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Inhibition of MRP2 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of sulfasalazine-stimulated MRP2 ATPase activity (unknown origin) in presence of GSH
Assay data:2 Tested
Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 10 uM after 72 hrs in presence of cisplatin by MTT assay (Rvb = 4902.89 +/- 130.33 nM)
Assay data:3 Tested
Reversal of MRP2-mediated multidrug resistance in human KBV cells assessed as cisplatin IC50 at 5 uM after 72 hrs in presence of cisplatin by MTT assay (Rvb = 4902.89 +/- 130.33 nM)
Inhibition of MRP2 (unknown origin) at upto 3 uM
Inhibition of MRP2 (unknown origin) at 1 to 10 uM
Inhibition of Sprague-Dawley rat Mrp2 expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in CDF uptake by fluorescence assay
Substrate activity at human MRP2 expressed in Sf9 membrane vesicles assessed as protein-mediated drug uptake in presence of MRP2 inhibitor-benzbromarone by LC-MS/MS analysis
Substrate activity at human MRP2 expressed in Sf9 membrane vesicles assessed as Km
Substrate activity at human MRP2 expressed in Sf9 membrane vesicles assessed as Vmax per mg protein
Ratio of compound effect for substrate activity at human MRP2 expressed in Sf9 membrane vesicles assessed as protein-mediated drug uptake in presence of ATP to compound effect for substrate activity at human MRP2 expressed in Sf9 membrane vesicles assessed as protein-mediated drug uptake in absence of ATP
Substrate activity at human MRP2 expressed in Sf9 membrane vesicles assessed as protein-mediated drug uptake by LC-MS/MS analysis
Stimulation of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay
Assay data:39 Active, 39 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay
Assay data:9 Active, 598 Tested
Inhibition of human MRP2
Assay data:1 Active, 2 Tested
Inhibition of MRP2 in human Caco2 cells assessed as reduction in pravastatin sodium efflux at 4 uM relative to control
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