
/gene="Pard3"
/gene_synonym="Par3"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q8TEW0; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); phosphorylation site"
misc_feature 4250..4252
/gene="Pard3"
/gene_synonym="Par3"
/note="N6-acetyllysine.
/evidence=ECO:0000250|UniProtKB:Q99NH2; propagated from
UniProtKB/Swiss-Prot (Q9Z340.1); acetylation site"
exon 380..481
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 482..662
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 663..841
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 842..973
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 974..1065
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1066..1149
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1150..1275
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1276..1658
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1659..1798
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1799..1927
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1928..1966
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 1967..2155
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 2156..2326
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 2327..2486
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 2487..2676
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 2677..2828
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 2829..2873
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 2874..3101
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 3102..3333
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 3334..3444
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 3445..3681
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 3682..3802
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 3803..3930
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
exon 3931..5500
/gene="Pard3"
/gene_synonym="Par3"
/inference="alignment:Splign:2.0.8"
ORIGIN
1 gccacacggc cccgggccgc cgccgagcgc gccaagacgc cgagacgccg aacaggtggc
61 cggaggctgc aggcgcccgg gcggggacag gcgagggcaa gtgaaggcgg ccgggctgga
121 catggtagcc gggcagctct gtgcggccgc ctgctcgcgc ccctagccgc cggcgcgccg
181 gcgcagcggc cccaccgcgc cctgcgtaca gtctcccggc ccagcggcgc tcgggccacg
241 gacggcgagg gacggcggca tgaaagtgac cgtgtgcttc gggaggaccc gggtggtcgt
301 gccgtgcgga gatggccgca tgaaagtttt cagccttatc cagcaggcgg tgacccgcta
361 ccggaaggcc gtggccaagg atccaaacta ctggatacag gtacatcgct tggagcatgg
421 ggacggtggg attctagacc tggatgacat cctctgtgac gttgccgatg acaaagacag
481 actggtagca gtgtttgatg agcaggatcc ccaccatgga ggagatggta cgagtgccag
541 ctccacggga acccagagtc cagagatatt cggcagtgag ctgggcacca acaatgtttc
601 tgcttttcgg ccttatcaaa ccacaagtga aattgaggtc acgccttcag tccttcgggc
661 aaatatgcct cttcacgtcc gacggagcag tgacccagct ttaactggcc tatccacttc
721 cgtcagtgat aacaactttt cctcagagga gccctccagg aaaaacccca cccgctggtc
781 cacgacagct ggctttctca agcagaacac cactggaagt cccaaaacct gcgacaggaa
841 gaaagatgaa aactacagga gcctcccacg ggatcccagt agctggtcca accagttcca
901 gagagacaac gcccgctcct ctctgagtgc cagccaccca atggtagacc ggtggctgga
961 gaagcaagaa caggacgagg aaggcacaga agaagacagc agccgagtgg agccggttgg
1021 acatgctgat actggactgg agaatatgcc caacttttcc ctcgatgata tggtaaagct
1081 cgtacaagtc cccaacgatg gagggcccct gggaatccat gtagtgcctt tcagtgctcg
1141 aggcggcaga acactggggt tgttagtgaa gcggttggag aaaggtggga aggctgaaca
1201 agaaaacctt ttccacgaga atgactgcat tgtgaggatt aacgatggag atcttcgaaa
1261 cagaagattt gagcaagcac agcatatgtt ccgccaagcc atgcgtgcgc gagtcatttg
1321 gttccacgtg gtccctgcag cgaacaagga gcagtatgaa cagctctccc aacgagagat
1381 gaacaactat tcccctggcc gcttcagccc cgacagccac tgtgtggcca acaggagtgt
1441 ggccaacaat gcgcctcagg cgttgcccag agcacccaga ctgagccagc cacctgagca
1501 gctggatgct cacccccgac tacctcatag tgctcatgcc tcaaccaaac cgcccacagc
1561 cccagccttg gctccaccga atgtgcttag taccagtgtc ggcagtgtgt acaacacgaa
1621 gagagtaggc aagaggctca acattcagct taaaaaaggt acagaaggac tgggatttag
1681 catcacttcc cgagacgtaa ctataggtgg ctcagctccc atttatgtca agaacattct
1741 tcctcgaggg gctgccattc aggatggcag gctcaaggcg ggagaccggc taatagaggt
1801 caatggagta gatttagcgg gcaagtccca ggaggaagtt gtttccctgt tgagaagcac
1861 caagatggag gggaccgtga gccttctggt ctttcgtcaa gaagaggctt tccacccaag
1921 ggaaatgaat gccgaaccca gccagatgca gagtccaaaa gaaacgaaag ccgaagacga
1981 ggacattgtt ctcacacctg acggtaccag ggagtttctg actttcgaag ttccactgaa
2041 tgactcaggg tctgcagggc ttggtgtcag cgtcaagggg aaccgctcca aagagaacca
2101 tgcagatttg gggatcttcg ttaagtccat cattaacggg ggagctgcat ctaaagatgg
2161 gaggctgagg gtaaatgacc agctgatagc tgtgaacgga gagtctctgc tgggcaaagc
2221 caaccaggaa gccatggaga ctctgaggag gtccatgtcc accgagggca acaagcgtgg
2281 catgatccag ctcatcgtgg cgaggcggat cagcagatgt aacgagttgc ggtctcctgg
2341 gagccccgct gcacccgagc tgcccataga aacagagttg gatgacagag aacgcaggat
2401 ctcacactcc ctctacagtg ggatcgaggg gctggatgag tctcccacca ggaatgccgc
2461 actcagcagg ataatgggtg agtcaggtaa atgccagctc tccccaaccg tgaacatgcc
2521 acatgatgac actgtcatga ttgaagatga caggctgcct gtgctccctc ctcacctctc
2581 tgaccagtcc tcctccagct cccatgatga cgtgggattc ataatgacag aagcaggcac
2641 gtgggccaag gctaccatca gtgactcagc cgactgctca ttgagtccag atgttgatcc
2701 ggttctcgct tttcaacgag aaggatttgg acgccagagt atgtcagaaa aacgcacaaa
2761 gcaattttca aatgccagtc aattggattt cgttaaaaca cgaaaatcaa aaagcatgga
2821 tttaggtata gctgacgaga ctaaactcaa tacagtggat gaccagagag caggctcccc
2881 caatagagat gtgggaccct ccttgggtct gaagaaatcc agctctttag aaagtctgca
2941 gacggctgtt gctgaggtga ccctgaatgg gaacattcct ttccaccgcc cacggccacg
3001 aatcatccga ggaaggggct gcaacgagag cttcagagcc gccattgaca agtcctacga
3061 taagcccatg gtggatgacg acgacgaagg catggagacc ttggaagaag acacagaaga
3121 aagttcaagg tcagggaggg agtccgtgtc cacgtccagt gatcagcctt cctattctct
3181 ggagagacaa atgaatggag acccagagaa gagggacaag gcagagaaga aaaaggacaa
3241 agccggaaag gataagaaga aagaccgaga gaaggagaag gataaactga aagccaagaa
3301 ggggatgctg aaaggcttgg gggacatgtt caggtttggc aaacatcgaa aagatgacaa
3361 gatggaaaaa atgggtcgaa taaaaatcca ggactctttc acctcagaag aggacagggt
3421 gcggatgaag gaggaacagg agaggattca agccaaaact cgagaattta gggagcggca
3481 agctcgagag cgcgactatg ctgaaatcca agatttccat cgaacatttg gctgtgatga
3541 cgagttgctg tatgggggca tgtcatccta tgatggctgc ctggctctca atgccagacc
3601 ccagagccca agagaaggtc acctgatgga cactttgtat gcacaagtaa agaaacctcg
3661 gagctccaaa cctggggaca gcaatcgatc cacccctagc aaccatgacc ggatacaacg
3721 tctacggcaa gaattccagc aagccaaaca ggatgaggac gtggaagacc ggcgccgtac
3781 ctacagcttt gagcaatctt ggtccagctc acggccagca tcgcagagtg gtcggcactc
3841 ggtgtcagtg gaggttcaag tgcagcggca gcgccaggag gagcgagaga gcttccagca
3901 ggcccagcgc cagtacagct ccctgccaag acaaagcagg aagaatgcca gctctgtatc
3961 acaggattcc tgggaacaga actacgcccc tggtgaaggc ttccagagtg ccaaggagaa
4021 ccccaggtat tccagttacc agggctccag gaacggctat ctaggtggcc atggctttaa
4081 tgccagggtc atgctggaga cccaggagct tctccgacag gagcagaggc gaaaagagca
4141 gcaactgaag aagcagccac cagcggatgg agtcagaggg cccttccggc aagatgtacc
4201 cccgtctcca tctcaggtgg ccaggctgaa cagactgcag acacccgaga aagggcggcc
4261 cttctactcc tgagctcaat ggaggatggc agcattttgt gtcatgcaat aaaggacatt
4321 tccccgtgaa gacttgtgct cctggagttt attttttaca aaaaccctcc atttggtggt
4381 actacagaac acttctgtca ctggtatcag tgcctttaag cagcaggagc aaagaaatgg
4441 aaggccttaa tgtctttgcc acgcgtatat ctcgtggaag gaccccatcc ccaccccacc
4501 ccaacctcaa gttcaaggca tctactccct gcttctcagc agtaccggaa acttcagctc
4561 catataaggt gcctgtggac gtcacagctt catcttagag aggggacccc ccctcccccc
4621 gccacgtgtt gccgacaccc gttccctgtg gacgtgacat ctcggtctct ggaggacgga
4681 agtggctgca gcatgcacca gagcgagggc tttccagaac ttcgcagcag ggctacccat
4741 gttctcccac tcggtctggg gttccctttc tttcctcaga tcctcggagc gtgaaggctc
4801 tagggtggta gtgaagaagc taagccatag gccagtgccg tttggttctg gggggtgagg
4861 gtaactttcc aactgcctta taactccacc acccatatca cagcgattct agtcagtgtt
4921 tataagtaca tgcgttcagt ttcagtcact catgacactc gggaacaagg ggcatgggag
4981 tggcccatgt gtacgcaccc cgaggaagga gataggagct gagggaagac tctctggagg
5041 agcttaggcc ggtctatcca gtccttactt tacttcgtgt caccgtaggt tgtcaaggga
5101 ggcacagagt gggacaagga aaaaggtcag tcacttggga ttctgagaat caacctcaac
5161 acagcttttg aggttgcagt caggatttgg tctcctatat cctcatacca tgtcccgacc
5221 tgacgaggcc aacattactg agtgactctg ctgtttattc acaaacagaa ggagagccat
5281 cccactcgag gacctgtcga tgtccctctg agcaccggga gtcccattct ccgtgcatgc
5341 ctgtggcacg aggccctccg tgttcccgcc gttcatctgt tggtctgaac atcctgtatt
5401 gtaaaccaag gctgggttgc taaagtgcct gagaatctcg atataaaaaa caaaaaacaa
5461 aaaatccttg ggcaaaaagc tcagagtacc atgtattaac
//