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Activation of ERbeta in human HepG2 cells at 10 uM incubated for 24 hrs by luciferase reporter assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of ERbeta degradation in human MCF7 cells assessed as by Western blotting analysis
Binding affinity to ERbeta (unknown origin) by LanthaScreen TR-FRET competitive binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of ERbeta degradation in human MCF7 cells
Induction of ERbeta degradation in human ACHN cells
Induction of ERbeta degradation in human HEK293T cells
Inhibition of ERbeta (unknown origin) incubated for 4 hrs by fluorescence polarization assay
Binding affinity to human ERbeta assessed as relative binding affinity incubated under vibration for 1 min followed by 2 hrs incubation under dark condition by fluorescence polarization assay relative to estradiol
Assay data:52 Tested
Agonist activity at Gal4DBD-fused ER-beta LBD (unknown origin) transfected in luc2p-Gal4-HEK293 cells assessed as receptor transactivation at 50 uM incubated for 24 hrs by Bright-Glo luciferase reporter gene assay
Antagonist activity at wild type human ERbeta in HEK-293T cells transfected with 3xERE-driven luciferase reporter plasmid by luciferase reporter gene assay
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Partial agonist activity at wild type human ERbeta in HEK-293T cells transfected with 3xERE-driven luciferase reporter plasmid by luciferase reporter gene assay
Assay data:3 Tested
Inhibition of ERbeta (261 to 500 residues) in doxycycline-induced human HEK293 cells incubated overnight by luciferase based assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
PROTAC activity at VHL/ERbeta in human NCI-H1975 cells assessed as induction of ERbeta degradation at 1 to 10 uM incubated for 12 hrs by Western blot analysis
Assay data:2 Tested
Induction of ERbeta degradation in human NCI-H1975 cells at 1 to 10 uM incubated for 12 hrs by Western blot analysis
Induction of ERbeta degradation in human NCI-H1975 cells at 10 uM incubated for 12 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Binding affinity to ERbeta (unknown origin) assessed as dissociation constant
Binding affinity to ERbeta (unknown origin) assessed as inhibition constant incubated for 2 hrs by fluorescence polarization assay
Assay data:17 Active, 2 Activity ≤ 1 µM, 26 Tested
Binding affinity to ERbeta (unknown origin) assessed as relative binding affinity incubated for 2 hrs by fluorescence polarization assay relative to estradiol
Assay data:26 Tested
Activation of Gal-DBD and NHRLBD fused ERbeta (unknown origin) transfected in African green monkey CV-1 cells by luciferase reporter assay
Antagonist activity at ERbeta (unknown origin)
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