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Electrophysiology from US Patent US20240294543: "CYCLOHEPTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM"
Assay data:68 Active, 68 Activity ≤ 1 µM, 68 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay for γ2-Containing GABAA Subtypes from US Patent US20240294543: "CYCLOHEPTA-THIENO-DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM"
Assay data:68 Active, 3 Activity ≤ 1 nM, 68 Activity ≤ 1 µM, 68 Tested
Radioligand Binding Assay from US Patent US20240287082: "NEW BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM"
Assay data:29 Active, 4 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
RadioligandBinding Assay from US Patent US20240270744: "NEW PYRIDO DIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM"
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001492b GABRA1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Eurofins-Panlabs Screen) EUB0001548a GABRA1
Selectivity interaction (Eurofins CEREP Diversity Profile (receptors and ion channels)) EUB0000279b GABRA1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001079a GABRA1
Selectivity interaction (Panel of non-epigenetic targets (kinases, GPCRs, ion channels, and transporters, Eurofins) ) EUB0000271b GABRA1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0001072a GABRA1
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000276b GABRA1
Inhibition of GABAA, Flunitrazepam, Central at 10.0 M in the Eurofins Panlabs Safety Screen
Inhibition of GABAA, Chloride Channel, TBOB at 10.0 M in the Eurofins Panlabs Safety Screen
Activity against GABAACL+ in the Eurofins Panlabs screen (BI) by Radioactive Assay
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