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NCBI Reference Sequence: NM_032065.1
FASTA Graphics
LOCUS NM_032065 2013 bp mRNA linear ROD 10-OCT-2020 DEFINITION Rattus norvegicus solute carrier family 1 member 6 (Slc1a6), mRNA. ACCESSION NM_032065 VERSION NM_032065.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2013) AUTHORS Abousaab A, Warsi J, Elvira B and Lang F. TITLE Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4 JOURNAL J Membr Biol 249 (3), 239-249 (2016) PUBMED 26690923 REFERENCE 2 (bases 1 to 2013) AUTHORS Dalet A, Bonsacquet J, Gaboyard-Niay S, Calin-Jageman I, Chidavaenzi RL, Venteo S, Desmadryl G, Goldberg JM, Lysakowski A and Chabbert C. TITLE Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings JOURNAL PLoS One 7 (9), e46261 (2012) PUBMED 23049999 REFERENCE 3 (bases 1 to 2013) AUTHORS Machtens JP, Kovermann P and Fahlke C. TITLE Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4 JOURNAL J Biol Chem 286 (27), 23780-23788 (2011) PUBMED 21572047 REMARK GeneRIF: strate-dependent gating of anion channels associated with excitatory amino acid transporter 4. REFERENCE 4 (bases 1 to 2013) AUTHORS Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C and Fahlke C. TITLE Hetero-oligomerization of neuronal glutamate transporters JOURNAL J Biol Chem 286 (5), 3935-3943 (2011) PUBMED 21127051 REMARK GeneRIF: EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2 and EAAT3 are capable of co-assembling into heterotrimers. Co-expression of EAAT3 and EAAT4 results in additional appearance of basolateral EAAT3 REFERENCE 5 (bases 1 to 2013) AUTHORS Satake S, Song SY, Konishi S and Imoto K. TITLE Glutamate transporter EAAT4 in Purkinje cells controls intersynaptic diffusion of climbing fiber transmitter mediating inhibition of GABA release from interneurons JOURNAL Eur J Neurosci 32 (11), 1843-1853 (2010) PUBMED 21070388 REMARK GeneRIF: Data demonstrate that the neuronal glutamate transporter EAAT4 in Purkinje cells plays a critical role in the extrasynaptic diffusion of climbing fiber transmitters. REFERENCE 6 (bases 1 to 2013) AUTHORS Melzer N, Biela A and Fahlke C. TITLE Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels JOURNAL J Biol Chem 278 (50), 50112-50119 (2003) PUBMED 14506254 REMARK GeneRIF: EAAT4 but not EAAT2 anion channels displays voltage-dependent gating modified by glutamate REFERENCE 7 (bases 1 to 2013) AUTHORS Cholet N, Pellerin L, Magistretti PJ and Hamel E. TITLE Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex JOURNAL Cereb Cortex 12 (5), 515-525 (2002) PUBMED 11950769 REMARK GeneRIF: The aspartate/glutamate transporter is localized in astrocytic processes around axonal or dendritic elements of glutamatergic axo-dendritic synaptic junctions in the frontoparietal somatosensory cortex. REFERENCE 8 (bases 1 to 2013) AUTHORS Dehnes Y, Chaudhry FA, Ullensvang K, Lehre KP, Storm-Mathisen J and Danbolt NC. TITLE The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia JOURNAL J Neurosci 18 (10), 3606-3619 (1998) PUBMED 9570792 REFERENCE 9 (bases 1 to 2013) AUTHORS Furuta A, Rothstein JD and Martin LJ. TITLE Glutamate transporter protein subtypes are expressed differentially during rat CNS development JOURNAL J Neurosci 17 (21), 8363-8375 (1997) PUBMED 9334410 REFERENCE 10 (bases 1 to 2013) AUTHORS Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP and Amara SG. TITLE An excitatory amino-acid transporter with properties of a ligand-gated chloride channel JOURNAL Nature 375 (6532), 599-603 (1995) PUBMED 7791878 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U89608.1. [WARNING] On Nov 27, 2020 this sequence was replaced by NM_032065.2. Summary: mediates cotransport of one glutamate molecule with three Na+ ions and one H+ with countertransport of one K+ ion; also has a voltage gated anion transporter activity that is modified by glutamate [RGD, Feb 2006]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U89608.1, AY286330.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..2013 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="7" /map="7q11" gene 1..2013 /gene="Slc1a6" /gene_synonym="EAAT4" /note="solute carrier family 1 member 6" /db_xref="GeneID:84012" /db_xref="RGD:620340" misc_feature 145..147 /gene="Slc1a6" /gene_synonym="EAAT4" /note="upstream in-frame stop codon" CDS 154..1839 /gene="Slc1a6" /gene_synonym="EAAT4" /function="high-affinity glutamate transporter" /note="solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6; high-affinity neuronal glutamate transporter; sodium-dependent glutamate/aspartate transporter" /codon_start=1 /product="excitatory amino acid transporter 4" /protein_id="NP_114454.1" /db_xref="GeneID:84012" /db_xref="RGD:620340" /translation="MSSHGNSLFLRESGAGGGCLQGLQDSLQQRALRTRLRLQTMTRE HVRRFLRRNAFILLTVSAVIIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVL PLIVSSRVTGMASLDNKATGRMGMRAAVYYMVTTVIAVFIGILMVTIIHPGKGSKEGL HREGRIETVPTADAFMDLVRNMFPPNLVEACFKQFKTQYSTRVVTRTIVRTDNGSELG ASISPPSSAENETSILENVTRALGTLQEVISFEETVPVPGSANGINALGLVVFSVAFG LVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGG QLGMYTLTVIVGLFLHAGGVLPLIYFLVTHRNPFPFIGGILQALITAMGTSSSSATLP ITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITT ISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLG DSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQAKGASRGRGGNESVM" misc_feature 157..159 /gene="Slc1a6" /gene_synonym="EAAT4" /note="Phosphoserine. /evidence=ECO:0000244|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (O35921.1); phosphorylation site" misc_feature 310..372 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 439..501 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 541..603 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 790..792 /gene="Slc1a6" /gene_synonym="EAAT4" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (O35921.1); glycosylation site" misc_feature 838..840 /gene="Slc1a6" /gene_synonym="EAAT4" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (O35921.1); glycosylation site" misc_feature 859..861 /gene="Slc1a6" /gene_synonym="EAAT4" /note="N-linked (GlcNAc...) asparagine. /evidence=ECO:0000255; propagated from UniProtKB/Swiss-Prot (O35921.1); glycosylation site" misc_feature 928..999 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 1027..1110 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 1174..1239 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 1306..1314 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); Region: Aspartate binding. /evidence=ECO:0000250|UniProtKB:P43003" misc_feature 1375..1455 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" misc_feature 1546..1560 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); Region: Aspartate binding. /evidence=ECO:0000250|UniProtKB:P43003" misc_feature 1636..1701 /gene="Slc1a6" /gene_synonym="EAAT4" /note="propagated from UniProtKB/Swiss-Prot (O35921.1); transmembrane region" ORIGIN 1 gaattcggca cgagcgcaga cacagagcgg gtccctggcg ggtccctgcg gacccggcca 61 ggcgcttccg cgggttctgg cttttgcatc ccggcgcagc gcgcaggcgg aggcgcaggc 121 aaggcggccc cgctgacccg aggctgagac gcgatgagca gccacggcaa cagtctgttc 181 ctgagggaga gcggcgctgg cgggggctgt ctgcaaggcc tgcaggacag tctgcagcag 241 agagcactgc gcacgcgctt gcgcctgcag accatgaccc gagagcacgt gcggcgcttc 301 ctgcgccgaa atgccttcat cttgctcaca gtcagcgctg tgatcattgg cgtcagcctg 361 gcatttgcct tgcgcccata tcagctcacc taccgccaga tcaagtactt ctcttttcct 421 ggtgagctgc tcatgaggat gctgcagatg ctggtgctac ccctcattgt ctccagccgg 481 gtcacaggta tggcatcctt ggacaacaag gcaacaggga ggatgggaat gagggcagct 541 gtgtactaca tggtgacgac cgtcattgca gttttcatcg gcatcctaat ggttaccatc 601 atacatcctg ggaagggctc caaggagggg ctgcaccgtg agggccgaat tgagactgtt 661 ccaacagctg atgctttcat ggacctggtc agaaatatgt ttccaccaaa ccttgtggag 721 gcctgcttca aacagtttaa aacacagtac agcacacgag tggtaacaag gacgattgta 781 aggacagaca acgggtcaga gttgggggcc tccatttctc ctccatcctc agcagaaaat 841 gaaaccagca tcctggaaaa tgtcacccgg gccttgggca ccctgcagga ggtgataagc 901 tttgaggaga ctgtgcctgt acctggctca gctaatggca tcaacgcttt gggcctcgtg 961 gtcttctctg tggccttcgg gctggtcatc ggtggcatga agcacaaagg ccgtgtcctg 1021 agggatttct tcgacagcct caatgaggct attatgaggc tggtgggcat catcatctgg 1081 tatgcaccag tgggcatcct gttcctgatt gctggaaaga ttctggaaat ggaagacatg 1141 gctgtccttg gaggtcagct gggcatgtac acgctgactg tcattgtcgg cttatttctt 1201 catgctggtg gtgtgttacc cctcatctac ttccttgtca cacatcggaa cccctttccc 1261 ttcatcggtg gtatactaca ggcactcatc acagccatgg gtacctcttc cagctctgca 1321 actctgccta tcactttccg atgcctggag gagggcctgg gtgtggaccg ccgcatcacc 1381 agattcgtgt tgcctgtggg ggccactgtc aacatggacg gcaccgcgct ctatgaggcc 1441 ttggcagcca tctttattgc tcaagtcaac aactatgagc tgaaccttgg tcagatcacc 1501 acaatcagca tcacagccac agctgccagc gtaggagcag ctggcatccc ccaggcagga 1561 ctggttacca tggtgattgt gctcacgtct gtcggcctgc ccacagagga catcacattg 1621 atcatagctg tggattggtt ccttgatcga cttcgtacga tgaccaatgt acttggggac 1681 tcaattggag cagctgtcat tgagcatttg tcccaacggg agctggagct gcaagaggct 1741 gagctgactc tacccagcct ggggaaaccc tataagtcac tcatggcaca agccaagggg 1801 gcatcaaggg gtcggggagg taatgagagt gtcatgtgag aagcttctag ctctttgtcc 1861 agggcggagg gaaggggctg ggaggggagt cctggggaca atctgttgca caactgactg 1921 tgggctgcac aaacatgttc tgtgtgggtt ctctggggac tgctgagata aaagagaagg 1981 aatgaaaggt aaaaaaaaaa aaaaaaaaaa aaa //
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