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Activation of PKM2 (unknown origin) in presence of sorafenib
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of PKM2 (unknown origin) in presence of HSP90 inhibitor
Activation of PKM2 in human NCI-H1299 cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Activation of PKM2 (unknown origin)
Assay data:15 Active, 12 Activity ≤ 1 µM, 17 Tested
Binding affinity to PKM2 (unknown origin) assessed as Gibbs free energy
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to PKL (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to PKM2 (unknown origin)
Assay data:1 Tested
Binding affinity to PKM1 (unknown origin)
Inhibition of PKL (unknown origin)
Inhibition of PKM1 (unknown origin)
Inhibition of PKM2 (unknown origin) at 10 uM relative to control
Assay data:3 Tested
Inhibition of PKM1 (unknown origin) at 10 uM relative to control
Inhibition of PKM2 (unknown origin)
Assay data:12 Active, 5 Activity ≤ 1 µM, 23 Tested
Inhibition of PKM2 (unknown origin) Ser362, Lys367, Lys207, Ser77, Asp177, Asp178, Asn75, Gly52, Gly128 residues
Binding affinity to PKM2 (unknown origin) assessed as Michaelis-constant
Inhibition of recombinant PKM2 (unknown origin) Asp178, Asp177, Ser362, Lys367, Hie78, Ser205, Gly128, Thr129, Tyr83, Asn75, Ile51 residues at 40 uM relative to control
Inhibition of recombinant PKM2 (unknown origin) Asp177, Asp178, Asn75, Ile51, Gly128, Hie78, Lys367 residues
Inhibition of recombinant PKM2 (unknown origin) Ile335, Lys367, Lys207, Thr129, Lys206, Lys207, Asn75, Hie78 residues
Inhibition of recombinant PKM2 (unknown origin) Gly128, Lys207, Hie78, Asn75, Ile51, Lys367, Gly79 residues
Inhibition of recombinant PKM2 (unknown origin) Thr129, Ser205, Hie78, Lys367, Ala366, Gly52 residues
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