LOCUS NM_053596 2808 bp mRNA linear ROD 03-APR-2024
DEFINITION Rattus norvegicus endothelin converting enzyme 1 (Ece1), mRNA.
ACCESSION NM_053596
VERSION NM_053596.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2808)
AUTHORS Bao,N., Fang,B., Lv,H., Jiang,Y., Chen,F., Wang,Z. and Ma,H.
TITLE Upregulation of miR-199a-5p Protects Spinal Cord Against
Ischemia/Reperfusion-Induced Injury via Downregulation of ECE1 in
Rat
JOURNAL Cell Mol Neurobiol 38 (6), 1293-1303 (2018)
PUBMED 29948551
REMARK GeneRIF: that miR-199a-5p might protect the spinal cord against
I/R-induced injury by negatively regulating the ECE1 which could
aid in developing new therapeutic strategies for I/R-induced spinal
cord injury
REFERENCE 2 (bases 1 to 2808)
AUTHORS Sotnikova,R., Okruhlicova,L., Vlkovicova,J., Navarova,J.,
Gajdacova,B., Pivackova,L., Fialova,S. and Krenek,P.
TITLE Rosmarinic acid administration attenuates diabetes-induced vascular
dysfunction of the rat aorta
JOURNAL J Pharm Pharmacol 65 (5), 713-723 (2013)
PUBMED 23600389
REFERENCE 3 (bases 1 to 2808)
AUTHORS McNeish,A.J., Roux,B.T., Aylett,S.B., Van Den Brink,A.M. and
Cottrell,G.S.
TITLE Endosomal proteolysis regulates calcitonin gene-related peptide
responses in mesenteric arteries
JOURNAL Br J Pharmacol 167 (8), 1679-1690 (2012)
PUBMED 22881710
REMARK GeneRIF: ECE1 regulated the resensitization of responses to
calcitonin gene-related peptide in rat mesenteric artery smooth
muscle cells and mesenteric arteries, hence, ECE1 inhibitors may
attenuate an important vasodilatory pathway implicated in headaches
REFERENCE 4 (bases 1 to 2808)
AUTHORS Pelayo,J.C., Poole,D.P., Steinhoff,M., Cottrell,G.S. and
Bunnett,N.W.
TITLE Endothelin-converting enzyme-1 regulates trafficking and signalling
of the neurokinin 1 receptor in endosomes of myenteric neurones
JOURNAL J Physiol 589 (Pt 21), 5213-5230 (2011)
PUBMED 21878523
REFERENCE 5 (bases 1 to 2808)
AUTHORS Wengenmayer,C., Krikov,M., Mueller,S., Lucht,K., Villringer,A.,
Hocher,B., Unger,T. and Thoene-Reineke,C.
TITLE Novel therapy approach in primary stroke prevention: simultaneous
inhibition of endothelin converting enzyme and neutral
endopeptidase in spontaneously hypertensive, stroke-prone rats
improves survival
JOURNAL Neurol Res 33 (2), 201-207 (2011)
PUBMED 21801596
REMARK GeneRIF: The protective effect of blocking endothelin converting
enzyme and inhibiting neutral endopeptidase offers primary stroke
prevention outcome as well as improvement of mortality.
REFERENCE 6 (bases 1 to 2808)
AUTHORS Deng,A.Y. and Rapp,J.P.
TITLE Linkage mapping of the endothelin-converting enzyme gene (Ednce) to
rat chromosome 5
JOURNAL Mamm Genome 6 (10), 759-760 (1995)
PUBMED 8563183
REFERENCE 7 (bases 1 to 2808)
AUTHORS Shimada,K., Takahashi,M., Ikeda,M. and Tanzawa,K.
TITLE Identification and characterization of two isoforms of an
endothelin-converting enzyme-1
JOURNAL FEBS Lett 371 (2), 140-144 (1995)
PUBMED 7672114
REFERENCE 8 (bases 1 to 2808)
AUTHORS Shimada,K., Matsushita,Y., Wakabayashi,K., Takahashi,M.,
Matsubara,A., Iijima,Y. and Tanzawa,K.
TITLE Cloning and functional expression of human endothelin-converting
enzyme cDNA
JOURNAL Biochem Biophys Res Commun 207 (2), 807-812 (1995)
PUBMED 7864876
REFERENCE 9 (bases 1 to 2808)
AUTHORS Schmidt,M., Kroger,B., Jacob,E., Seulberger,H., Subkowski,T.,
Otter,R., Meyer,T., Schmalzing,G. and Hillen,H.
TITLE Molecular characterization of human and bovine endothelin
converting enzyme (ECE-1)
JOURNAL FEBS Lett 356 (2-3), 238-243 (1994)
PUBMED 7805846
REFERENCE 10 (bases 1 to 2808)
AUTHORS Shimada,K., Takahashi,M. and Tanzawa,K.
TITLE Cloning and functional expression of endothelin-converting enzyme
from rat endothelial cells
JOURNAL J Biol Chem 269 (28), 18275-18278 (1994)
PUBMED 8034569
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC072504.1.
On Jun 10, 2007 this sequence version replaced NM_053596.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC072504.1, D29683.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00132261, SAMD00132262
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..2808
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..2808
/gene="Ece1"
/gene_synonym="Ece"
/note="endothelin converting enzyme 1"
/db_xref="GeneID:94204"
/db_xref="RGD:620293"
exon 1..64
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
CDS 62..2326
/gene="Ece1"
/gene_synonym="Ece"
/EC_number="3.4.24.71"
/note="ECE-1"
/codon_start=1
/product="endothelin-converting enzyme 1"
/protein_id="NP_446048.2"
/db_xref="GeneID:94204"
/db_xref="RGD:620293"
/translation="MMSSYKRATLDEEDLVDSLSEGDVYPNGLQVNFRSPRSGQRCWA
ARTSVEKRLVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPT
VDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEK
KAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTS
PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLL
GGGDEDSIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLP
FLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQ
RFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASE
IILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYT
AVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGI
LQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQ
QTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQILPTL
GLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCP
LGSPMNPRHKCEVW"
exon 65..151
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 152..293
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 294..506
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 507..628
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 629..775
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 776..841
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 842..1033
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1034..1176
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1177..1291
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1292..1402
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1403..1501
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1502..1579
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1580..1683
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1684..1794
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1795..1862
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 1863..2053
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 2054..2149
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
exon 2150..2784
/gene="Ece1"
/gene_synonym="Ece"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 cgggagccgg agccttagcg ggaggtgcat ccaaagcccg gccgttcgga gcccgcgagc
61 gatgatgtca tcctacaagc gggccacgct ggacgaagag gatctggtgg actcactctc
121 cgagggcgat gtgtacccca atggcctaca ggtgaacttc cgcagccccc ggagcggaca
181 gaggtgctgg gcagctcgga cctcggtgga gaagcggctg gtggttctgg tgacgcttct
241 ggcagcaggg ctggtggcct gcctggcagc cctaggcatc cagtaccgga caagaacgcc
301 tccggtatgt ctgactgagg cctgtgtctc agtgaccagc tccatcctaa actccatgga
361 ccccacggta gacccctgcc aggacttctt cagctacgcc tgtggtggct ggatcaaggc
421 caaccccgtt cccgacggtc actcacgctg ggggaccttc agcaacctct gggagcacaa
481 ccaagccatc attaagcatc tgctggaaaa ttccacggcc agcgcgagcg aggcagagaa
541 aaaggcgcaa gtgtactacc gtgcgtgtat gaacgaaact aggatcgagg agcttcgggc
601 caagcccctg atggagctga ttgagaagct cggaggttgg aatatcacag gaccctgggc
661 caaggacaac ttccaggaca cgctgcaggt ggtcacagcg cactaccgca cctcaccctt
721 cttctctgtc tatgtcagtg ccgactccaa gaactccaac agcaatgtga tccaggtgga
781 ccagtccggc cttggcttgc cctccagaga ctattacctg aacaagacgg aaaatgaaaa
841 ggtactgact ggctatctga actacatggt ccagctgggg aaactgctgg gtggtgggga
901 cgaggactcc atccggcccc agatgcagca gatcctggat tttgagaccg ctctggccaa
961 catcaccatc ccccaggaga agcgccggga tgaagagctc atctaccaca aagtcacggc
1021 tgctgagctg cagaccttgg cacccgccat caactggtta ccctttctga atgccatttt
1081 ttacccagtg gagatcaatg agtctgagcc catcgtggtc tacgacaagg aatacctcag
1141 acaagtctcc acactcatca acagcaccga caaatgcctg ctcaacaact acatgatgtg
1201 gaacctggta cggaaaacaa gctcctttct cgaccagcgc tttcaggatg ccgatgagaa
1261 gttcatggag gttatgtacg ggacaaagaa gacctgtctt ccccgctgga agttttgcgt
1321 gagtgacaca gaaaacaacc tgggctttgc cctgggcccc atgtttgtga aagcaacctt
1381 tgcggaggac agcaagaaca tagccagcga gatcatcctg gagatcaaga aggcattcga
1441 ggagagcctg agcaccctga aatggatgga tgaagatact cggaggtcag ccaaggagaa
1501 ggcggacgcc atctacaaca tgataggcta ccccaacttc atcatggacc ccaaggagct
1561 ggacaaagtg ttcaatgact acacagcagt tcccgatctc tactttgaga acgccatgcg
1621 atttttcaac ttctcatgga gggtcacagc cgaccagctc aggaaagccc ccaacagaga
1681 tcagtggagt atgaccccgc ccatggtgaa cgcctactac tcgcccacca agaacgagat
1741 tgtgtttcca gctggaatcc tgcaggcgcc attttatacc cgctcttcgc ccaacgcctt
1801 gaactttggt ggtatcgggg tcgttgtggg ccacgagctg actcatgctt tcgacgatca
1861 aggccgggag tatgacaagg atgggaacct ccggccctgg tggaagaact cgtcggtgga
1921 ggcattcaag cagcagaccg agtgcatggt acagcagtat aacaactaca gtgtgaacgg
1981 agagcccgtg aatgggcggc acaccctcgg ggagaacatc gcggacaacg ggggactcaa
2041 ggcagcctac cgggcgtacc agaactgggt aaagaagaac ggagctgagc agatactgcc
2101 caccctgggt ctcaccagca accagctctt cttcctggga ttcgcacagg tctggtgctc
2161 ggtccgcaca ccagagagct cccacgaagg cctcatcacc gatccgcaca gcccctcccg
2221 cttccgggtc atcggctcac tctccaactc caaggagttc tcagaacact tccgctgccc
2281 gctcggctcc cccatgaacc ctcgccacaa atgcgaagtc tggtaagggc tgaagcgcag
2341 agaacacagg tggaagaagg gaaggggcct gcagccagct cccgggaaca gggccgcgct
2401 gtcaccctcc ttccagcccc tcggccgagg gccccttccc caccctggag ggtatgcagc
2461 catcttgtct aagcctatgc cagaggctca gcactggaag ccaacatttg acccccttcg
2521 aagctccagc atcccagaca cccttgagtg atgctatacc gggcctttgg gtgtgtcaag
2581 ctggtggctt gccagccctg ggcctcacac tgacaatggc agtgggacag gaccctttgc
2641 cacgtccaat gccagatata ccacaatacc actgtgtcaa atgctttaaa gatatatttt
2701 ttggggagac tattttttaa gcattatgga atacactgga aatcttcagg gaaaatgcat
2761 ttaaaacact tttttttaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//