LOCUS NM_001106851 1778 bp mRNA linear ROD 26-FEB-2024
DEFINITION Rattus norvegicus NCK adaptor protein 1 (Nck1), mRNA.
ACCESSION NM_001106851 XM_001066601 XM_001066651 XM_217246
VERSION NM_001106851.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 1778)
AUTHORS Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
Zaidel-Bar,R.
TITLE E-cadherin interactome complexity and robustness resolved by
quantitative proteomics
JOURNAL Sci Signal 7 (354), rs7 (2014)
PUBMED 25468996
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1778)
AUTHORS Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
Wulfing,C., Malissen,B. and Malissen,M.
TITLE The lymphoid lineage-specific actin-uncapping protein Rltpr is
essential for costimulation via CD28 and the development of
regulatory T cells
JOURNAL Nat Immunol 14 (8), 858-866 (2013)
PUBMED 23793062
REFERENCE 3 (bases 1 to 1778)
AUTHORS Lee,H. and Bennett,A.M.
TITLE Receptor protein tyrosine phosphatase-receptor tyrosine kinase
substrate screen identifies EphA2 as a target for LAR in cell
migration
JOURNAL Mol Cell Biol 33 (7), 1430-1441 (2013)
PUBMED 23358419
REFERENCE 4 (bases 1 to 1778)
AUTHORS Garber,J.J., Takeshima,F., Anton,I.M., Oyoshi,M.K., Lyubimova,A.,
Kapoor,A., Shibata,T., Chen,F., Alt,F.W., Geha,R.S., Leong,J.M. and
Snapper,S.B.
TITLE Enteropathogenic Escherichia coli and vaccinia virus do not require
the family of WASP-interacting proteins for pathogen-induced actin
assembly
JOURNAL Infect Immun 80 (12), 4071-4077 (2012)
PUBMED 22966049
REFERENCE 5 (bases 1 to 1778)
AUTHORS Wu,C.L., Buszard,B., Teng,C.H., Chen,W.L., Warr,C.G., Tiganis,T.
and Meng,T.C.
TITLE Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling
JOURNAL Biochem J 439 (1), 151-159 (2011)
PUBMED 21707536
REFERENCE 6 (bases 1 to 1778)
AUTHORS Benesch,S., Lommel,S., Steffen,A., Stradal,T.E., Scaplehorn,N.,
Way,M., Wehland,J. and Rottner,K.
TITLE Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle
movement depends on N-WASP and involves Nck, WIP, and Grb2
JOURNAL J Biol Chem 277 (40), 37771-37776 (2002)
PUBMED 12147689
REFERENCE 7 (bases 1 to 1778)
AUTHORS Gil,D., Schamel,W.W., Montoya,M., Sanchez-Madrid,F. and Alarcon,B.
TITLE Recruitment of Nck by CD3 epsilon reveals a ligand-induced
conformational change essential for T cell receptor signaling and
synapse formation
JOURNAL Cell 109 (7), 901-912 (2002)
PUBMED 12110186
REFERENCE 8 (bases 1 to 1778)
AUTHORS Kebache,S., Zuo,D., Chevet,E. and Larose,L.
TITLE Modulation of protein translation by Nck-1
JOURNAL Proc Natl Acad Sci U S A 99 (8), 5406-5411 (2002)
PUBMED 11959995
REMARK GeneRIF: Modulation of protein translation by Nck-1.
REFERENCE 9 (bases 1 to 1778)
AUTHORS Braverman,L.E. and Quilliam,L.A.
TITLE Identification of Grb4/Nckbeta, a src homology 2 and 3
domain-containing adapter protein having similar binding and
biological properties to Nck
JOURNAL J Biol Chem 274 (9), 5542-5549 (1999)
PUBMED 10026169
REFERENCE 10 (bases 1 to 1778)
AUTHORS Ren,R., Mayer,B.J., Cicchetti,P. and Baltimore,D.
TITLE Identification of a ten-amino acid proline-rich SH3 binding site
JOURNAL Science 259 (5098), 1157-1161 (1993)
PUBMED 8438166
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC167009.1.
On May 11, 2008 this sequence version replaced NM_001106851.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC167009.1, SRR8487231.18874.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760383, SAMEA5760494
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1778
/organism="Rattus norvegicus"
/mol_type="mRNA"
/db_xref="taxon:10116"
/chromosome="8"
/map="8q31"
gene 1..1778
/gene="Nck1"
/note="NCK adaptor protein 1"
/db_xref="GeneID:300955"
/db_xref="RGD:1310688"
exon 1..117
/gene="Nck1"
/inference="alignment:Splign:2.1.0"
exon 118..358
/gene="Nck1"
/inference="alignment:Splign:2.1.0"
misc_feature 127..129
/gene="Nck1"
/note="upstream in-frame stop codon"
CDS 133..1266
/gene="Nck1"
/note="cytoplasmic protein NCK1; non-catalytic region of
tyrosine kinase adaptor protein 1"
/codon_start=1
/product="SH2/SH3 adapter protein NCK1"
/protein_id="NP_001100321.1"
/db_xref="GeneID:300955"
/db_xref="RGD:1310688"
/translation="MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNS
MNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDTASPADDSFVDPGE
RLYDLNMPAFVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQIGWFPSNYV
TEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMD
VIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEPSPPQCDYIRPSLTGK
FAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQL
KETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS"
exon 359..1071
/gene="Nck1"
/inference="alignment:Splign:2.1.0"
exon 1072..1750
/gene="Nck1"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 ctgagagcta cgcggcggcg cagcacaggc ctcgtgcggt aacggcatcc ggccagccgc
61 ggtggcgtcc cggtgcagtc ctcaggtgac tggagccgcg ggctcggcgg agggaagtga
121 ggctgctgaa acatggctga agaagtggtg gtggtggcca aatttgatta tgtggcacag
181 caggaacaag agctggatat caagaagaat gagagattat ggctcctgga tgactctaag
241 tcctggtggc gagttcgaaa ttccatgaat aaaacaggtt ttgtcccttc taactatgtg
301 gaaagaaaaa atagtgctcg gaaagcatct attgttaaaa acctgaagga caccttaggc
361 attggaaaag tgaaaagaaa acccagtgtt ccagatacgg catctcctgc tgatgatagc
421 tttgttgatc caggagaacg tctctatgac ctcaacatgc ctgcttttgt gaagtttaac
481 tacatggctg agagagagga tgaattgtca ttgataaaag ggaccaaggt gatagtcatg
541 gagaaatgca gtgacggatg gtggcgtggc agctacaatg gacaaattgg atggttccct
601 tcaaactatg taactgaaga aggtgacagt cctttgggtg accatgtagg ttctctgtca
661 gagaagttag cagcagttgt caataaccta aatacaggtc aagtattgca cgttgtacag
721 gctctttacc cgttcagctc atccaatgat gaagaactca attttgagaa aggtgatgta
781 atggatgtta ttgaaaagcc ggaaaatgac ccagaatggt ggaaatgcag gaaaatcaat
841 ggcatggttg gcctggtgcc aaaaaactat gttaccgtca tgcagaataa tccgctaacc
901 tcaggtttgg aaccatcgcc tccacagtgt gattacatta ggccttcact cacggggaag
961 tttgctggca atccttggta ttatggcaaa gtcaccaggc accaggcaga gatggcattg
1021 aatgaaagag ggcatgaagg agacttcctc attcgcgaca gtgagtcttc gccaaatgat
1081 ttctcagtat cactaaaagc acaagggaaa aacaagcatt ttaaagtcca gctgaaagag
1141 actgtctact gcattgggca gcggaaattc agcaccatgg aggaacttgt agaacattac
1201 aaaaaggcac cgatctttac aagtgaacaa ggagagaaat tgtatctcgt caagcatttg
1261 tcttgatact gctcgtcagc aatgactgct acacacttta actcgtcacg cagcggaaga
1321 ctgagaaagt gttgggccag ttgtgcttgc tgggaaagtg ctgtttctaa ctgtatgaga
1381 actgactgta caatacatga gtattttgtt atgactcagc ccatacatac atattgcata
1441 ggcagtgcat ctcgtgtaga agaggtcttt attcttggtc ttctgtctta ctgttttctt
1501 tgctgttttt ctctttcctt ccaacaatta aggttttgta ttctgaaaac aaataatttg
1561 gttcaaaatc tttatatgga agaatccttt tattgctgtt tctttatttc ctcgtaaagc
1621 tatcctgttt ccccacagtc cctcttcata taaaattata tctatatggc atatgataaa
1681 ggacatttct tgtaaagtgt taatcttttc tgtgactaaa tagcaataat aaacagaaaa
1741 taagacatta aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//