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Modulation of human TRPV1 transfected in HEK293 cells
Assay data:3 Tested
SummaryRelated BioAssays by Target
Antagonist activity at human recombinant TRPV1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced TRPV1 channel activation by FLIPR-based Ca2+ assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at human TRPV1 expressed in HEK293F cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR-based Ca2+ assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant TRPV1
Assay data:1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human recombinant TPRV1
Agonist activity at human TRPV1 overexpressed in HEK293 cells incubated for 1 hr by Fluo-4 AM dye based microscopic analysis
Activation of human TRPV1 expressed in HEK293F cells
Inhibition of human TRPV1
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to human TRPV1 assessed as inhibition constant by SPR analysis
Antagonist activity at TRPV1 (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of TRPV1 (unknown origin)
Antagonist activity at TRPV1 (unknown origin) expressed in HEK293T cells assessed as inhibition of agonist induced channel current by whole-cell patch clamp recordings
Assay data:1 Tested
Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by measuring efficacy by Fluo4-AM based assay relative to ionomycin
Assay data:29 Tested
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as desensitization by measuring inhibition of capsaicin-induced intracellular calcium accumulation preincubated for 5 mins followed by capsaicin stimulation by Fluo4-AM based assay
Assay data:21 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 29 Tested
Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assay
Assay data:23 Active, 17 Activity ≤ 1 µM, 29 Tested
Desensitization of TRPV1 in C57BL/Nrj mouse dorsal root ganglion primary sensory neurons assessed as reduction in capsaicin-stimulated calcium influx at 0.5 uM preincubated for 2 mins followed by capsaicin stimulation and measured after 20 secs
Assay data:1 Active, 1 Tested
Desensitization of TRPV1 in naive C57BL/Nrj mouse dorsal root ganglion primary sensory neurons assessed as reduction in capsaicin-stimulated calcium influx at 1 uM preincubated for 2 mins followed by capsaicin stimulation and measured after 20 secs relative to control
Assay data:2 Tested
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of protons activation at 3 uM at pH 6 by fluorometric imaging plate reader analysis relative to control
Assay data:34 Tested
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin induced intracellular Ca2+ ions by fluorometric imaging plate reader analysis
Assay data:35 Active, 3 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
Binding affinity to human TRPV1 assessed as dissociation constant by SPR analysis
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