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SHP2 Biochemical Assay from US Patent US12037345: "Heterobicyclic compounds for inhibiting the activity of SHP2"
Assay data:196 Active, 196 Activity ≤ 1 µM, 196 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ADP-Glo assay from US Patent US12037329: "SphK inhibitors and methods of making and using same"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
KRAS Biochemical Assay-BODIPY-GDP Exchange TR-FRET from US Patent US20240228512: "ACYCLIC OXAZEPINE COMPOUNDS COMPRISING A 6-AZA MOIETY AND USES THEREOF"
Assay data:70 Active, 62 Activity ≤ 1 nM, 70 Activity ≤ 1 µM, 70 Tested
Enzymatic Activity Test from US Patent US20240228491: "METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:88 Active, 88 Activity ≤ 1 µM, 88 Tested
Determination of the Inhibitory Activity of the Compounds of the Present Invention on PARP1 Enzyme from US Patent US20240228490: "HETEROCYCLIC DERIVATIVE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:36 Active, 14 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
PARP2 FP Assay from US Patent US20240228486: "SULFONE- AND SULFOXIMINE-BASED SELECTIVE PARP1 INHIBITORS"
Assay data:7 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Enzyme Assay from US Patent US20240228460: "PROTEASE INHIBITORS AND METHODS OF MAKING SAME"
Assay data:3 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Assay for Inhibition of Compounds Provided in the Present Application on CYP Enzymes from US Patent US20240226107: "UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) INHIBITOR"
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
In vitro activity assay for USP1 from US Patent US20240226107: "UBIQUITIN-SPECIFIC PROTEASE 1 (USP1) INHIBITOR"
Assay data:60 Active, 60 Activity ≤ 1 µM, 60 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
BET BRD Assay from US Patent US20240226096: "TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN"
Assay data:14 Active, 4 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
ALPK1 in vitro Kinase Assay from US Patent US20240226094: "ALPHA PROTEIN KINASE 1 INHIBITORS FOR USE IN TREATING KAWASAKI DISEASE"
Assay data:454 Active, 440 Activity ≤ 1 µM, 454 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
IRAK4 Kinase Assay from US Patent US12006303: "Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said substituted indazoles, and use of said substituted indazoles to produce drugs"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Erythrocyte KCa3.1 Assay from US Patent US12006289: "Potassium channel inhibitors"
Assay data:53 Active, 53 Activity ≤ 1 µM, 53 Tested
Evaluation of Inhibitory Activity Against Retinal Neovascularization by Hypoxia from US Patent US12006283: "HIF-1α inhibitor, preparation method therefor, and pharmaceutical composition for preventing or treating angiogenesis-associated eye disease, containing same as active ingredient"
Assay data:11 Active, 1 Activity ≤ 1 µM, 15 Tested
Enzyme Activity Assay from US Patent US12030897: "Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof"
The Inhibitory Effect of the Compound on the Activity of Human Liver Microsomal Cytochrome P450 Isoenzymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) from US Patent US12030897: "Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof"
Assay data:1 Tested
Lenalidomide Assay from US Patent US12030892: "CRBN modulators"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
In Vitro BRD4 (BD2) Enzymatic Activity Assay from US Patent US12030880: "Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof"
Assay data:21 Active, 15 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
In Vitro BRD4 (BD1) Enzymatic Activity Assay from US Patent US12030880: "Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof"
Assay data:21 Active, 2 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
LRRK2 Km ATP LanthaScreen Assay from US Patent US12030872: "N-heteroaryl indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof"
Assay data:38 Active, 9 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 38 Tested
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