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Inhibition of Aldose Reductase at 10 M in the Eurofins-Panlabs enzyme assay (Eurofins_assay_107000)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of Aldose Reductase at 10.0 M in the Eurofins Panlabs Safety Screen
Assay data:1 Tested
Inhibition of AKR1B1 in human HLE cells assessed as inhibition of glucose-induced sorbitol accumulation at 10 uM incubated for 24 hrs in presence of glucose
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of AKR1B1 in human HLE cells assessed as inhibition of glucose-induced sorbitol accumulation at 2 uM incubated for 24 hrs in presence of glucose
Ratio of Ki for human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3)pLysS assessed as apparent dissociation constant for EI complex to Ki for human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3)pLysS assessed as apparent dissociation constant for ESI complex
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Mixed non-competitive inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3)pLysS assessed as apparent dissociation constant for ESI complex using L-idose as substrate by secondary plot analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Mixed non-competitive inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3)pLysS assessed as apparent dissociation constant for EI complex using L-idose as substrate by secondary plot analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Reversible inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3)pLysS assessed as recovery of enzyme activity using L-idose as substrate measured after extensive dialysis by NADPH oxidation based absorbance analysis
Inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3)pLysS using L-idose as substrate by NADPH oxidation based absorbance analysis
Assay data:12 Active, 7 Activity ≤ 1 µM, 14 Tested
Inhibition of ALR2 (unknown origin)
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of rat kidney ALR1 using D-glucuronate by measuring NADPH consumption by spectrophotometric analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 7 Tested
Inhibition of AKR1B10 (unknown origin) transfected in Escherichia coli BL21 (DE3) pLysS competent cells using pyridine-3-aldehyde as substrate assessed as inhibition of NADP+ dependent substrate oxidation incubated for 10 mins
Assay data:4 Active, 8 Tested
Inhibition of AKR1B1 (unknown origin) transfected in Escherichia coli BL21 (DE3) pLysS competent cells using pyridine-3-aldehyde as substrate assessed as inhibition of NADP+ dependent substrate oxidation incubated for 10 mins
Assay data:8 Tested
Inhibition of C-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21-CodonPlus competent cells using methyl glyoxylate as substrate incubated for 2 mins in presence of NADPH
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of C-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21-CodonPlus competent cells using DL-glyceraldehyde as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Aldose Reductase Eurofins Panlabs panel
Inhibition of ARL2 (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of AR (unknown origin) assessed as glycation activity
Inhibition of ALR2 (unknown origin) using D,L-glyceraldehyde as substrate incubated for 10 mins in presence of NADPH by UV-spectrophotometric assay
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