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Rattus norvegicus solute carrier family 1 member 6 (Slc1a6), mRNA

NCBI Reference Sequence: NM_032065.1

FASTA Graphics 

LOCUS       NM_032065               2013 bp    mRNA    linear   ROD 10-OCT-2020
DEFINITION  Rattus norvegicus solute carrier family 1 member 6 (Slc1a6), mRNA.
ACCESSION   NM_032065
VERSION     NM_032065.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Abousaab A, Warsi J, Elvira B and Lang F.
  TITLE     Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1,
            EAAT2, EAAT3, and EAAT4
  JOURNAL   J Membr Biol 249 (3), 239-249 (2016)
   PUBMED   26690923
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Dalet A, Bonsacquet J, Gaboyard-Niay S, Calin-Jageman I,
            Chidavaenzi RL, Venteo S, Desmadryl G, Goldberg JM, Lysakowski A
            and Chabbert C.
  TITLE     Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular
            hair cells and calyx endings
  JOURNAL   PLoS One 7 (9), e46261 (2012)
   PUBMED   23049999
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Machtens JP, Kovermann P and Fahlke C.
  TITLE     Substrate-dependent gating of anion channels associated with
            excitatory amino acid transporter 4
  JOURNAL   J Biol Chem 286 (27), 23780-23788 (2011)
   PUBMED   21572047
  REMARK    GeneRIF: strate-dependent gating of anion channels associated with
            excitatory amino acid transporter 4.
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J,
            Gameiro A, Grewer C and Fahlke C.
  TITLE     Hetero-oligomerization of neuronal glutamate transporters
  JOURNAL   J Biol Chem 286 (5), 3935-3943 (2011)
   PUBMED   21127051
  REMARK    GeneRIF: EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2
            and EAAT3 are capable of co-assembling into heterotrimers.
            Co-expression of EAAT3 and EAAT4 results in additional appearance
            of basolateral EAAT3
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Satake S, Song SY, Konishi S and Imoto K.
  TITLE     Glutamate transporter EAAT4 in Purkinje cells controls
            intersynaptic diffusion of climbing fiber transmitter mediating
            inhibition of GABA release from interneurons
  JOURNAL   Eur J Neurosci 32 (11), 1843-1853 (2010)
   PUBMED   21070388
  REMARK    GeneRIF: Data demonstrate that the neuronal glutamate transporter
            EAAT4 in Purkinje cells plays a critical role in the extrasynaptic
            diffusion of climbing fiber transmitters.
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Melzer N, Biela A and Fahlke C.
  TITLE     Glutamate modifies ion conduction and voltage-dependent gating of
            excitatory amino acid transporter-associated anion channels
  JOURNAL   J Biol Chem 278 (50), 50112-50119 (2003)
   PUBMED   14506254
  REMARK    GeneRIF: EAAT4 but not EAAT2 anion channels displays
            voltage-dependent gating modified by glutamate
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Cholet N, Pellerin L, Magistretti PJ and Hamel E.
  TITLE     Similar perisynaptic glial localization for the Na+,K+-ATPase alpha
            2 subunit and the glutamate transporters GLAST and GLT-1 in the rat
            somatosensory cortex
  JOURNAL   Cereb Cortex 12 (5), 515-525 (2002)
   PUBMED   11950769
  REMARK    GeneRIF: The aspartate/glutamate transporter is localized in
            astrocytic processes around axonal or dendritic elements of
            glutamatergic axo-dendritic synaptic junctions in the
            frontoparietal somatosensory cortex.
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Dehnes Y, Chaudhry FA, Ullensvang K, Lehre KP, Storm-Mathisen J and
            Danbolt NC.
  TITLE     The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a
            glutamate-gated chloride channel concentrated near the synapse in
            parts of the dendritic membrane facing astroglia
  JOURNAL   J Neurosci 18 (10), 3606-3619 (1998)
   PUBMED   9570792
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Furuta A, Rothstein JD and Martin LJ.
  TITLE     Glutamate transporter protein subtypes are expressed differentially
            during rat CNS development
  JOURNAL   J Neurosci 17 (21), 8363-8375 (1997)
   PUBMED   9334410
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP and Amara SG.
  TITLE     An excitatory amino-acid transporter with properties of a
            ligand-gated chloride channel
  JOURNAL   Nature 375 (6532), 599-603 (1995)
   PUBMED   7791878
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U89608.1.
            
            [WARNING] On Nov 27, 2020 this sequence was replaced by
            NM_032065.2.
            
            Summary: mediates cotransport of one glutamate molecule with three
            Na+ ions and one H+ with countertransport of one K+ ion; also has a
            voltage gated anion transporter activity that is modified by
            glutamate [RGD, Feb 2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89608.1, AY286330.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMD00052296, SAMD00052297
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2013
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="solute carrier family 1 member 6"
                     /db_xref="GeneID:84012"
                     /db_xref="RGD:620340"
     misc_feature    145..147
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="upstream in-frame stop codon"
     CDS             154..1839
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /function="high-affinity glutamate transporter"
                     /note="solute carrier family 1 (high affinity
                     aspartate/glutamate transporter), member 6; high-affinity
                     neuronal glutamate transporter; sodium-dependent
                     glutamate/aspartate transporter"
                     /codon_start=1
                     /product="excitatory amino acid transporter 4"
                     /protein_id="NP_114454.1"
                     /db_xref="GeneID:84012"
                     /db_xref="RGD:620340"
                     /translation="MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTRE
                     HVRRFLRRNAFILLTVSAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVL
                     PLIVSSRVTGMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGL
                     HREGRIETVPTADAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELG
                     ASISPPSSAENETSILENVTRALGTLQEVISFEETVPVPGSANGINALGLVVFSVAFG
                     LVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGG
                     QLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGTSSSSATLP
                     ITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITT
                     ISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLG
                     DSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM"
     misc_feature    157..159
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000244|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35921.1); phosphorylation site"
     misc_feature    310..372
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    439..501
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    541..603
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    790..792
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35921.1); glycosylation site"
     misc_feature    838..840
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35921.1); glycosylation site"
     misc_feature    859..861
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O35921.1); glycosylation site"
     misc_feature    928..999
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    1027..1110
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    1174..1239
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    1306..1314
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     Region: Aspartate binding.
                     /evidence=ECO:0000250|UniProtKB:P43003"
     misc_feature    1375..1455
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
     misc_feature    1546..1560
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     Region: Aspartate binding.
                     /evidence=ECO:0000250|UniProtKB:P43003"
     misc_feature    1636..1701
                     /gene="Slc1a6"
                     /gene_synonym="EAAT4"
                     /note="propagated from UniProtKB/Swiss-Prot (O35921.1);
                     transmembrane region"
ORIGIN      
        1 gaattcggca cgagcgcaga cacagagcgg gtccctggcg ggtccctgcg gacccggcca
       61 ggcgcttccg cgggttctgg cttttgcatc ccggcgcagc gcgcaggcgg aggcgcaggc
      121 aaggcggccc cgctgacccg aggctgagac gcgatgagca gccacggcaa cagtctgttc
      181 ctgagggaga gcggcgctgg cgggggctgt ctgcaaggcc tgcaggacag tctgcagcag
      241 agagcactgc gcacgcgctt gcgcctgcag accatgaccc gagagcacgt gcggcgcttc
      301 ctgcgccgaa atgccttcat cttgctcaca gtcagcgctg tgatcattgg cgtcagcctg
      361 gcatttgcct tgcgcccata tcagctcacc taccgccaga tcaagtactt ctcttttcct
      421 ggtgagctgc tcatgaggat gctgcagatg ctggtgctac ccctcattgt ctccagccgg
      481 gtcacaggta tggcatcctt ggacaacaag gcaacaggga ggatgggaat gagggcagct
      541 gtgtactaca tggtgacgac cgtcattgca gttttcatcg gcatcctaat ggttaccatc
      601 atacatcctg ggaagggctc caaggagggg ctgcaccgtg agggccgaat tgagactgtt
      661 ccaacagctg atgctttcat ggacctggtc agaaatatgt ttccaccaaa ccttgtggag
      721 gcctgcttca aacagtttaa aacacagtac agcacacgag tggtaacaag gacgattgta
      781 aggacagaca acgggtcaga gttgggggcc tccatttctc ctccatcctc agcagaaaat
      841 gaaaccagca tcctggaaaa tgtcacccgg gccttgggca ccctgcagga ggtgataagc
      901 tttgaggaga ctgtgcctgt acctggctca gctaatggca tcaacgcttt gggcctcgtg
      961 gtcttctctg tggccttcgg gctggtcatc ggtggcatga agcacaaagg ccgtgtcctg
     1021 agggatttct tcgacagcct caatgaggct attatgaggc tggtgggcat catcatctgg
     1081 tatgcaccag tgggcatcct gttcctgatt gctggaaaga ttctggaaat ggaagacatg
     1141 gctgtccttg gaggtcagct gggcatgtac acgctgactg tcattgtcgg cttatttctt
     1201 catgctggtg gtgtgttacc cctcatctac ttccttgtca cacatcggaa cccctttccc
     1261 ttcatcggtg gtatactaca ggcactcatc acagccatgg gtacctcttc cagctctgca
     1321 actctgccta tcactttccg atgcctggag gagggcctgg gtgtggaccg ccgcatcacc
     1381 agattcgtgt tgcctgtggg ggccactgtc aacatggacg gcaccgcgct ctatgaggcc
     1441 ttggcagcca tctttattgc tcaagtcaac aactatgagc tgaaccttgg tcagatcacc
     1501 acaatcagca tcacagccac agctgccagc gtaggagcag ctggcatccc ccaggcagga
     1561 ctggttacca tggtgattgt gctcacgtct gtcggcctgc ccacagagga catcacattg
     1621 atcatagctg tggattggtt ccttgatcga cttcgtacga tgaccaatgt acttggggac
     1681 tcaattggag cagctgtcat tgagcatttg tcccaacggg agctggagct gcaagaggct
     1741 gagctgactc tacccagcct ggggaaaccc tataagtcac tcatggcaca agccaagggg
     1801 gcatcaaggg gtcggggagg taatgagagt gtcatgtgag aagcttctag ctctttgtcc
     1861 agggcggagg gaaggggctg ggaggggagt cctggggaca atctgttgca caactgactg
     1921 tgggctgcac aaacatgttc tgtgtgggtt ctctggggac tgctgagata aaagagaagg
     1981 aatgaaaggt aaaaaaaaaa aaaaaaaaaa aaa
//
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