Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Displacement of [3H]9-Dimethylamino-3-(4-methoxy-phenyl)-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one from mGluR1 in rat cerebellum membrane
Assay data:20 Active, 7 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay relative to control
Assay data:15 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat mGlu1 receptor expressed in HEK293 cells assessed as increase in intracellular calcium by FLIPR assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 15 Tested
Antagonist activity at rat mGluR1 expressed in Syrian golden hamster BHK cells assessed as potentiation of glutamate-induced calcium flux by fluorescence assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of rat mGluR1
Assay data:46 Active, 1 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 46 Tested
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of glutamate-evoked increase in calcium internalization preincubated 5 mins before glutamate challenge
Assay data:31 Active, 26 Activity ≤ 1 µM, 31 Tested
Activity at rat mGluR1 expressed in HEK293 cells assessed as calcium mobilization by FLIPR
Assay data:4 Tested
Assay data:1 Tested
Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulation
Assay data:6 Tested
Activity at rat mGluR1a assessed as effect on glutamate-stimulated calcium mobilization at 30 uM
Assay data:2 Tested
Antagonist activity at rat mGluR1 by FLIPR assay
Assay data:1 Active, 8 Tested
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate
Assay data:23 Active, 11 Activity ≤ 1 µM, 31 Tested
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as increase in calcium internalization by FLIPR assay
Assay data:32 Active, 28 Activity ≤ 1 µM, 32 Tested
Inhibition of glutamate-stimulated rat mGlu1a by calcium mobilization assay at 30 uM
Agonist activity at rat mGlu1 receptor expressed in CHO cells assessed as reversal of glutamate-activated K+ currents by electrophysiology
Assay data:11 Active, 11 Activity ≤ 1 µM, 15 Tested
Antagonist activity at rat mGluR1a receptor expressed in CHO cells assessed as effect on intracellular calcium level
Agonist activity at rat mGluR1a receptor expressed in CHO cells assessed as effect on intracellular calcium level
Assay data:10 Tested
Activity at rat recombinant mGluR1 expressed in CHO cells assessed as intracellular calcium concentration
Assay data:1 Active, 7 Tested
Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assay
Assay data:20 Active, 12 Activity ≤ 1 µM, 26 Tested
Displacement of [3H]R214127 from mGluR1 in rat cerebellum membranes
Assay data:14 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on