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Rattus norvegicus serine/threonine kinase 3 (Stk3), mRNA

NCBI Reference Sequence: NM_031735.1

FASTA Graphics 

LOCUS       NM_031735               2610 bp    mRNA    linear   ROD 10-OCT-2020
DEFINITION  Rattus norvegicus serine/threonine kinase 3 (Stk3), mRNA.
ACCESSION   NM_031735
VERSION     NM_031735.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2610)
  AUTHORS   Moon S, Lee OH, Lee S, Lee J, Park H, Park M, Chang EM, Park KH and
            Choi Y.
  TITLE     STK3/4 Expression Is Regulated in Uterine Endometrial Cells during
            the Estrous Cycle
  JOURNAL   Cells 8 (12), E1643 (2019)
   PUBMED   31847471
  REMARK    GeneRIF: STK3/4 Expression Is Regulated in Uterine Endometrial
            Cells during the Estrous Cycle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2610)
  AUTHORS   Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic
            S, Klezovitch O, Attisano L, McNeill H, Emili A and Vasioukhin V.
  TITLE     DLG5 connects cell polarity and Hippo signaling protein networks by
            linking PAR-1 with MST1/2
  JOURNAL   Genes Dev 30 (24), 2696-2709 (2016)
   PUBMED   28087714
REFERENCE   3  (bases 1 to 2610)
  AUTHORS   Du X, Dong Y, Shi H, Li J, Kong S, Shi D, Sun LV, Xu T, Deng K and
            Tao W.
  TITLE     Mst1 and mst2 are essential regulators of trophoblast
            differentiation and placenta morphogenesis
  JOURNAL   PLoS One 9 (3), e90701 (2014)
   PUBMED   24595170
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2610)
  AUTHORS   Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D and Luo
            X.
  TITLE     Structural basis for autoactivation of human Mst2 kinase and its
            regulation by RASSF5
  JOURNAL   Structure 21 (10), 1757-1768 (2013)
   PUBMED   23972470
REFERENCE   5  (bases 1 to 2610)
  AUTHORS   Park BH, Kim DS, Won GW, Jeon HJ, Oh BC, Lee Y, Kim EG and Lee YH.
  TITLE     Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte
            differentiation by activation of PPARgamma
  JOURNAL   PLoS One 7 (1), e30983 (2012)
   PUBMED   22292086
  REMARK    Erratum:[PLoS One. 2015;10(3):e0119098. PMID: 25785583]
REFERENCE   6  (bases 1 to 2610)
  AUTHORS   Deng Y, Pang A and Wang JH.
  TITLE     Regulation of mammalian STE20-like kinase 2 (MST2) by protein
            phosphorylation/dephosphorylation and proteolysis
  JOURNAL   J Biol Chem 278 (14), 11760-11767 (2003)
   PUBMED   12554736
REFERENCE   7  (bases 1 to 2610)
  AUTHORS   Lee KK and Yonehara S.
  TITLE     Phosphorylation and dimerization regulate nucleocytoplasmic
            shuttling of mammalian STE20-like kinase (MST)
  JOURNAL   J Biol Chem 277 (14), 12351-12358 (2002)
   PUBMED   11805089
REFERENCE   8  (bases 1 to 2610)
  AUTHORS   Lee KK, Ohyama T, Yajima N, Tsubuki S and Yonehara S.
  TITLE     MST, a physiological caspase substrate, highly sensitizes apoptosis
            both upstream and downstream of caspase activation
  JOURNAL   J Biol Chem 276 (22), 19276-19285 (2001)
   PUBMED   11278283
REFERENCE   9  (bases 1 to 2610)
  AUTHORS   Aurisicchio L, Di Lauro R and Zannini M.
  TITLE     Identification of the thyroid transcription factor-1 as a target
            for rat MST2 kinase
  JOURNAL   J Biol Chem 273 (3), 1477-1482 (1998)
   PUBMED   9430685
REFERENCE   10 (bases 1 to 2610)
  AUTHORS   Creasy CL and Chernoff J.
  TITLE     Cloning and characterization of a member of the MST subfamily of
            Ste20-like kinases
  JOURNAL   Gene 167 (1-2), 303-306 (1995)
   PUBMED   8566796
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ001529.1.
            
            [WARNING] On Nov 26, 2020 this sequence was replaced by
            NM_031735.2.
            
            Summary: has serine/threonine kinase activity; catalyzes the
            phosphorylation of thyroid transcription factor-1 [RGD, Feb 2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ001529.1, BC161844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00052296, SAMD00052297
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2610
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2610
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="serine/threonine kinase 3"
                     /db_xref="GeneID:65189"
                     /db_xref="RGD:68412"
     CDS             87..1562
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /EC_number="2.7.11.1"
                     /note="MST-2; serine/threonine kinase 3 (STE20 homolog,
                     yeast); STE20-like kinase MST2; mammalian STE20-like
                     protein kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase 3"
                     /protein_id="NP_113923.1"
                     /db_xref="GeneID:65189"
                     /db_xref="RGD:68412"
                     /translation="MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKA
                     IHKESGQVVAIKQVPVESDVQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYC
                     GAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA
                     KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK
                     PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP
                     FIKNAKPVSILRELITEGMEIKAKRHEEQQRELEDEEENSDEDELDSHTMVKTSSEGV
                     GTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPS
                     FMDYFDKQDFKNKSHENCDQSMREPCPMSNNVFPDNWRVPQDGDFDFLKNLSLEELQM
                     RLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKRRQQNF"
     misc_feature    87..89
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); acetylation site"
     misc_feature    129..131
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    435..437
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphothreonine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    624..626
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphothreonine, by autocatalysis.
                     /evidence=ECO:0000269|PubMed:12554736; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    1032..1034
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000244|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    1050..1055
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Cleavage, by caspase-3. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (O54748.1); cleavage
                     site"
     misc_feature    1092..1094
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    1236..1238
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphothreonine, by PKB/AKT1.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    1239..1241
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
     misc_feature    1416..1418
                     /gene="Stk3"
                     /gene_synonym="MST2"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13188; propagated from
                     UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
ORIGIN      
        1 gtgggcttcg gccggctgct cccaggctcc tttccttcct acggccttca cggtccattc
       61 ggtccctctt tctgccaccg gccgccatgg agcagccgcc ggcgcccaag agtaagctaa
      121 aaaagctgag tgaagacagt ttgactaagc agcctgaaga ggtctttgat gttttggaga
      181 agcttggaga agggtcttat ggaagtgttt ttaaagcaat acataaggaa tctggtcaag
      241 ttgttgcaat taagcaagta cctgttgagt cagatgttca ggaaataatc aaagaaattt
      301 ccataatgca acaatgtgac agcccttacg tggtgaagta ctatggcagt tactttaaga
      361 acacagacct ctggattgtt atggagtact gtggggccgg gtccgtttca gacataatta
      421 gattacgaaa caagacatta acggaagatg aaattgcaac tattctaaaa tccacgttga
      481 aaggattaga atatttgcat tttatgagga aaatacacag agatataaaa gctgggaata
      541 ttctcctcaa tacagaagga catgcaaagc ttgcagattt tggagtggct ggccagttaa
      601 cagacacgat ggcaaaacgc aatactgtaa taggaacccc gttttggatg gctcccgagg
      661 taattcaaga aataggttac aactgtgtgg ctgacatctg gtcccttggc attacgtcta
      721 tagaaatggc agaaggaaaa cctccttatg ctgatataca tccaatgagg gctattttta
      781 tgattcctac aaacccacca ccaacattca ggaaacctga gctctggtct gacgacttca
      841 cggattttgt gaagaagtgc ttggtgaaga gtcctgagca gagggccact gccacccagc
      901 tgttacagca tcctttcatc aagaatgcga agcccgtgtc gatattgaga gagctgatca
      961 cggaaggcat ggaaatcaag gccaagcggc atgaggagca gcagcgagag ctggaggacg
     1021 aggaggaaaa ctcggatgaa gatgagctgg attcgcacac tatggtgaag actagttcag
     1081 aaggtgtggg cacaatgcgg gccaccagca cgatgagtga aggggcccag accatgattg
     1141 aacacaacag caccatgcta gagtcggacc tggggaccat ggtgataaac agtgaggatg
     1201 aagaggagga agacggaacc atgaaaagaa atgcaacgtc accccaagta caaagacctt
     1261 ctttcatgga ctactttgat aagcaggact tcaagaacaa gagtcatgaa aattgtgatc
     1321 agagcatgcg tgagccatgc cctatgtcaa acaatgtttt tcctgacaac tggagagttc
     1381 ctcaagatgg agactttgat tttttaaaaa atctaagttt agaagaacta cagatgcggc
     1441 taaaagcact ggaccccatg atggaacgag aaatagaaga actgcatcaa agatacagtg
     1501 cgaaaagaca gcccatcctg gatgccatgg atgccaaaaa gaggaggcag cagaatttct
     1561 gaccagatcc cttctgtctc tgtgtgacca gagaccaagg aacacaggaa ttgaaggaac
     1621 tgtaatactt tttaatccct aaaatgtata ctctacaatt tttttagaag tcaaaaatga
     1681 tggtacacac ctagataaat ttcccaaaag caaactttgc agttgtgtcc tcgatgacgt
     1741 cggtttaaac ggatgagaac aatacacatg cgcacctctc tctctgccag ccgttacctg
     1801 caacagaacc aacctgcgac tgaagccgcc tgtggaggcg gagtccagcg ccattgcttt
     1861 gggctcacag cactgcaggg cttgtgttgc cctgatcttc cttcctgtgg agaagcctat
     1921 ttattgaccc cctaggtaga cttatttatt tatgcagctt tttttttttg gagggggggg
     1981 ttctaaaaaa agatcaggat agttttggtg aatgtccaga cacatcacag attgtaacac
     2041 tcaaccaaat tgtacactaa gcagggagct atgggtgtat tcctttatct ccagtaaaaa
     2101 taaagccata atgtccacat ggaccagaca attttataag tgttaattct tgattttgat
     2161 attggtacaa ataaaactat atatacatag gtcaaaaaga gttatacagt gtaaaaccaa
     2221 agaaatcaat gaatttttgc accaaaaaag tgtgggaaat atttttaaag acatgaaacc
     2281 caagaagaca gtgcagtcgt taatgtttcc tttattggtc tgtagtaact tcaagttcat
     2341 tctatgggac atgcttctgt cacagggctt ttgttgactt cattctactc ctgggaattg
     2401 gtaagcatca tgtatctgac aataaagcag taatatgttt atactaaaac tgtgtgtcct
     2461 tagggcctaa aaaatgaaag cattagaaaa aggctccttt ctgagaagca attagcattt
     2521 gtgtaattga cctgggacca gtcatttcct gcactacaca gggccatttt gatatcgtgt
     2581 tcttttatgt gttaattact atgtgtgcag
//
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