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Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate and SAM measured after 15 mins by chromatographic analysis
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human MB-COMT expressed in HEK293 cells using dopamine as substrate and SAM as cofactor preincubated for 30 mins followed by substrate addition and measured after 40 mins by HTRF assay
Assay data:24 Active, 1 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 27 Tested
Inhibition of c-terminal hexa-His tagged human MB-COMT (unknown origin)
Assay data:5 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 5 Tested
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation
Assay data:57 Activity ≤ 1 nM, 344 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation
Assay data:59 Activity ≤ 1 nM, 281 Activity ≤ 1 µM, 2023 Tested
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