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Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human FFAR3 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of C3 fatty acid propionate-induced [35S]GTPgammaS binding at 10 uM preincubated for 15 mins followed by C3 fatty acid propionate addition and measured after 45 mins by liquid scintillation counting analysis
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (FFA3)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Agonist activity at FFAR3 (unknown origin)
Assay data:2 Tested
Agonist activity at GPR41 (unknown origin)
Negative allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as effect on forskolin-induced cAMP production at 30 uM measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at FFA3 in C57/BL6 mouse DRG neurons assessed as increase in intracellular calcium level at 5 uM by Fura-8/AM staining based inverted fluorescence microscopy
Agonist activity at mouse FFA3 receptor
Assay data:3 Active, 3 Tested
Agonist activity at rat FFA3 receptor
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
Assay data:13 Active, 12 Activity ≤ 1 µM, 16 Tested
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay relative to propionate
Assay data:49 Tested
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
Assay data:44 Active, 17 Activity ≤ 1 µM, 64 Tested
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry relative to propionate
Assay data:21 Tested
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
Assay data:14 Active, 23 Tested
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Assay data:3 Tested
Agonist activity at human FFA3 receptor by FLIPR assay
Agonist activity at human FFA3 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by Fluo-8 dye based FLIPR assay
Agonist activity at GPR41 (unknown origin) up to 100 uM
Agonist activity at GPR41/FFA3 (unknown origin) expressed in CHO cells assessed as increase in calcium flux at 10 uM by Fluo-8 AM dye based FLIPR method
Assay data:20 Tested
Antagonist activity at FFA3R (unknown origin) assessed as inhibition of GTPgamma35S binding at 10 uM preincubated for 15 mins followed by GTPgamma35S addition measured after 2.5 hrs by SPA method relative to control
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