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FP (VHL:VZ185:BRD9-BD) (Fluorescence polarization: ternary complex (VHL:VZ185:BRD9-BD))
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
FP (VHL:VZ185) (Fluorescence polarization: binary complex (VHL:VZ185))
ITC (VHL:VZ185:BRD9-BD) (ITC: ternary complex (VHL:VZ185:BRD9-BD))
ITC (VHL:VZ185) (ITC binary complex (VHL:VZ185))
Protac activity at VHL E3 ligase/BRD4 in HEK293 cells assessed as BRD4 degradation in presence of linker 3 by HiBiT assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at VHL E3 ligase/BRD4 in HEK293 cells assessed as degradation maximum by HiBiT assay relative to control
Assay data:11 Tested
Protac activity at VHL E3 ligase/BRD4 in HEK293 cells assessed as BRD4 degradation by HiBiT assay
Assay data:2 Active, 12 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at VHL E3 ligase/BRD4 in HEK293 cells assessed as BRD4 degradation by HiBiT assay relative to control
Protac activity at VHL E3 ligase/BRD4 in HEK293 cells assessed as BRD4 degradation in presence of linkers 14 and 15 by HiBiT assay
Assay data:1 Active, 2 Tested
PROTAC activity at VHL/ER-alpha in human VHL knockdown MCF7 cells assessed as ERalpha degradation level at 10 uM incubated for 6 hrs by Western blot analysis
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation level at 10 uM pretreated with VHL-L followed by compound addition and measured after 6 hrs by Western blot analysis
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation level at 10 uM pretreated with tamoxifen followed by compound addition and measured after 6 hrs by Western blot analysis
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation at 10 uM preincubated for 1 hr with MG132 followed by compound addition and measured after 6 hrs by Western blot analysis
PROTAC activity at VHL/3 Flag-tagged ER-alpha in human NCI-H1299 cells assessed as ERalpha degradation incubated for 6 hrs by Western blot analysis
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation level at 10 uM incubated 3 to 6 hrs in the presence of NEM by Western blot analysis
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation level at 10 uM by Western blot analysis
PROTAC activity at VHL/ER-alpha in human BT-474 cells assessed as ERalpha degradation by Western blot analysis
PROTAC activity at VHL/3 Flag-tagged ER-alpha in HBE cells assessed as ERalpha degradation at 0.5 to 10 uM incubated for 6 hr by western blot analysis
Assay data:1 Active, 1 Tested
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation at 10 uM incubated for 6 hrs by Western blot analysis
PROTAC activity at VHL/ER-alpha in human MCF7 cells assessed as ERalpha degradation at 10 uM incubated for 4 hrs by Western blot analysis
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