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Displacement of [3H]pirenzepine binding at Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.
Assay data:10 Active, 7 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ratio of ability to displace pirenzpine compared to ability to displace CD (non-selective muscarinic agonist).
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vitro evaluation for the relative maximum against muscarinic acetylcholine receptor M1 compare to muscarine
Assay data:1 Tested
In vitro evaluation for the relative maximum against Muscarinic M1 receptor compare to muscarine
The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M1r of transfected A9L cells.
The compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M1 of transfected A9L cells.
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
The compound was evaluated for inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M1 in Rat Cerebral Cortical Membranes
Assay data:3 Tested
Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M1 in rat cerebral cortical membranes at 100 uM concentration
Assay data:1 Active, 3 Tested
Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M1 in rat cerebral cortical membranes
Assay data:2 Tested
Inhibition of binding of [3H]oxotremorine M to Muscarinic acetylcholine receptor M1 in rat cerebral cortical membranes
Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested
In vitro binding affinity towards M1 receptor of rat frontal cortex homogenate by using radioligand [3H]QNB
Assay data:5 Active, 3 Activity ≤ 1 µM, 6 Tested
Half-maximal inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor M1 in rat frontal cortex homogenate
Assay data:6 Active, 3 Activity ≤ 1 µM, 8 Tested
Central postsynaptic muscarinic activity was measured relative to muscurine (100%)
Compound was tested for the inhibition of binding of [3H]N-Methyl-scopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells; ND denotes not determined
Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M1 of transfected rat A9L cells.
Assay data:25 Active, 8 Activity ≤ 1 µM, 35 Tested
Compound was tested for the binding affinity against rat cortical Muscarinic acetylcholine receptor M1 by radioligand [3H]pirenzepine binding assay.
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Compound was tested for the binding affinity against rat cortical Muscarinic acetylcholine receptor M1 by Radio ligand [3H]pirenzepine binding assay.
Assay data:1 Active, 1 Tested
Compound was tested for the Binding affinity against rat cortical Muscarinic acetylcholine receptor M1 by Radio ligand [3H]pirenzepine binding assay
Ability to displace [3H]pirenzepine radioligand for the Muscarinic acetylcholine receptor M1 in rat brain
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
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