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NCBI Reference Sequence: NM_012863.1
FASTA Graphics
LOCUS NM_012863 3546 bp mRNA linear ROD 21-JUN-2020 DEFINITION Rattus norvegicus basic helix-loop-helix family, member a15 (Bhlha15), mRNA. ACCESSION NM_012863 XM_346425 VERSION NM_012863.1 KEYWORDS RefSeq. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 3546) AUTHORS Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y and Dynlacht BD. TITLE XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks JOURNAL Mol. Cell 27 (1), 53-66 (2007) PUBMED 17612490 REFERENCE 2 (bases 1 to 3546) AUTHORS Tran T, Jia D, Sun Y and Konieczny SF. TITLE The bHLH domain of Mistl is sufficient to activate gene transcription JOURNAL Gene Expr. 13 (4-5), 241-253 (2007) PUBMED 17605298 REMARK GeneRIF: Data suggest that Mist1 activates exocrine-specific gene transcription through an acetylation mechanism. REFERENCE 3 (bases 1 to 3546) AUTHORS Fazio EN, Everest M, Colman R, Wang R and Pin CL. TITLE Altered Glut-2 accumulation and beta-cell function in mice lacking the exocrine-specific transcription factor, Mist1 JOURNAL J. Endocrinol. 187 (3), 407-418 (2005) PUBMED 16423820 REFERENCE 4 (bases 1 to 3546) AUTHORS Luo X, Shin DM, Wang X, Konieczny SF and Muallem S. TITLE Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice JOURNAL J. Biol. Chem. 280 (13), 12668-12675 (2005) PUBMED 15665001 REFERENCE 5 (bases 1 to 3546) AUTHORS Saxlund MA, Sadler-Riggleman I and Skinner MK. TITLE Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expression JOURNAL Mol. Reprod. Dev. 68 (3), 269-278 (2004) PUBMED 15112319 REMARK GeneRIF: bHLH regulate ABP in differentiated Sertoli cells. REFERENCE 6 (bases 1 to 3546) AUTHORS Rukstalis JM, Kowalik A, Zhu L, Lidington D, Pin CL and Konieczny SF. TITLE Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1 JOURNAL J. Cell. Sci. 116 (Pt 16), 3315-3325 (2003) PUBMED 12829745 REFERENCE 7 (bases 1 to 3546) AUTHORS Pin CL, Rukstalis JM, Johnson C and Konieczny SF. TITLE The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity JOURNAL J. Cell Biol. 155 (4), 519-530 (2001) PUBMED 11696558 REFERENCE 8 (bases 1 to 3546) AUTHORS Lemercier C, Brown A, Mamani M, Ripoche J and Reiffers J. TITLE The rat Mist1 gene: structure and promoter characterization JOURNAL Gene 242 (1-2), 209-218 (2000) PUBMED 10721714 REFERENCE 9 (bases 1 to 3546) AUTHORS Butz S, Okamoto M and Sudhof TC. TITLE A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain JOURNAL Cell 94 (6), 773-782 (1998) PUBMED 9753324 REFERENCE 10 (bases 1 to 3546) AUTHORS Lemercier C, To RQ, Swanson BJ, Lyons GE and Konieczny SF. TITLE Mist1: a novel basic helix-loop-helix transcription factor exhibits a developmentally regulated expression pattern JOURNAL Dev. Biol. 182 (1), 101-113 (1997) PUBMED 9073453 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U58279.1. [WARNING] On Nov 26, 2020 this sequence was replaced by NM_012863.2. On Dec 17, 2003 this sequence version replaced XM_346425.1. Summary: basic helix-loop-helix transcription factor; may regulate gene expression in embryonic and postnatal cell lineages [RGD, Feb 2006]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U58279.1, BC061868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689598, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..3546 /organism="Rattus norvegicus" /mol_type="mRNA" /strain="Sprague-Dawley" /db_xref="taxon:10116" /chromosome="12" /map="12p11" gene 1..3546 /gene="Bhlha15" /gene_synonym="bHlH; Bhlhb8; Mist1" /note="basic helix-loop-helix family, member a15" /db_xref="GeneID:25334" /db_xref="RGD:3091" exon 1..73 /gene="Bhlha15" /gene_synonym="bHlH; Bhlhb8; Mist1" /inference="alignment:Splign:2.0.8" exon 74..3522 /gene="Bhlha15" /gene_synonym="bHlH; Bhlhb8; Mist1" /inference="alignment:Splign:2.0.8" CDS 125..718 /gene="Bhlha15" /gene_synonym="bHlH; Bhlhb8; Mist1" /note="MIST-1; class B basic helix-loop-helix protein 8; Basic helix-loop-helix transcription factor (bHlH); basic helix-loop-helix domain containing, class B, 8; muscle, intestine and stomach expression 1" /codon_start=1 /product="class A basic helix-loop-helix protein 15" /protein_id="NP_036995.1" /db_xref="GeneID:25334" /db_xref="RGD:3091" /translation="MKTKNRPPRRRTPMQDAEATPGEQTPDRSQSGSGASEVTKGLRS RTARASGTRAEVSRRRQGSSSRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHV RADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQ QQQQQQVAGAVLGVTEDQPQGHLQRYSTQIHSFREGS" misc_feature 158..160 /gene="Bhlha15" /gene_synonym="bHlH; Bhlhb8; Mist1" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:Q9QYC3; propagated from UniProtKB/Swiss-Prot (P70562.1); phosphorylation site" misc_feature 197..199 /gene="Bhlha15" /gene_synonym="bHlH; Bhlhb8; Mist1" /note="Phosphothreonine. /evidence=ECO:0000244|PubMed:22673903; propagated from UniProtKB/Swiss-Prot (P70562.1); phosphorylation site" ORIGIN 1 gcctgtggtg gctaaagcga cgtgtccttg tcccccgagg gcagcctctg cgcgtacggc 61 ctcggatccc cagtcggaag ggcctctccc agccaccacc tcctgggaaa aacagcctag 121 agctatgaag accaagaacc ggccccctcg gcgccggaca cccatgcagg acgcagaagc 181 caccccagga gagcagacgc ctgacagatc ccagtcaggc tcaggggcat cagaagtgac 241 caagggtctt cggagcagga cagcccgtgc gagcggaact cgggcagagg tcagccgccg 301 gcgacagggg tccagcagcc gcagggagaa cagcgttcag aggcggctgg agagcaatga 361 gcgagaaaga caacggatgc acaaactgaa caatgctttc caggcgctgc gggaggtcat 421 cccgcatgtg cgggctgaca agaagctctc caagatcgag accctcacac tggccaagaa 481 ctatatcaag tcgctgacag ccaccatact tactatgtcc agcagccgcc tcccggggct 541 ggaggcgcca ggtcctgcgc caggccctaa attgtaccag cattaccatc accagcagca 601 gcaacagcag cagcagcagc aggtggctgg ggccgtgctc ggtgtcaccg aggaccagcc 661 tcaaggccac ctgcaacgat actctacaca gatccacagc ttcagagagg ggagctagca 721 cgtgcttcgg gcttccggtg tgccttggca gtggtgaccc ggcctgctca tctcagctgt 781 ggtccctcta ggccacaagc cccagactgg taatgacact actgagatcg tggaggggat 841 tttgttgttg atgaaagctc ttgagaggcc ccagccgctt tgaactccta atcctcctca 901 cctccatctt ctctagggct gggactacat cattatatgg tgccacgctg gggactaaac 961 taagggctgt ctgtgggcta agcaggcacc ctaccaactg agctgcattc ccagcccaag 1021 gctgacttcg gtgactccat tttcctccaa agtcagctca gacacgaaca tgtggcagtt 1081 ttttcctagc cacccaaagg acaagggagt gatctgggcc ttcgaggtat atcaaggccc 1141 aaagctccag agaaagccta cctgtcctta ctgccttttg acaaagggtg ggcagggtgg 1201 gagagttctt gccttcctta tgattcatgt gtggccggtg agggatgatt ccagggaaaa 1261 ccttacttac aaatgtccct gctactgctg agcctaaggt ccgtcccata ttgtggggct 1321 acgggaaatt ggacccaaag tgccactcaa tcccctcagg gaatatatgg caaaaccaag 1381 tggtgtctca ttttatagga ttgccctggg cccaatttaa caactgaagt cagaaaggcc 1441 tagccaatcc cataggactt taataaggtc ggtctctctc tctctctctc tctctctctc 1501 tctctctctc tctccctccc tccctctctc tccctccctt cctccctccc cccaccccaa 1561 aatggaggtc acatgtggat gacctcatac agtgcctgga gacttctgga aaagctgcag 1621 tgtcctaggc tgtggctgac cacgacctaa ccctaagata tgagggccct gtgcggagat 1681 caggcagacc cttgaggctc tgtacaaaga gagacttctc gctgtgtccc ctctccatta 1741 caggggaacc cccattcttg gtatttcacg ttcttcttgg ttagcccgat gtatggctgc 1801 catgtgttcc ctcacgagcc gcttggactt agctcttggt acctttggtg ttttctctga 1861 ggcagaagct ggagtgacag gcatgtccct cccccgaccg gctcataaat aaggagggct 1921 gagtggttgg cagcctggct gctcgagctt ccgtccccgg gcgttcctgc cccactggct 1981 ctgacaggct tcactacttt gctgtcagtt gttccttggc ctcttccttc ctcccttgtc 2041 tctctgccca gaactaacct ggagttcctt caggggctca tacctccacc cccaccttta 2101 gaatgacagg agtctcgcta tgtagctcag gctggcccga aactgatttt ttgaacttgt 2161 gcttggtcca tcctcctgct ccagcccctc cctctgcccc caagtgttgt gaacgcagga 2221 tagggagaga gccctggcac ccgaagaaat agataaaggc tagattaggc ctgggcgcgt 2281 tggtcccctc atccagtgag acttgatctg tagcactctc cagtcctgga gagctggtct 2341 ggacccttca cggatcacac tcaggccagg tggcgactaa gggcctgtgt gttcctcagg 2401 gacggctact gggaaaggtc aatagtcagg gaattcacca gtgtgagcag aagccaggca 2461 caactccaag ttggaaaggc agagacccag atatctacct tgctaggggg gacctgccca 2521 gtggaacaca gaggcctctg ccgacagaca gtggctggct tccacatgag accgaggcca 2581 gagctgggct ccttttgtcc gaccttgcag gaagcacagg ggaaggaagc tgtccgccca 2641 aacttctgcc ctaatgcctg gctacagccc agggcctgtc caggttcact gtttggtagg 2701 gccacaacct cgtggctctt tgtcccccgt tagctgtcca gttctttaac tggtgacaca 2761 ggacctagat gtccctgggc catatcaaag ggtctttagg gactccagtc ccactaggag 2821 gctaggacaa gtctgtgata ccaggaagtc ctgttgctct gtctccctgt tccaaccagg 2881 gtgatccttt tttggaactg gagcataggt tgacctctaa cttactacgt gggggaggac 2941 gatgaacttc tgcctttatc tgttgtgctg gggctgatta gaggtaggca ttccacatcc 3001 agtttagaca gggctggggc ttgaagccag ggctcggagc atcctcagta actactctac 3061 acccctagtg tggtctcttc tgtcctgctg ggtaacgggg ctgggtttat tcaagcccct 3121 gggaagggct ggagccgccc ctccacctgt gcacctagga ttgaggccca gtgtggagaa 3181 ccagcagggc ctttatgaag aagaccctgg agagactttg tcctaagcct ccagatctca 3241 ccgacttcac atgggctcaa gcagagaaac ctgaagtgca acctgtcagg gaaaagccat 3301 gatgaacagc agggcctgcg tcttgcctgt caccgcggtg aagacgttcc ttaaattacc 3361 tggtttttct ccccctagtc ccctcagagc actaatgaaa ttgtcagctg tatatcttaa 3421 agtgaaaaga tttcacggcc actgtgctct ggtctgagga acaggtgcct ggagacctgc 3481 gcctttttta acataaatga ctaataaaaa tccgccagtc ataaaaaaaa aaaaaaaaaa 3541 aaaaaa //
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