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Selectivity interaction (CEREP ligand displacement assays (non-kinase proteins)) EUB0001326b CNR1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b CNR1
Selectivity interaction (Panel of non-epigenetic targets (kinases, GPCRs, ion channels, and transporters, Eurofins) ) EUB0000271b CNR1
Selectivity interaction (Cannabinoid CB1 calcium flux assay, agonist and antagonist mode ) EUB0000877a CNR1
Inhibition of Cannabinoid CB1 at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against CB1/CENTR/H in the Eurofins SafetyScreen44 (BI) by Radioactive Assay (Old_Cerep_12)
Agonist activity in the Eurofins SafetyScreen44 (CEREP) (BI) against CB1(HU)_AGON by Scintillation counting (Cerep_4708)
Assay data:4 Tested
SafetyScreen: CB1 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay, catalogue number: 4708
Assay data:10 Tested
Displacement of [3H]-CP55940 from human CB1 receptor expressed in CHO cell membranes at 10 uM incubated for 1 hr by TopCount liquid scintillation counting analysis relative to control
Assay data:3 Tested
Agonist activity at CB1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of intracellular cAMP production measured after 45 mins by HTRF-based assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
Agonist activity at CB1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of intracellular cAMP production at 1 uM measured after 45 mins by HTRF-based assay
Displacement of [3H]SR141716A from recombinant human CB1 receptor at 10 uM by radioligand binding assay
Antagonist activity at CB1 receptor in mouse brain membrane assessed as inhibition of CP55490-induced GTPgammaS binding by [35S]GTPgammaS binding analysis
Assay data:40 Active, 40 Activity ≤ 1 µM, 45 Tested
Displacement of [3H]CP55490 from CB1 receptor in mouse brain plasma membrane by radioligand displacement analysis
Assay data:67 Active, 9 Activity ≤ 1 nM, 69 Activity ≤ 1 µM, 69 Tested
Agonist activity at CB1/CB2 (unknown origin) receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 2 hrs by microplate reader analysis
Assay data:1 Active, 1 Tested
Binding affinity to CB1 receptor (unknown origin) assessed as inhibition constant
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]CP55940 from human CB1 receptor expressed in Sf9 cell membranes assessed as inhibition constant incubated for 90 mins by by scintillation counter analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inverse agonist activity at human CB1 receptor expressed in African green monkey COS7 cells co-expressing G-protein in presence of CP55940 by IP3 assay
Assay data:33 Active, 33 Activity ≤ 1 µM, 34 Tested
Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cell membrane by GTP-gamma-S assay
Assay data:39 Active, 11 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 51 Tested
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