LOCUS NM_031735 2610 bp mRNA linear ROD 10-OCT-2020
DEFINITION Rattus norvegicus serine/threonine kinase 3 (Stk3), mRNA.
ACCESSION NM_031735
VERSION NM_031735.1
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2610)
AUTHORS Moon S, Lee OH, Lee S, Lee J, Park H, Park M, Chang EM, Park KH and
Choi Y.
TITLE STK3/4 Expression Is Regulated in Uterine Endometrial Cells during
the Estrous Cycle
JOURNAL Cells 8 (12), E1643 (2019)
PUBMED 31847471
REMARK GeneRIF: STK3/4 Expression Is Regulated in Uterine Endometrial
Cells during the Estrous Cycle.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2610)
AUTHORS Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen CC, Ratkovic
S, Klezovitch O, Attisano L, McNeill H, Emili A and Vasioukhin V.
TITLE DLG5 connects cell polarity and Hippo signaling protein networks by
linking PAR-1 with MST1/2
JOURNAL Genes Dev 30 (24), 2696-2709 (2016)
PUBMED 28087714
REFERENCE 3 (bases 1 to 2610)
AUTHORS Du X, Dong Y, Shi H, Li J, Kong S, Shi D, Sun LV, Xu T, Deng K and
Tao W.
TITLE Mst1 and mst2 are essential regulators of trophoblast
differentiation and placenta morphogenesis
JOURNAL PLoS One 9 (3), e90701 (2014)
PUBMED 24595170
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 2610)
AUTHORS Ni L, Li S, Yu J, Min J, Brautigam CA, Tomchick DR, Pan D and Luo
X.
TITLE Structural basis for autoactivation of human Mst2 kinase and its
regulation by RASSF5
JOURNAL Structure 21 (10), 1757-1768 (2013)
PUBMED 23972470
REFERENCE 5 (bases 1 to 2610)
AUTHORS Park BH, Kim DS, Won GW, Jeon HJ, Oh BC, Lee Y, Kim EG and Lee YH.
TITLE Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte
differentiation by activation of PPARgamma
JOURNAL PLoS One 7 (1), e30983 (2012)
PUBMED 22292086
REMARK Erratum:[PLoS One. 2015;10(3):e0119098. PMID: 25785583]
REFERENCE 6 (bases 1 to 2610)
AUTHORS Deng Y, Pang A and Wang JH.
TITLE Regulation of mammalian STE20-like kinase 2 (MST2) by protein
phosphorylation/dephosphorylation and proteolysis
JOURNAL J Biol Chem 278 (14), 11760-11767 (2003)
PUBMED 12554736
REFERENCE 7 (bases 1 to 2610)
AUTHORS Lee KK and Yonehara S.
TITLE Phosphorylation and dimerization regulate nucleocytoplasmic
shuttling of mammalian STE20-like kinase (MST)
JOURNAL J Biol Chem 277 (14), 12351-12358 (2002)
PUBMED 11805089
REFERENCE 8 (bases 1 to 2610)
AUTHORS Lee KK, Ohyama T, Yajima N, Tsubuki S and Yonehara S.
TITLE MST, a physiological caspase substrate, highly sensitizes apoptosis
both upstream and downstream of caspase activation
JOURNAL J Biol Chem 276 (22), 19276-19285 (2001)
PUBMED 11278283
REFERENCE 9 (bases 1 to 2610)
AUTHORS Aurisicchio L, Di Lauro R and Zannini M.
TITLE Identification of the thyroid transcription factor-1 as a target
for rat MST2 kinase
JOURNAL J Biol Chem 273 (3), 1477-1482 (1998)
PUBMED 9430685
REFERENCE 10 (bases 1 to 2610)
AUTHORS Creasy CL and Chernoff J.
TITLE Cloning and characterization of a member of the MST subfamily of
Ste20-like kinases
JOURNAL Gene 167 (1-2), 303-306 (1995)
PUBMED 8566796
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AJ001529.1.
[WARNING] On Nov 26, 2020 this sequence was replaced by
NM_031735.2.
Summary: has serine/threonine kinase activity; catalyzes the
phosphorylation of thyroid transcription factor-1 [RGD, Feb 2006].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ001529.1, BC161844.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMD00052296, SAMD00052297
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..2610
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="7"
/map="7q22"
gene 1..2610
/gene="Stk3"
/gene_synonym="MST2"
/note="serine/threonine kinase 3"
/db_xref="GeneID:65189"
/db_xref="RGD:68412"
CDS 87..1562
/gene="Stk3"
/gene_synonym="MST2"
/EC_number="2.7.11.1"
/note="MST-2; serine/threonine kinase 3 (STE20 homolog,
yeast); STE20-like kinase MST2; mammalian STE20-like
protein kinase 2"
/codon_start=1
/product="serine/threonine-protein kinase 3"
/protein_id="NP_113923.1"
/db_xref="GeneID:65189"
/db_xref="RGD:68412"
/translation="MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKA
IHKESGQVVAIKQVPVESDVQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYC
GAGSVSDIIRLRNKTLTEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHA
KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK
PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQRATATQLLQHP
FIKNAKPVSILRELITEGMEIKAKRHEEQQRELEDEEENSDEDELDSHTMVKTSSEGV
GTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPS
FMDYFDKQDFKNKSHENCDQSMREPCPMSNNVFPDNWRVPQDGDFDFLKNLSLEELQM
RLKALDPMMEREIEELHQRYSAKRQPILDAMDAKKRRQQNF"
misc_feature 87..89
/gene="Stk3"
/gene_synonym="MST2"
/note="N-acetylmethionine.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); acetylation site"
misc_feature 129..131
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 435..437
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphothreonine, by PKB/AKT1.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 624..626
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphothreonine, by autocatalysis.
/evidence=ECO:0000269|PubMed:12554736; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 1032..1034
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphoserine.
/evidence=ECO:0000244|PubMed:22673903; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 1050..1055
/gene="Stk3"
/gene_synonym="MST2"
/note="Cleavage, by caspase-3. /evidence=ECO:0000250;
propagated from UniProtKB/Swiss-Prot (O54748.1); cleavage
site"
misc_feature 1092..1094
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 1236..1238
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphothreonine, by PKB/AKT1.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 1239..1241
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
misc_feature 1416..1418
/gene="Stk3"
/gene_synonym="MST2"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q13188; propagated from
UniProtKB/Swiss-Prot (O54748.1); phosphorylation site"
ORIGIN
1 gtgggcttcg gccggctgct cccaggctcc tttccttcct acggccttca cggtccattc
61 ggtccctctt tctgccaccg gccgccatgg agcagccgcc ggcgcccaag agtaagctaa
121 aaaagctgag tgaagacagt ttgactaagc agcctgaaga ggtctttgat gttttggaga
181 agcttggaga agggtcttat ggaagtgttt ttaaagcaat acataaggaa tctggtcaag
241 ttgttgcaat taagcaagta cctgttgagt cagatgttca ggaaataatc aaagaaattt
301 ccataatgca acaatgtgac agcccttacg tggtgaagta ctatggcagt tactttaaga
361 acacagacct ctggattgtt atggagtact gtggggccgg gtccgtttca gacataatta
421 gattacgaaa caagacatta acggaagatg aaattgcaac tattctaaaa tccacgttga
481 aaggattaga atatttgcat tttatgagga aaatacacag agatataaaa gctgggaata
541 ttctcctcaa tacagaagga catgcaaagc ttgcagattt tggagtggct ggccagttaa
601 cagacacgat ggcaaaacgc aatactgtaa taggaacccc gttttggatg gctcccgagg
661 taattcaaga aataggttac aactgtgtgg ctgacatctg gtcccttggc attacgtcta
721 tagaaatggc agaaggaaaa cctccttatg ctgatataca tccaatgagg gctattttta
781 tgattcctac aaacccacca ccaacattca ggaaacctga gctctggtct gacgacttca
841 cggattttgt gaagaagtgc ttggtgaaga gtcctgagca gagggccact gccacccagc
901 tgttacagca tcctttcatc aagaatgcga agcccgtgtc gatattgaga gagctgatca
961 cggaaggcat ggaaatcaag gccaagcggc atgaggagca gcagcgagag ctggaggacg
1021 aggaggaaaa ctcggatgaa gatgagctgg attcgcacac tatggtgaag actagttcag
1081 aaggtgtggg cacaatgcgg gccaccagca cgatgagtga aggggcccag accatgattg
1141 aacacaacag caccatgcta gagtcggacc tggggaccat ggtgataaac agtgaggatg
1201 aagaggagga agacggaacc atgaaaagaa atgcaacgtc accccaagta caaagacctt
1261 ctttcatgga ctactttgat aagcaggact tcaagaacaa gagtcatgaa aattgtgatc
1321 agagcatgcg tgagccatgc cctatgtcaa acaatgtttt tcctgacaac tggagagttc
1381 ctcaagatgg agactttgat tttttaaaaa atctaagttt agaagaacta cagatgcggc
1441 taaaagcact ggaccccatg atggaacgag aaatagaaga actgcatcaa agatacagtg
1501 cgaaaagaca gcccatcctg gatgccatgg atgccaaaaa gaggaggcag cagaatttct
1561 gaccagatcc cttctgtctc tgtgtgacca gagaccaagg aacacaggaa ttgaaggaac
1621 tgtaatactt tttaatccct aaaatgtata ctctacaatt tttttagaag tcaaaaatga
1681 tggtacacac ctagataaat ttcccaaaag caaactttgc agttgtgtcc tcgatgacgt
1741 cggtttaaac ggatgagaac aatacacatg cgcacctctc tctctgccag ccgttacctg
1801 caacagaacc aacctgcgac tgaagccgcc tgtggaggcg gagtccagcg ccattgcttt
1861 gggctcacag cactgcaggg cttgtgttgc cctgatcttc cttcctgtgg agaagcctat
1921 ttattgaccc cctaggtaga cttatttatt tatgcagctt tttttttttg gagggggggg
1981 ttctaaaaaa agatcaggat agttttggtg aatgtccaga cacatcacag attgtaacac
2041 tcaaccaaat tgtacactaa gcagggagct atgggtgtat tcctttatct ccagtaaaaa
2101 taaagccata atgtccacat ggaccagaca attttataag tgttaattct tgattttgat
2161 attggtacaa ataaaactat atatacatag gtcaaaaaga gttatacagt gtaaaaccaa
2221 agaaatcaat gaatttttgc accaaaaaag tgtgggaaat atttttaaag acatgaaacc
2281 caagaagaca gtgcagtcgt taatgtttcc tttattggtc tgtagtaact tcaagttcat
2341 tctatgggac atgcttctgt cacagggctt ttgttgactt cattctactc ctgggaattg
2401 gtaagcatca tgtatctgac aataaagcag taatatgttt atactaaaac tgtgtgtcct
2461 tagggcctaa aaaatgaaag cattagaaaa aggctccttt ctgagaagca attagcattt
2521 gtgtaattga cctgggacca gtcatttcct gcactacaca gggccatttt gatatcgtgt
2581 tcttttatgt gttaattact atgtgtgcag
//