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Determination of the Inhibitory Activity of the Compounds of the Present Invention on PARP1 Enzyme from US Patent US20240228490: "HETEROCYCLIC DERIVATIVE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:36 Active, 14 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzymatic Biochemical Assay of PARP from US Patent US20240158406: "PIPERAZINE DERIVATIVE AND USE THEREOF IN MEDICINE"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
assay on hold
Summary
Inhibition of PARP1 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PARP1 (unknown origin) assessed as inhibition constant
Inhibition of PARP1 (unknown origin) with prodrug pretreated for 24 hrs in human liver lysosome lysate using biotinylated NAD+ and activated DNA template as substrate at 0.5 uM by colorimetric assay relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PARP1 (unknown origin) with prodrug pretreated for 2 hrs in human liver lysosome lysate using biotinylated NAD+ and activated DNA template as substrate at 0.5 uM by colorimetric assay relative to control
Inhibition of PARP1 (unknown origin) with prodrug pretreated for 30 mins in human liver lysosome lysate using biotinylated NAD+ and activated DNA template as substrate at 0.5 uM by colorimetric assay relative to control
Inhibition of PARP1 (unknown origin) using biotinylated NAD+ and activated DNA template as substrate at 0.5 uM by colorimetric assay relative to control
Inhibition of mouse recombinant PARP-1 incubated for 60 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human PARP-1 incubated for 18 to 20 hrs by scintillation proximity assay
Inhibition of calf thymus PARP-1
Inhibition of human PARP-1 using histone as substrate incubated for 16 hrs by ELISA assay
Inhibition of human recombinant PARP-1 (662 to 1011 residues)
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PARP-1 (unknown origin) assessed as inhibition constant
Inhibition of PARP-1 (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of human full-length recombinant PARP-1
Inhibition of human PARP-1
Assay data:1 Tested
Inhibition of human recombinant PARP-1
Inhibition of PARP1 (unknown origin) incubated for 1 hrs by colorimetric analysis
Assay data:4 Active, 11 Tested
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