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Selectivity interaction (CEREP ligand displacement assays (non-kinase proteins)) EUB0001326b CHRM1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b CHRM1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001079a CHRM1
Selectivity interaction (Panel of non-epigenetic targets (kinases, GPCRs, ion channels, and transporters, Eurofins) ) EUB0000271b CHRM1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001072a CHRM1
Selectivity interaction (Panel of kinases, GPCRs, ion channels and transporters (enzymatic assay)) EUB0000223bCl CHRM1
Selectivity interaction (Panel of kinases, GPCRs, ion channels and transporters (enzymatic assay)) EUB0000266bCl CHRM1
Selectivity interaction (Safety Panel 44tm (Eurofins)) EUB0000162b CHRM1
Selectivity interaction (Eurofins Cerep-Panlabs Safety Screen 44 (GPCRS, Transporters, Ion Channels, Nuclear Receptors, other enzymes)) EUB0000878a CHRM1
Selectivity interaction (Muscarinic M1 receptor assay, human recombinant ) EUB0000877a CHRM1
Selectivity interaction (BET inhibitor selectivity panel (Human antagonist intracellular Ca2+ fluorescence assay)) EUB0000102c CHRM1
Inhibition of Muscarinic M1 at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against MUSCARIN/NS in the Eurofins Panlabs screen (BI) by Radioactive Assay
Activity against M1/R in the Eurofins Panlabs screen (BI) by Radioactive Assay
Activity against M1/H in the Eurofins SafetyScreen44 (CEREP) (BI) by Radioactive Assay (Cerep_91)
Assay data:5 Tested
SafetyScreen: M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay, catalogue number: 91
Assay data:10 Tested
PDSP Primary Binding target: CHRM1 - Compounds are tested at 10 uM concentration, plate are incubated at room temperature in the dark for 90 minutes. Reaction are stopped by vacuum filtration onto 0.3% polyethyleneimine soaked filter mats using Filtermate harvester. Scintilation cocktail is then melted onto microwave-dried filters on a hot plate and the radio activity is counted in Microbia counter.
Assay data:16 Active, 175 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
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