LOCUS NM_052805 1500 bp mRNA linear ROD 01-MAR-2022
DEFINITION Rattus norvegicus cholinergic receptor nicotinic alpha 3 subunit
(Chrna3), mRNA.
ACCESSION NM_052805 XM_001072823
VERSION NM_052805.2
KEYWORDS RefSeq.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1500)
AUTHORS Elayouby KS, Ishikawa M, Dukes AJ, Smith ACW, Lu Q, Fowler CD and
Kenny PJ.
TITLE alpha3* Nicotinic Acetylcholine Receptors in the
Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake
JOURNAL J Neurosci 41 (8), 1779-1787 (2021)
PUBMED 33380469
REMARK GeneRIF: alpha3* Nicotinic Acetylcholine Receptors in the
Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake.
REFERENCE 2 (bases 1 to 1500)
AUTHORS Perez-Morales R, Gonzalez-Zamora A, Gonzalez-Delgado MF, Calleros
Rincon EY, Olivas Calderon EH, Martinez-Ramirez OC and Rubio J.
TITLE CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated
with heavy smoking, lung cancer, and chronic obstructive pulmonary
disease in a mexican population
JOURNAL Ann Hum Genet 82 (6), 415-424 (2018)
PUBMED 29993116
REFERENCE 3 (bases 1 to 1500)
AUTHORS Sun Y, Li J, Zheng C and Zhou B.
TITLE Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the
associated with the risk of non-small cell lung cancer
JOURNAL Oncotarget 9 (2), 2435-2444 (2017)
PUBMED 29416783
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 1500)
AUTHORS Han S, Yang SH, Kim JY, Mo S, Yang E, Song KM, Ham BJ, Mechawar N,
Turecki G, Lee HW and Kim H.
TITLE Down-regulation of cholinergic signaling in the habenula induces
anhedonia-like behavior
JOURNAL Sci Rep 7 (1), 900 (2017)
PUBMED 28420875
REMARK Erratum:[Sci Rep. 2017 Dec 1;7(1):17090. PMID: 29196669]
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1500)
AUTHORS Kupiainen H, Kuokkanen M, Kontto J, Virtamo J, Salomaa V, Lindqvist
A, Kilpelainen M and Laitinen T.
TITLE CHRNA5/CHRNA3 Locus Associates with Increased Mortality among
Smokers
JOURNAL COPD 13 (4), 464-470 (2016)
PUBMED 26751916
REFERENCE 6 (bases 1 to 1500)
AUTHORS Elliott KJ, Ellis SB, Berckhan KJ, Urrutia A, Chavez-Noriega LE,
Johnson EC, Velicelebi G and Harpold MM.
TITLE Comparative structure of human neuronal alpha 2-alpha 7 and beta
2-beta 4 nicotinic acetylcholine receptor subunits and functional
expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
beta 4 subunits
JOURNAL J Mol Neurosci 7 (3), 217-228 (1996)
PUBMED 8906617
REFERENCE 7 (bases 1 to 1500)
AUTHORS Yang X, McDonough J, Fyodorov D, Morris M, Wang F and Deneris ES.
TITLE Characterization of an acetylcholine receptor alpha 3 gene promoter
and its activation by the POU domain factor SCIP/Tst-1
JOURNAL J Biol Chem 269 (14), 10252-10264 (1994)
PUBMED 8144606
REFERENCE 8 (bases 1 to 1500)
AUTHORS Loring RH, Sah DW, Landis SC and Zigmond RE.
TITLE The ultrastructural distribution of putative nicotinic receptors on
cultured neurons from the rat superior cervical ganglion
JOURNAL Neuroscience 24 (3), 1071-1080 (1988)
PUBMED 3380297
REFERENCE 9 (bases 1 to 1500)
AUTHORS Boulter J, Connolly J, Deneris E, Goldman D, Heinemann S and
Patrick J.
TITLE Functional expression of two neuronal nicotinic acetylcholine
receptors from cDNA clones identifies a gene family
JOURNAL Proc Natl Acad Sci U S A 84 (21), 7763-7767 (1987)
PUBMED 2444984
REFERENCE 10 (bases 1 to 1500)
AUTHORS Boulter,J., Evans,K., Goldman,D., Martin,G., Treco,D., Heinemann,S.
and Patrick,J.
TITLE Isolation of a cDNA clone coding for a possible neural nicotinic
acetylcholine receptor alpha-subunit
JOURNAL Nature 319 (6052), 368-374 (1986)
PUBMED 3753746
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AY574254.1.
[WARNING] On Sep 22, 2022 this sequence was replaced by
NM_052805.3.
On Jun 10, 2007 this sequence version replaced NM_052805.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AY574254.1, L31621.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMD00132261, SAMD00132262
[ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..1500
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/chromosome="8"
/map="8q24"
gene 1..1500
/gene="Chrna3"
/note="cholinergic receptor nicotinic alpha 3 subunit"
/db_xref="GeneID:25101"
/db_xref="RGD:2345"
CDS 1..1500
/gene="Chrna3"
/note="neuronal acetylcholine receptor subunit alpha-3;
cholinergic receptor, nicotinic, alpha polypeptide 3;
Acetylcholine receptor alpha 3 (neuronal nicotine);
cetylcholine receptor alpha 3 (neuronal nicotine);
acetylcholine receptor alpha3; cholinergic receptor
nicotinic alpha polypeptide 4; cholinergic receptor,
nicotinic, alpha 3 (neuronal)"
/codon_start=1
/product="neuronal acetylcholine receptor subunit alpha-3
precursor"
/protein_id="NP_434692.2"
/db_xref="GeneID:25101"
/db_xref="RGD:2345"
/translation="MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEII
RPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEF
MRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYF
PFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCC
EEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLS
LTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPT
WVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQ
DGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMK
AQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT"
sig_peptide 1..75
/gene="Chrna3"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 145..147
/gene="Chrna3"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P04757.1); glycosylation site"
misc_feature 496..498
/gene="Chrna3"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P04757.1); glycosylation site"
misc_feature 703..777
/gene="Chrna3"
/note="propagated from UniProtKB/Swiss-Prot (P04757.1);
transmembrane region"
misc_feature 799..855
/gene="Chrna3"
/note="propagated from UniProtKB/Swiss-Prot (P04757.1);
transmembrane region"
misc_feature 901..966
/gene="Chrna3"
/note="propagated from UniProtKB/Swiss-Prot (P04757.1);
transmembrane region"
misc_feature 1219..1221
/gene="Chrna3"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:16641100; propagated from
UniProtKB/Swiss-Prot (P04757.1); phosphorylation site"
misc_feature 1228..1230
/gene="Chrna3"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:16641100; propagated from
UniProtKB/Swiss-Prot (P04757.1); phosphorylation site"
misc_feature 1414..1473
/gene="Chrna3"
/note="propagated from UniProtKB/Swiss-Prot (P04757.1);
transmembrane region"
exon 1..64
/gene="Chrna3"
/inference="alignment:Splign:2.1.0"
exon 65..204
/gene="Chrna3"
/inference="alignment:Splign:2.1.0"
exon 205..249
/gene="Chrna3"
/inference="alignment:Splign:2.1.0"
exon 250..359
/gene="Chrna3"
/inference="alignment:Splign:2.1.0"
exon 360..1371
/gene="Chrna3"
/inference="alignment:Splign:2.1.0"
exon 1372..1500
/gene="Chrna3"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 atgggtgttg tgctgctccc gccgccgctg tccatgctga tgctggtgct gatgctgctg
61 ccagcggcca gtgcctcaga agctgagcac cgcctgttcc agtacctgtt cgaagattac
121 aacgagatca tccggccagt ggctaatgtg tcccatccag tcatcatcca gtttgaggtg
181 tccatgtctc agctggtgaa ggtggatgaa gtaaaccaga tcatggaaac caacctgtgg
241 ctgaagcaaa tctggaatga ctacaagctg aaatggaaac cctctgacta ccaaggggtg
301 gagttcatgc gtgttcctgc agagaagatc tggaaaccag acatcgtact gtacaacaac
361 gctgatgggg atttccaggt ggatgacaag accaaagctc tactcaagta cacaggagaa
421 gtgacttgga tcccgccggc catctttaag agctcatgca aaatcgacgt gacctacttc
481 ccattcgact accaaaactg caccatgaag ttcggctcct ggtcctacga caaggcaaag
541 atcgacctgg tcctcatcgg ctcctccatg aacctcaagg actactggga gagtggcgag
601 tgggctatca ttaaagcccc gggctacaaa catgaaatca agtacaactg ctgtgaggag
661 atctaccaag acatcacgta ctcgctgtac atccgtcgcc tgccgctgtt ctacaccatc
721 aacctcatca tcccctgcct gctcatctcc ttcctcactg tgcttgtctt ctacctgccc
781 tccgactgtg gggagaaggt gacactctgc atctctgtgc tcctctccct gactgtcttt
841 ctcctggtga tcaccgagac cattccttcc acctcgctgg tcatccccct gattggggag
901 tacctcctct tcactatgat ttttgtcacc ttgtccattg tcatcacagt ctttgtgctc
961 aatgtgcact atagaactcc aaccacacac accatgccca cttgggtcaa ggccgtgttc
1021 ttgaacctgc tccccagggt catgtttatg actaggccga ccagtggtga gggggacact
1081 cctaagacga ggaccttcta cggcgctgag ctctcaaacc tgaactgctt cagccgtgca
1141 gactccaaaa gctgcaagga aggctacccc tgccaagatg ggacctgtgg ctactgccac
1201 caccgtaggg taaaaatctc aaatttcagt gccaacctca caagaagctc cagttctgag
1261 tctgtcgacg ctgtgttgtc cctctctgcc ctgtcaccag aaatcaaaga agccatccaa
1321 agtgtgaagt acattgccga aaacatgaaa gcacagaatg tagccaaaga gattcaagat
1381 gattggaagt acgttgccat ggtgattgat cgcatctttc tctgggtttt catcctggtg
1441 tgcattttag gaacggcggg attatttctg caacccttga tggccagaga tgacacatag
//