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Displacement of [3H]-epibatidine from Lymnaea stagnalis Acetylcholine-binding protein measured after 1 hr by liquid scintillation counter
Assay data:3 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]-epibatidine from recombinant Lymnaea stagnalis Acetylcholine-binding protein assessed as inhibition of [3H]-epibatidine binding by radioligand saturation binding assay
Assay data:2 Active, 2 Tested
Displacement of [3H]-epibatidine from recombinant Lymnaea stagnalis Acetylcholine-binding protein assessed as inhibition of [3H]-epibatidine binding at 20 uM by radioligand saturation binding assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]-epibatidine from recombinant Lymnaea stagnalis Acetylcholine-binding protein assessed as inhibition of [3H]-epibatidine binding at 40 uM by radioligand saturation binding assay
Displacement of [3H]-epibatidine from recombinant Lymnaea stagnalis Acetylcholine-binding protein assessed as fold change in inhibition of [3H]-epibatidine binding by radioligand binding assay relative to CTD(21-50)
Displacement of [3H]-epibatidine from recombinant Lymnaea stagnalis Acetylcholine-binding protein by radioligand binding assay
Assay data:1 Active, 4 Tested
Interaction Assay from Article 10.1021/bi1006354: "Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein."
Assay data:8 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Radioligand Competition Assay from Article 10.1074/jbc.M111.292243: "Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed."
Assay data:8 Active, 7 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates. from Article 10.1124/mol.112.080291: "Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates."
Assay data:41 Active, 34 Activity ≤ 1 µM, 43 Tested
Displacement of [125I]bungarotoxin from Lymnaea stagnalis nicotinic acetylcholine receptor assessed as residual radioligand binding relative to control
Assay data:5 Tested
SummaryRelated BioAssays by Target
Binding affinity to Lymnaea stagnalis nicotinic acetylcholine receptor by fluorescence based assay
Assay data:8 Active, 11 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein at 100 nM incubated for 60 mins followed by 3 hrs incubation in dark condition by microbeta counting analysis relative to control
Assay data:4 Tested
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condition by microbeta counting analysis
Assay data:25 Active, 1 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
Binding affinity to Lymnaea stagnalis AChBP after 300 seconds by SPR biosensor analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]epibatadine from Lymnaea stagnalis recombinant C-terminal His-tagged AChBP expressed in baculovirus infected SF9 cells after 1.5 hrs by scintillation counting analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding affinity to freshwater snail Lymnaea stagnalis AChBP assessed as [3H]EPI binding by radioligand binding assay
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP
Assay data:5 Active, 2 Activity ≤ 1 µM, 6 Tested
Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs by scintillation counting analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 10 Tested
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