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Inhibition of D5D in Sprague-Dawley rat liver microsomes using [14C]DGLA as substrate preincubated for 5 mins measured after 120 mins
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of rat microsomal Delta-5-desaturase
Assay data:8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of stearoyl-CoA delta5 desaturase in rat microsome
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of rat Delta(5) fatty acid desaturase by cell based assay
Inhibition of Delta(5) fatty acid desaturase in freshly isolated rat hepatocytes
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of rat delta-5 desaturase activity expressed in human HEpG2 cells
Assay data:5 Tested
Inhibition of delta6 desaturase in Sprague-Dawley rat liver microsome using cis,cis-9,12-octadecadienoic acid substrate at 10 uM
Assay data:30 Tested
Inhibition of delta5 desaturase in Sprague-Dawley rat liver microsome at 10 uM
Inhibition of delta5 desaturase in Sprague-Dawley rat liver microsome at 10 uM by thin layer chromatography method
Assay data:23 Tested
Displacement of [3H]T-3364366 from D5D in rat liver microsomal membrane preincubated for 15 mins followed by radioligand addition measured after 150 mins by TopCount microscintillation counting assay
Assay data:20 Active, 1 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 21 Tested
Binding affinity to D5D in Sprague-Dawley rat liver microsomes at 1.2 to 20 nM measured after 2.5 hrs by liquid scintillation counting
Inhibition of D5D in rat RLN10 cells using [14C]DGLA as substrate preincubated for 30 mins followed by substrate addition measured after 3 hrs
Binding affinity to D5D in Sprague-Dawley rat liver microsomes after 150 mins by liquid scintillation counting
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to D5D in Sprague-Dawley rat liver microsomes at 1.2 to 20 nM measured up to 2.5 hrs by liquid scintillation counting
Displacement of [3H]T-3364366 from D5D in Sprague-Dawley rat liver microsomes after 150 mins by liquid scintillation counting
Assay data:4 Active, 4 Tested
Reversible binding affinity to D5D in Sprague-Dawley rat liver microsomes assessed as compound bound to protein at 6 nM preincubated for 150 mins followed by 2 fold dilution by 10 uM of T-3364366 measured after 21 hrs by liquid scintillation counting relative to control
Reversible binding affinity to D5D in Sprague-Dawley rat liver microsomes assessed as dissociation half life at 6 nM preincubated for 150 mins followed by 2 fold dilution by 10 uM of T-3364366 by liquid scintillation counting
Reversible binding affinity to D5D in Sprague-Dawley rat liver microsomes after 150 mins in presence of trichloroacetate by liquid scintillation counting
Displacement of [3H]T-3364366 from D5D in Sprague-Dawley rat liver microsomes at high concentrations after 150 mins by liquid scintillation counting
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