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Rattus norvegicus basic helix-loop-helix family, member a15 (Bhlha15), mRNA

NCBI Reference Sequence: NM_012863.1

FASTA Graphics 

LOCUS       NM_012863               3546 bp    mRNA    linear   ROD 21-JUN-2020
DEFINITION  Rattus norvegicus basic helix-loop-helix family, member a15
            (Bhlha15), mRNA.
ACCESSION   NM_012863 XM_346425
VERSION     NM_012863.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3546)
  AUTHORS   Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C,
            Lennon CJ, Kluger Y and Dynlacht BD.
  TITLE     XBP1 controls diverse cell type- and condition-specific
            transcriptional regulatory networks
  JOURNAL   Mol. Cell 27 (1), 53-66 (2007)
   PUBMED   17612490
REFERENCE   2  (bases 1 to 3546)
  AUTHORS   Tran T, Jia D, Sun Y and Konieczny SF.
  TITLE     The bHLH domain of Mistl is sufficient to activate gene
            transcription
  JOURNAL   Gene Expr. 13 (4-5), 241-253 (2007)
   PUBMED   17605298
  REMARK    GeneRIF: Data suggest that Mist1 activates exocrine-specific gene
            transcription through an acetylation mechanism.
REFERENCE   3  (bases 1 to 3546)
  AUTHORS   Fazio EN, Everest M, Colman R, Wang R and Pin CL.
  TITLE     Altered Glut-2 accumulation and beta-cell function in mice lacking
            the exocrine-specific transcription factor, Mist1
  JOURNAL   J. Endocrinol. 187 (3), 407-418 (2005)
   PUBMED   16423820
REFERENCE   4  (bases 1 to 3546)
  AUTHORS   Luo X, Shin DM, Wang X, Konieczny SF and Muallem S.
  TITLE     Aberrant localization of intracellular organelles, Ca2+ signaling,
            and exocytosis in Mist1 null mice
  JOURNAL   J. Biol. Chem. 280 (13), 12668-12675 (2005)
   PUBMED   15665001
REFERENCE   5  (bases 1 to 3546)
  AUTHORS   Saxlund MA, Sadler-Riggleman I and Skinner MK.
  TITLE     Role of basic helix-loop-helix (bHLH) and CREB transcription
            factors in the regulation of Sertoli cell androgen-binding protein
            expression
  JOURNAL   Mol. Reprod. Dev. 68 (3), 269-278 (2004)
   PUBMED   15112319
  REMARK    GeneRIF: bHLH regulate ABP in differentiated Sertoli cells.
REFERENCE   6  (bases 1 to 3546)
  AUTHORS   Rukstalis JM, Kowalik A, Zhu L, Lidington D, Pin CL and Konieczny
            SF.
  TITLE     Exocrine specific expression of Connexin32 is dependent on the
            basic helix-loop-helix transcription factor Mist1
  JOURNAL   J. Cell. Sci. 116 (Pt 16), 3315-3325 (2003)
   PUBMED   12829745
REFERENCE   7  (bases 1 to 3546)
  AUTHORS   Pin CL, Rukstalis JM, Johnson C and Konieczny SF.
  TITLE     The bHLH transcription factor Mist1 is required to maintain
            exocrine pancreas cell organization and acinar cell identity
  JOURNAL   J. Cell Biol. 155 (4), 519-530 (2001)
   PUBMED   11696558
REFERENCE   8  (bases 1 to 3546)
  AUTHORS   Lemercier C, Brown A, Mamani M, Ripoche J and Reiffers J.
  TITLE     The rat Mist1 gene: structure and promoter characterization
  JOURNAL   Gene 242 (1-2), 209-218 (2000)
   PUBMED   10721714
REFERENCE   9  (bases 1 to 3546)
  AUTHORS   Butz S, Okamoto M and Sudhof TC.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
REFERENCE   10 (bases 1 to 3546)
  AUTHORS   Lemercier C, To RQ, Swanson BJ, Lyons GE and Konieczny SF.
  TITLE     Mist1: a novel basic helix-loop-helix transcription factor exhibits
            a developmentally regulated expression pattern
  JOURNAL   Dev. Biol. 182 (1), 101-113 (1997)
   PUBMED   9073453
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U58279.1.
            
            [WARNING] On Nov 26, 2020 this sequence was replaced by
            NM_012863.2.
            
            On Dec 17, 2003 this sequence version replaced XM_346425.1.
            
            Summary: basic helix-loop-helix transcription factor; may regulate
            gene expression in embryonic and postnatal cell lineages [RGD, Feb
            2006].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U58279.1, BC061868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2689598, SAMEA2689599
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3546
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..3546
                     /gene="Bhlha15"
                     /gene_synonym="bHlH; Bhlhb8; Mist1"
                     /note="basic helix-loop-helix family, member a15"
                     /db_xref="GeneID:25334"
                     /db_xref="RGD:3091"
     exon            1..73
                     /gene="Bhlha15"
                     /gene_synonym="bHlH; Bhlhb8; Mist1"
                     /inference="alignment:Splign:2.0.8"
     exon            74..3522
                     /gene="Bhlha15"
                     /gene_synonym="bHlH; Bhlhb8; Mist1"
                     /inference="alignment:Splign:2.0.8"
     CDS             125..718
                     /gene="Bhlha15"
                     /gene_synonym="bHlH; Bhlhb8; Mist1"
                     /note="MIST-1; class B basic helix-loop-helix protein 8;
                     Basic helix-loop-helix transcription factor (bHlH); basic
                     helix-loop-helix domain containing, class B, 8; muscle,
                     intestine and stomach expression 1"
                     /codon_start=1
                     /product="class A basic helix-loop-helix protein 15"
                     /protein_id="NP_036995.1"
                     /db_xref="GeneID:25334"
                     /db_xref="RGD:3091"
                     /translation="MKTKNRPPRRRTPMQDAEATPGEQTPDRSQSGSGASEVTKGLRS
                     RTARASGTRAEVSRRRQGSSSRRENSVQRRLESNERERQRMHKLNNAFQALREVIPHV
                     RADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEAPGPAPGPKLYQHYHHQQQQ
                     QQQQQQVAGAVLGVTEDQPQGHLQRYSTQIHSFREGS"
     misc_feature    158..160
                     /gene="Bhlha15"
                     /gene_synonym="bHlH; Bhlhb8; Mist1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9QYC3; propagated from
                     UniProtKB/Swiss-Prot (P70562.1); phosphorylation site"
     misc_feature    197..199
                     /gene="Bhlha15"
                     /gene_synonym="bHlH; Bhlhb8; Mist1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000244|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70562.1); phosphorylation site"
ORIGIN      
        1 gcctgtggtg gctaaagcga cgtgtccttg tcccccgagg gcagcctctg cgcgtacggc
       61 ctcggatccc cagtcggaag ggcctctccc agccaccacc tcctgggaaa aacagcctag
      121 agctatgaag accaagaacc ggccccctcg gcgccggaca cccatgcagg acgcagaagc
      181 caccccagga gagcagacgc ctgacagatc ccagtcaggc tcaggggcat cagaagtgac
      241 caagggtctt cggagcagga cagcccgtgc gagcggaact cgggcagagg tcagccgccg
      301 gcgacagggg tccagcagcc gcagggagaa cagcgttcag aggcggctgg agagcaatga
      361 gcgagaaaga caacggatgc acaaactgaa caatgctttc caggcgctgc gggaggtcat
      421 cccgcatgtg cgggctgaca agaagctctc caagatcgag accctcacac tggccaagaa
      481 ctatatcaag tcgctgacag ccaccatact tactatgtcc agcagccgcc tcccggggct
      541 ggaggcgcca ggtcctgcgc caggccctaa attgtaccag cattaccatc accagcagca
      601 gcaacagcag cagcagcagc aggtggctgg ggccgtgctc ggtgtcaccg aggaccagcc
      661 tcaaggccac ctgcaacgat actctacaca gatccacagc ttcagagagg ggagctagca
      721 cgtgcttcgg gcttccggtg tgccttggca gtggtgaccc ggcctgctca tctcagctgt
      781 ggtccctcta ggccacaagc cccagactgg taatgacact actgagatcg tggaggggat
      841 tttgttgttg atgaaagctc ttgagaggcc ccagccgctt tgaactccta atcctcctca
      901 cctccatctt ctctagggct gggactacat cattatatgg tgccacgctg gggactaaac
      961 taagggctgt ctgtgggcta agcaggcacc ctaccaactg agctgcattc ccagcccaag
     1021 gctgacttcg gtgactccat tttcctccaa agtcagctca gacacgaaca tgtggcagtt
     1081 ttttcctagc cacccaaagg acaagggagt gatctgggcc ttcgaggtat atcaaggccc
     1141 aaagctccag agaaagccta cctgtcctta ctgccttttg acaaagggtg ggcagggtgg
     1201 gagagttctt gccttcctta tgattcatgt gtggccggtg agggatgatt ccagggaaaa
     1261 ccttacttac aaatgtccct gctactgctg agcctaaggt ccgtcccata ttgtggggct
     1321 acgggaaatt ggacccaaag tgccactcaa tcccctcagg gaatatatgg caaaaccaag
     1381 tggtgtctca ttttatagga ttgccctggg cccaatttaa caactgaagt cagaaaggcc
     1441 tagccaatcc cataggactt taataaggtc ggtctctctc tctctctctc tctctctctc
     1501 tctctctctc tctccctccc tccctctctc tccctccctt cctccctccc cccaccccaa
     1561 aatggaggtc acatgtggat gacctcatac agtgcctgga gacttctgga aaagctgcag
     1621 tgtcctaggc tgtggctgac cacgacctaa ccctaagata tgagggccct gtgcggagat
     1681 caggcagacc cttgaggctc tgtacaaaga gagacttctc gctgtgtccc ctctccatta
     1741 caggggaacc cccattcttg gtatttcacg ttcttcttgg ttagcccgat gtatggctgc
     1801 catgtgttcc ctcacgagcc gcttggactt agctcttggt acctttggtg ttttctctga
     1861 ggcagaagct ggagtgacag gcatgtccct cccccgaccg gctcataaat aaggagggct
     1921 gagtggttgg cagcctggct gctcgagctt ccgtccccgg gcgttcctgc cccactggct
     1981 ctgacaggct tcactacttt gctgtcagtt gttccttggc ctcttccttc ctcccttgtc
     2041 tctctgccca gaactaacct ggagttcctt caggggctca tacctccacc cccaccttta
     2101 gaatgacagg agtctcgcta tgtagctcag gctggcccga aactgatttt ttgaacttgt
     2161 gcttggtcca tcctcctgct ccagcccctc cctctgcccc caagtgttgt gaacgcagga
     2221 tagggagaga gccctggcac ccgaagaaat agataaaggc tagattaggc ctgggcgcgt
     2281 tggtcccctc atccagtgag acttgatctg tagcactctc cagtcctgga gagctggtct
     2341 ggacccttca cggatcacac tcaggccagg tggcgactaa gggcctgtgt gttcctcagg
     2401 gacggctact gggaaaggtc aatagtcagg gaattcacca gtgtgagcag aagccaggca
     2461 caactccaag ttggaaaggc agagacccag atatctacct tgctaggggg gacctgccca
     2521 gtggaacaca gaggcctctg ccgacagaca gtggctggct tccacatgag accgaggcca
     2581 gagctgggct ccttttgtcc gaccttgcag gaagcacagg ggaaggaagc tgtccgccca
     2641 aacttctgcc ctaatgcctg gctacagccc agggcctgtc caggttcact gtttggtagg
     2701 gccacaacct cgtggctctt tgtcccccgt tagctgtcca gttctttaac tggtgacaca
     2761 ggacctagat gtccctgggc catatcaaag ggtctttagg gactccagtc ccactaggag
     2821 gctaggacaa gtctgtgata ccaggaagtc ctgttgctct gtctccctgt tccaaccagg
     2881 gtgatccttt tttggaactg gagcataggt tgacctctaa cttactacgt gggggaggac
     2941 gatgaacttc tgcctttatc tgttgtgctg gggctgatta gaggtaggca ttccacatcc
     3001 agtttagaca gggctggggc ttgaagccag ggctcggagc atcctcagta actactctac
     3061 acccctagtg tggtctcttc tgtcctgctg ggtaacgggg ctgggtttat tcaagcccct
     3121 gggaagggct ggagccgccc ctccacctgt gcacctagga ttgaggccca gtgtggagaa
     3181 ccagcagggc ctttatgaag aagaccctgg agagactttg tcctaagcct ccagatctca
     3241 ccgacttcac atgggctcaa gcagagaaac ctgaagtgca acctgtcagg gaaaagccat
     3301 gatgaacagc agggcctgcg tcttgcctgt caccgcggtg aagacgttcc ttaaattacc
     3361 tggtttttct ccccctagtc ccctcagagc actaatgaaa ttgtcagctg tatatcttaa
     3421 agtgaaaaga tttcacggcc actgtgctct ggtctgagga acaggtgcct ggagacctgc
     3481 gcctttttta acataaatga ctaataaaaa tccgccagtc ataaaaaaaa aaaaaaaaaa
     3541 aaaaaa
//
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