Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Modulation of human TRPV1 transfected in HEK293 cells
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human recombinant TRPV1 expressed in HEK293T cells assessed as inhibition of capsaicin-induced TRPV1 channel activation by FLIPR-based Ca2+ assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human TRPV1 expressed in HEK293F cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ level by FLIPR-based Ca2+ assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant TRPV1
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human recombinant TPRV1
Agonist activity at human TRPV1 overexpressed in HEK293 cells incubated for 1 hr by Fluo-4 AM dye based microscopic analysis
Activation of human TRPV1 expressed in HEK293F cells
Inhibition of human TRPV1
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to human TRPV1 assessed as inhibition constant by SPR analysis
Antagonist activity at TRPV1 (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of TRPV1 (unknown origin)
Antagonist activity at TRPV1 (unknown origin) expressed in HEK293T cells assessed as inhibition of agonist induced channel current by whole-cell patch clamp recordings
Assay data:1 Tested
Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by measuring efficacy by Fluo4-AM based assay relative to ionomycin
Assay data:29 Tested
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as desensitization by measuring inhibition of capsaicin-induced intracellular calcium accumulation preincubated for 5 mins followed by capsaicin stimulation by Fluo4-AM based assay
Assay data:21 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 29 Tested
Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assay
Assay data:23 Active, 17 Activity ≤ 1 µM, 29 Tested
Desensitization of TRPV1 in C57BL/Nrj mouse dorsal root ganglion primary sensory neurons assessed as reduction in capsaicin-stimulated calcium influx at 0.5 uM preincubated for 2 mins followed by capsaicin stimulation and measured after 20 secs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Desensitization of TRPV1 in naive C57BL/Nrj mouse dorsal root ganglion primary sensory neurons assessed as reduction in capsaicin-stimulated calcium influx at 1 uM preincubated for 2 mins followed by capsaicin stimulation and measured after 20 secs relative to control
Assay data:2 Tested
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of protons activation at 3 uM at pH 6 by fluorometric imaging plate reader analysis relative to control
Assay data:34 Tested
Antagonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin induced intracellular Ca2+ ions by fluorometric imaging plate reader analysis
Assay data:35 Active, 3 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
Binding affinity to human TRPV1 assessed as dissociation constant by SPR analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on