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Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysis
Assay data:6 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to rat TrxR1 assessed as adduct formation at 7.2 uM by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assay
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 50 mins by thio-glo reagent based fluorescence method
Inhibition of recombinant rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by colorimetry
Assay data:7 Active, 3 Activity ≤ 1 µM, 8 Tested
Inhibition of Schistosoma mansoni TGR
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Reversible inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins in presence of NADPH followed by substrate addition and measured for 20 mins by Ellman's method
Assay data:6 Active, 6 Tested
Inhibition of rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
Assay data:6 Active, 2 Activity ≤ 1 µM, 14 Tested
Inhibition of NADPH-reduced rat TrxR1 U498C mutant assessed as suppression of DTNB reduction at 1 to 5 uM incubated for 1 hr
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Irreversible inhibition of NADPH-reduced rat TrxR1 assessed as suppression of DTNB reduction incubated for 1 hr followed by compound removal from incubation mixture by column desalting
Inhibition of NADPH-reduced rat TrxR1 assessed as suppression of DTNB reduction incubated for 1 hr
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assay
Assay data:9 Active, 21 Tested
Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assay
Assay data:6 Active, 21 Tested
Inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of DTNB reduction at 5 uM incubated for 1 hr in presence of DTNB measured every 5 mins for 1 hr
Inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of DTNB reduction at 5 uM pretreated for 1 hr followed by DTNB addition measured every 5 mins for 1 hr
Induction of recombinant rat TrxR1 NADPH oxidase activity expressed in Escherichia coli harboring gor mutant assessed as superoxide generation by measuring cytochrome C reduction at 62.5 uM measured in presence of SOD
Induction of recombinant rat TrxR1 NADPH oxidase activity expressed in Escherichia coli harboring gor mutant assessed as increase in NADPH consumption at 62.5 uM measured after 30 mins relative to control
Inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of insulin reduction at 20 uM using Trx as substrate pretreated for 30 mins followed by Trx addition for 30 mins and subsequent eosin-labelled bovine insulin addition measured every 5 mins for 1 hr by fluorescence assay
Inhibition of oxidized recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of DTNB reduction at 2 uM pretreated for 30 mins followed by NADPH addition for 30 mins and subsequent DTNB addition measured every 5 mins for 1 hr
Irreversible inhibition of NADPH-reduced recombinant rat TrxR1 expressed in Escherichia coli harboring gor mutant assessed as suppression of DTNB reduction at 2 uM pretreated for 1 hr followed by NADPH addition for 30 mins and subsequent DTNB addition measured every 5 mins for 1 hr
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