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Inhibition of human EAAT3 transfected in MDCK cells assessed as reduction in [14C]glutamate uptake
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human EAAT3 transfected in African green monkey COS-1 cells assessed as reduction in [14C]glutamate uptake
Inhibition of human EAAT3 transfected in African green monkey COS-1 cells assessed as inhibition of [3H]L-glutamate uptake by measuring inhibition constant
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate uptake by the Excitatory Amino Acid Transporter 3 (EAAT3, SLC1A1) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A1 cells (PubChem AID: 1794812)
SummaryRelated BioAssays by Target
Membrane potential based assay for SLC1A1 using HEK-293 SLC1A1 OE cells
Assay data:1 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human EAAT3 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human EAAT3 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillation counting analysis
Assay data:3 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting method
Assay data:37 Tested
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake at 10 uM incubated for 5 mins by liquid scintillation counting method
Assay data:1 Tested
Inhibition of EAAT3 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assay
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake after 15 mins by TopCount scintillation counting method
Assay data:4 Tested
Potency index, ratio of IC50 for NBI59159 to IC50 for test compound for inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Potency index, ratio of IC50 for WAY-213613 to IC50 for test compound for inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Potency index, ratio of IC50 for DL-TBOA to IC50 for test compound for inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Assay data:2 Tested
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in EC80 L-glutamate-induced response at 300 uM co-applied with L-glutamate addition by fluorescence-based FLIPR membrane potential blue assay
Assay data:10 Active, 10 Tested
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in EC80 L-glutamate-induced response at 300 uM pre-incubated before L-glutamate addition by fluorescence-based FLIPR membrane potential blue assay
Substrate activity at human EAAT3 expressed in HEK293 cells assessed as increase in fluorescence level at 300 uM incubated for 30 mins by fluorescence-based FLIPR membrane potential blue assay
Assay data:10 Tested
Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Assay data:20 Active, 9 Activity ≤ 1 µM, 26 Tested
Rat Excitatory amino acid transporter 3 (Glutamate transporter subfamily)
Assay data:1 Active, 1 Tested
Human Excitatory amino acid transporter 3 (Glutamate transporter subfamily)
Assay data:3 Active, 3 Tested
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