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Inhibition of TrxR in human NCI-H460 cells measured after 6 hrs by DTNB reduction assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TrxR in human NCI-H460 cells at 2 uM measured after 6 hrs by DTNB reduction assay relative to control
Inhibition of TrxR in human MRC5 cells at 2 uM measured after 6 hrs by fluorescence microscopy based analysis
Inhibition of TrxR in human NCI-H460 cells at 2 uM measured after 6 hrs by fluorescence microscopy based analysis
Assay data:2 Tested
Inhibition of TrxR in human NCI-H460 cells measured after 6 hrs by fluorescence microscopy based analysis
Inhibition of recombinant rat TrxR1 incubated for 1 hr in presence of NADPH by microplate reader analysis
Assay data:6 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TrxR3 (unknown origin) incubated for 1 hr in presence of NADPH by microplate reader analysis
Inhibition of TrxR1 in human HCT-116 cells incubated for 24 hrs
Assay data:1 Active, 2 Tested
Inhibition of TrxR1 in human HeLa cells incubated for 24 hrs
Binding affinity to TXRD1 in human NCI-H522 cells at 10 uM incubated for 1 hr by Biotin-TAMRA pull down based mass spectrometry
Assay data:1 Active, 1 Tested
Binding affinity to TXRD1 in human NCI-H522 cells at 10 uM incubated for 1 hr by Biotin-TAMRA pull down based western blot analysis
Inhibition of Recombinant TrxR1 and GR from US Patent US11208384: "Sulfinylpyridines and their use in the treatment of cancer"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US11168069: "Heterocyclylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of Recombinant TrxR1 from US Patent US11161815: "Hydrocarbylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:33 Active, 32 Activity ≤ 1 µM, 33 Tested
Inhibition Assay from US Patent US11028067: "Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer"
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
In vitro Assay from US Patent US9018255: "Esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them, and their use as inhibitors of the thioredoxin—thioredoxin reductase system"
Assay data:6 Active, 7 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to rat TrxR1 assessed as adduct formation at 7.2 uM by LC-MS/MS analysis
Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 30 mins by DTNB assay
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Inhibition of Schistosoma mansoni thioredoxin glutathione reductase incubated for 50 mins by thio-glo reagent based fluorescence method
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