LOCUS NM_019622 3322 bp mRNA linear ROD 30-MAR-2024
DEFINITION Rattus norvegicus espin (Espn), mRNA.
ACCESSION NM_019622
VERSION NM_019622.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3322)
AUTHORS Ahmed,Z.M., Jaworek,T.J., Sarangdhar,G.N., Zheng,L., Gul,K.,
Khan,S.N., Friedman,T.B., Sisk,R.A., Bartles,J.R., Riazuddin,S. and
Riazuddin,S.
TITLE Inframe deletion of human ESPN is associated with deafness,
vestibulopathy and vision impairment
JOURNAL J Med Genet 55 (7), 479-488 (2018)
PUBMED 29572253
REFERENCE 2 (bases 1 to 3322)
AUTHORS Lelli,A., Michel,V., Boutet de Monvel,J., Cortese,M.,
Bosch-Grau,M., Aghaie,A., Perfettini,I., Dupont,T., Avan,P.,
El-Amraoui,A. and Petit,C.
TITLE Class III myosins shape the auditory hair bundles by limiting
microvilli and stereocilia growth
JOURNAL J Cell Biol 212 (2), 231-244 (2016)
PUBMED 26754646
REFERENCE 3 (bases 1 to 3322)
AUTHORS Merritt,R.C., Manor,U., Salles,F.T., Grati,M., Dose,A.C.,
Unrath,W.C., Quintero,O.A., Yengo,C.M. and Kachar,B.
TITLE Myosin IIIB uses an actin-binding motif in its espin-1 cargo to
reach the tips of actin protrusions
JOURNAL Curr Biol 22 (4), 320-325 (2012)
PUBMED 22264607
REFERENCE 4 (bases 1 to 3322)
AUTHORS Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
Louvard,D. and Robine,S.
TITLE A new role for the architecture of microvillar actin bundles in
apical retention of membrane proteins
JOURNAL Mol Biol Cell 23 (2), 324-336 (2012)
PUBMED 22114352
REFERENCE 5 (bases 1 to 3322)
AUTHORS Schwander,M., Kachar,B. and Muller,U.
TITLE Review series: The cell biology of hearing
JOURNAL J Cell Biol 190 (1), 9-20 (2010)
PUBMED 20624897
REMARK Review article
REFERENCE 6 (bases 1 to 3322)
AUTHORS Sekerkova,G., Loomis,P.A., Changyaleket,B., Zheng,L., Eytan,R.,
Chen,B., Mugnaini,E. and Bartles,J.R.
TITLE Novel espin actin-bundling proteins are localized to Purkinje cell
dendritic spines and bind the Src homology 3 adapter protein
insulin receptor substrate p53
JOURNAL J Neurosci 23 (4), 1310-1319 (2003)
PUBMED 12598619
REFERENCE 7 (bases 1 to 3322)
AUTHORS Zheng,L., Sekerkova,G., Vranich,K., Tilney,L.G., Mugnaini,E. and
Bartles,J.R.
TITLE The deaf jerker mouse has a mutation in the gene encoding the espin
actin-bundling proteins of hair cell stereocilia and lacks espins
JOURNAL Cell 102 (3), 377-385 (2000)
PUBMED 10975527
REFERENCE 8 (bases 1 to 3322)
AUTHORS Chen,B., Li,A., Wang,D., Wang,M., Zheng,L. and Bartles,J.R.
TITLE Espin contains an additional actin-binding site in its N terminus
and is a major actin-bundling protein of the Sertoli cell-spermatid
ectoplasmic specialization junctional plaque
JOURNAL Mol Biol Cell 10 (12), 4327-4339 (1999)
PUBMED 10588661
REFERENCE 9 (bases 1 to 3322)
AUTHORS Bartles,J.R., Zheng,L., Li,A., Wierda,A. and Chen,B.
TITLE Small espin: a third actin-bundling protein and potential forked
protein ortholog in brush border microvilli
JOURNAL J Cell Biol 143 (1), 107-119 (1998)
PUBMED 9763424
REFERENCE 10 (bases 1 to 3322)
AUTHORS Bartles,J.R., Wierda,A. and Zheng,L.
TITLE Identification and characterization of espin, an actin-binding
protein localized to the F-actin-rich junctional plaques of Sertoli
cell ectoplasmic specializations
JOURNAL J Cell Sci 109 (Pt 6), 1229-1239 (1996)
PUBMED 8799813
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000005.1.
On Feb 5, 2015 this sequence version replaced NM_019622.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U46007.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760389 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-309 JAXUCZ010000005.1 167942676-167942984 c
310-503 JAXUCZ010000005.1 167939468-167939661 c
504-690 JAXUCZ010000005.1 167927923-167928109 c
691-873 JAXUCZ010000005.1 167927624-167927806 c
874-1005 JAXUCZ010000005.1 167927317-167927448 c
1006-1207 JAXUCZ010000005.1 167924337-167924538 c
1208-1464 JAXUCZ010000005.1 167922869-167923125 c
1465-1692 JAXUCZ010000005.1 167919836-167920063 c
1693-1885 JAXUCZ010000005.1 167919553-167919745 c
1886-2031 JAXUCZ010000005.1 167917189-167917334 c
2032-2295 JAXUCZ010000005.1 167916850-167917113 c
2296-2375 JAXUCZ010000005.1 167912328-167912407 c
2376-2387 JAXUCZ010000005.1 167912229-167912240 c
2388-3322 JAXUCZ010000005.1 167909271-167910205 c
FEATURES Location/Qualifiers
source 1..3322
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..3322
/gene="Espn"
/gene_synonym="Je"
/note="espin"
/db_xref="GeneID:56227"
/db_xref="RGD:620652"
exon 1..309
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
CDS 16..2532
/gene="Espn"
/gene_synonym="Je"
/note="Jerker, deafness locus; actin cytoskeletal
regulatory protein; ectoplasmic specialization protein"
/codon_start=1
/product="espin"
/protein_id="NP_062568.2"
/db_xref="GeneID:56227"
/db_xref="RGD:620652"
/translation="MALEQAMQAARRGDLDVLRSLHAAGLLGPSLRDPLDALPVHHAA
RSGKLHCLRYLVEEVALPAVSRARNGATPAHDAAATGYLSCLQWLLTQGGCRVQEKDN
SGATVLHLAARFGHPDVVNWLLYQGGANSAITTDTGALPIHYAAAKGDLPSMKLLVGH
YPEGVNAQTNNGATPLYLACQEGHLEVTKYLVQECSADPHLRAQDGMTPLHAAAQMGH
NPVLVWLVSFADVSFSEQDHDGATAMHFAASRGHTKVLSWLLLHGAEISQDLWGGTPL
HDAAENGELECCQILAVNGAGLDVRDHDGYTAADLADFNGHTHCSRYLRTVQTLSLEH
RVLSRDPSMDLEAKQPDSGMSSPNTTMSVQPPNFDLGSPTSTLSNYDSCSSSHSSSKG
QRSTRGARSSDLQSYMDMLNPEPRSKQGKPSSLPPPPPPSFPPPPPPGTQLPPPPPGY
PAPNPPVGLHLDNIYMQTKNKLRHVEVDSLKKEPSSGDGYSGLRRQDSGLLRQDSELL
LRHNTGLRRQDSDRKQRSFSKQPSTGDYYRQLGRSPGEPLAARPGMAHSEEAALLPGN
HVHNGCSADSKASRELPPPPPPPPLPEALSSPPPAPPLPIEGAGAACGQRRSSSSTGS
TKSFNMMSPTGDNSELLAEIKAGKSLKPTPQSKGLTTVFSGSGQPASQPESPQPAVSP
GPSRARSPTPPASGPQPLLNGSIVPAPPATLAPGVHLDVEALIPTLDEQGRPIPEWKR
QVMVRKLQQKMQEEEEQRRKEEEEEARLASLPAWRRDILRKKLEEEREQKRKEEERQK
LEEIQRAKEQSEKLRTLGYDEAKLAPWQRQVILKKGEIPK"
misc_feature 16..108
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 1"
misc_feature 118..213
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 2"
misc_feature 220..312
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 3"
misc_feature 322..411
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 4"
misc_feature 424..516
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 5"
misc_feature 526..618
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 6"
misc_feature 730..819
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 8"
misc_feature 826..915
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: ANK 9"
misc_feature 1027..1029
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1033..1395
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1039..1041
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1216..1218
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1219..1221
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1447..2154
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1507..1509
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1528..1530
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1609..1611
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 1909..1911
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9ET47; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 2026..2028
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 2038..2040
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 2056..2058
/gene="Espn"
/gene_synonym="Je"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (Q63618.2); phosphorylation site"
misc_feature 2251..2319
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2371..2466
/gene="Espn"
/gene_synonym="Je"
/note="propagated from UniProtKB/Swiss-Prot (Q63618.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 310..503
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 504..690
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 691..873
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 874..1005
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 1006..1207
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 1208..1464
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 1465..1692
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 1693..1885
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 1886..2031
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 2032..2295
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 2296..2375
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 2376..2387
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
exon 2388..3322
/gene="Espn"
/gene_synonym="Je"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 gccgagggtg acaccatggc cctggaacag gcgatgcagg cggcacggcg gggcgacctg
61 gacgtgctga ggtccctgca cgccgccggc ctgctggggc cttctctgcg cgacccgcta
121 gacgccctgc cggtgcacca tgcggcccgc tcaggcaagc tgcactgttt gcgctacttg
181 gtggaggagg ttgccctccc agctgtgtcc cgcgcgcgca acggcgccac accagcccat
241 gatgccgctg ccacgggcta cctctcttgc ctgcagtggc tgctcacaca gggtggctgc
301 agggtgcagg aaaaagataa ctctggtgcc acggtcctgc acctggctgc ccgctttggc
361 cacccggacg tggtgaactg gctgctgtac cagggcggtg cgaactctgc catcaccaca
421 gacacgggcg ccctgcctat ccactatgct gccgccaaag gagatctccc ctccatgaag
481 cttcttgtcg ggcactaccc tgagggagtg aatgcccaaa ccaacaacgg tgccacgccc
541 ctgtacctgg cgtgccagga gggccacctg gaagtgacga agtaccttgt gcaggagtgc
601 agtgcagatc cgcacctgcg cgcccaagac ggcatgaccc ccctgcatgc cgcggcgcag
661 atgggccaca acccagtcct ggtgtggctg gtgagctttg cggacgtgag cttttcggag
721 caggaccacg acggcgccac agccatgcac tttgcagcca gccgcggcca caccaaagtg
781 ctcagctggc tcctgctgca cggcgcagag atctcccagg acctgtgggg cgggaccccg
841 ctgcatgatg ctgctgagaa cggggaactg gagtgctgcc agatcctcgc ggtgaatggt
901 gcggggctgg acgtccgcga ccacgatggg tatacggctg cggacctggc tgatttcaat
961 ggccacaccc actgctcccg ctacctacgt acggtgcaaa ccctgagctt ggaacaccga
1021 gtcctgtccc gggatccatc catggacctg gaggcaaagc agccggactc aggcatgtct
1081 tcacccaaca ccaccatgtc ggtccagccg ccgaactttg accttggctc acccaccagc
1141 accctctcca actatgactc ctgctcctcc agccattcca gcagcaaggg tcagcgctct
1201 actcgaggtg ccagatcctc agacttacag agctacatgg acatgctgaa cccagagcct
1261 cggagcaagc aagggaagcc ttcatctcta ccaccaccgc caccaccaag cttccctcca
1321 ccaccacccc caggcacaca gctgccccca cctccaccag gctacccagc tcccaatccc
1381 cctgtggggc tgcatttgga taacatttac atgcagacca agaacaaact ccgccacgtg
1441 gaggtggact ccctcaagaa ggagccgagc tccggcgacg gctactcggg gctacgcagg
1501 caggattccg ggctgctcag gcaggattcg gagctgctgc tcaggcacaa caccggactg
1561 cgcaggcagg actccgaccg caaacagcgt tcattcagta aacagcccag cacgggggac
1621 tactaccgcc agctgggccg cagcccgggg gagccgctgg ccgcacgccc gggcatggcc
1681 cacagcgagg aggcggcgct gctccccggg aaccacgtgc acaacggctg ctccgcggac
1741 tccaaagcgt ccagggagct gccgccgcca ccgccgccgc cgcccctgcc cgaggccctg
1801 agttcgccgc cacccgcccc acctctgccc atcgagggcg cgggcgcagc ctgcggacag
1861 cggcgttcct catcttctac tggcagcacc aaatctttca acatgatgtc cccaacgggt
1921 gacaactcgg agttgctggc tgaaataaaa gcaggcaaga gtctgaaacc aacaccgcag
1981 agcaaggggc tgacaacagt gttctcaggc agcgggcagc cagcctccca gcctgagtca
2041 ccacagcctg cggtgtcacc tgggccatct cgggcccgga gccccacccc accagcctct
2101 gggcctcagc cactgctcaa tggcagcata gtaccggcac cacctgccac cctagcacca
2161 ggagtgcatc tggatgtgga ggccctcatc cccacacttg atgagcaggg ccggcccatc
2221 ccggagtgga agcgccaggt gatggtccgg aagctgcagc agaaaatgca ggaggaagag
2281 gagcagcgga ggaaggaaga agaggaggag gcccggctgg ccagcctgcc cgcctggaga
2341 cgagacattc ttaggaagaa gctggaggag gagagggagc agaagcgaaa agaggaggag
2401 cggcagaagc tggaggaaat ccagagggcg aaagaacagt cggagaagct gcggacacta
2461 ggatacgacg aggccaagct cgcgccctgg cagcgacagg tcatcttgaa gaagggggag
2521 atccctaagt aataggagtc tcggcctctt gcgtgtagcc tcacgagctc tgagaaatgg
2581 ggagcggccc ccagcccccg ccccatcctg tcaggttggt gcggaagggt gggagccttg
2641 agcccttccc ttcggtgcct gccggaatct tccctattcc cctccctggc cccacatccc
2701 caaccctgct gctggagtgc tctcgcgaac ccctgctgtc gcctggaaaa aaaaagtgcc
2761 caggctgctg acgcaaaaag aaaaaaagag aaagaaaaaa gatgctcatt tgcatgctca
2821 cttacatata tttgcatgtt caccgaccca gccggagctc gccccagcct cgtgggtggt
2881 gacttttcct gcagggcgca cgccctgctg cagccccctc ccccgcagcc cggaacccac
2941 attgctggcg catcctgggt ggaggcagac cccgagctcg gggaaggggt tttcctccct
3001 ccacgaccca gatctgtgct ggccaaagtt gctgcgtttc ttatcccctg cgagggtttc
3061 ctctcagtca tttgtttacc agaaaggatg aaacttgcct gtaggggcgg agctgtcgct
3121 cctgaggggc cccaccttta cacgtaccac cccctccccc cgccccagtt acgccttcca
3181 agttcccagt caggccctta gcttccctga ccctttcact gcctcaatgg tataagtgga
3241 gggccaggga tcccgcaatt gtacctgctc ctcaccctat cccccacccc cttccttccc
3301 ccattaaacc tctatccgcc aa
//